Gastrointestinal fractional absorption of radionuclides in adult domestic ruminants

Howard, B.J.; Beresford, N.A.; Barnett, C.L.; Fesenko, S.

doi:10.1016/j.jenvrad.2009.03.023

Cited by 15 publications

(14 citation statements)

References 51 publications

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“…The chemical form and extent of binding to soil adhered to ingested material will impact on fractional absorption by ruminants and vary between elements16. Nevertheless, there is a good correlation between the fractional absorption values for each element and the transfer parameter values for both milk products.…”

Section: Discussionmentioning

confidence: 99%

“…The fractional absorption dataset16 included values from (i) literature studies, (ii) a then recent review of Russian-language information on ruminant absorption43 and (iii) an agricultural review by the National Research Council26. The latter source was used for the fractional absorption values of Ca, Cl, Fe, Mn, Na, P, Se and Zn.…”

Section: Methodsmentioning

confidence: 99%

“…The latter source was used for the fractional absorption values of Ca, Cl, Fe, Mn, Na, P, Se and Zn. The ruminant fractional absorption values (F a ) used for this study were reported in TRS 47212 and a review paper for ruminants16 (Table 1). For most elements there were fewer than 10 data values in the dataset.…”

Section: Methodsmentioning

confidence: 99%

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How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

Howard

Wells

Barnett

et al. 2016

Sci Rep

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The quality and quantity of data used to derive transfer parameter values for milk are variable and there are many data gaps for elements/radionuclides which may need to be considered for risk assessment of the agricultural foodchain. There has been a recent focus on critically evaluating current methods to fill data gaps and on identifying extrapolation methods to derive suitable values for the elements, and particularly radioisotopes, with no or sparse data. The relationship between fractional absorption of elements in the ruminant gastrointestinal tract and transfer to milk has been explored to determine whether knowledge of the former can be used to predict the latter. A relationship has been derived between fractional absorption of elements and two empirical ratios commonly used to quantify transfer to milk; transfer coefficients (element concentration in milk divided by element daily intake) and concentrations ratios (concentration in milk divided by concentration in feed). We propose that fractional absorption may be used to predict the order of magnitude of the transfer to milk of elements/radionuclides for which no relevant data have yet been identified or collated.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

Howard

Wells

Barnett

et al. 2016

Sci Rep

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“…The authors provide details on the approach used to estimate radionuclide cycling allowing them to provide prospective estimates as to when the maximum in cycling is expected and from which soil layer uptake is likely to occur. Howard and Beresford (2009) describe the derivation of recommended values for the gastrointestinal absorption of radionuclides in adult ruminants. Although Data on Sr, Cs and I comprise more than 50% of the total entries the paper provides values for 23 other radionuclides.…”

Section: Synopsismentioning

confidence: 99%

The international conference on radioecology and environmental radioactivity

Strand

Brown

2009

Journal of Environmental Radioactivity

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“…Radiocesium ( 137 Cs) and its chemical analog radiothallium ( 201 Tl) mimic physiological functioning of potassium ion and therefore can get readily absorbed and easily incorporated into all living cells, particularly in muscle and cardiac cells. 9,10…”

Section: Introductionmentioning

confidence: 99%

Decorporation potential of lansoprazole against radiothallium (²⁰¹Tl) in internally contaminated BALB/c mice and New Zealand White rabbits

et al. 2018

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Introduction: This study examined the decorporation potential of lansoprazole (LNP) as radioactivity decorporation agent for radiothallium (201Tl) in internally contaminated BALB/c mice and New Zealand White rabbits using radiometry and gamma scintigraphy. Methods: Animals were divided into three groups, that is, control, pretreatment-1 (1X LNP), and pretreatment-2 (2X LNP). Mice received LNP intraperitoneally, while in rabbits LNP was given through oral route 0.5 and 1.5 h before radiothallium administration, respectively. Mice and rabbits used in the experiment were administered 1.48 and 11.1 MBq radiothallium (201TlCl) through intravenous and oral route, respectively. Once started as prophylactic, LNP was continued as therapeutic twice a day till the end of study period. Radiometry and gamma scintigraphy were used to monitor radiothallium retention and uptake patterns in animals. Gamma scintigraphic images of rabbits were taken at different time intervals up to 72 h and were analyzed for comparative uptake pattern of 201TlCl in all the groups. Results: LNP treatment significantly increased the 201Tl elimination over untreated control and considerably reduced the retention of 201Tl in various tissues and organs. Decrease in radiothallium uptake up to 40% was observed in LNP-treated mice as compared to untreated control. While in rabbits, whole-body radioactivity burden at 72 h was found to be 31.24%, 26%, and 18.54% in untreated control, 9 and 18 mg/kg LNP-treated groups, respectively. Conclusion: LNP exhibited dose-dependent decorporation potential to effectively enhance the elimination of 201Tl in mice and rabbits experimentally contaminated with 201TlCl.

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Gastrointestinal fractional absorption of radionuclides in adult domestic ruminants

Cited by 15 publications

References 51 publications

How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

The international conference on radioecology and environmental radioactivity

Decorporation potential of lansoprazole against radiothallium (²⁰¹Tl) in internally contaminated BALB/c mice and New Zealand White rabbits

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Gastrointestinal fractional absorption of radionuclides in adult domestic ruminants

Cited by 15 publications

References 51 publications

How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

The international conference on radioecology and environmental radioactivity

Decorporation potential of lansoprazole against radiothallium (201Tl) in internally contaminated BALB/c mice and New Zealand White rabbits

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Product

Resources

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Decorporation potential of lansoprazole against radiothallium (²⁰¹Tl) in internally contaminated BALB/c mice and New Zealand White rabbits