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“…Most of the patients' bodies have antibodies against GQ1b (a ganglioside component of the nerve) [57] . A ganglioside is a molecule with ceramide attached to a group of hexose-type sugars and contains several N-acetylneuraminic acid groups [58] . The production of anti-ganglioside antibodies after the infection or post-vaccination mostly results from molecular mimicry, where the immune system produces antibodies against the microbial antigen.…”
Section: Pathophysiology Of Guillain Barré Syndromementioning
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“…Most of the patients' bodies have antibodies against GQ1b (a ganglioside component of the nerve) [57] . A ganglioside is a molecule with ceramide attached to a group of hexose-type sugars and contains several N-acetylneuraminic acid groups [58] . The production of anti-ganglioside antibodies after the infection or post-vaccination mostly results from molecular mimicry, where the immune system produces antibodies against the microbial antigen.…”
Section: Pathophysiology Of Guillain Barré Syndromementioning
“…Other peripheral nerve diseases in older individuals that potentially produces autonomic dysfunction are listed below. [56][57][58] Sjogren syndrome is an autoimmune neuropathy that affects dorsal root ganglia and small-diameter fibers, presenting with sensory ataxia as well as autonomic dysfunction (orthostatic hypotension, urinary retention, and constipation). 59,60 Amyloidosis is a disease in which amyloid deposits are systemically found; including acquired immunoglobulin light chain (AL, sometimes associated with myeloma) amyloidosis and hereditary transthyretin (TTR, prealbumin) amyloidosis.…”
Section: Other Peripheral Nerve Diseases In Older Individualsmentioning
“…Other peripheral nerve diseases in older individuals that potentially produces autonomic dysfunction are listed below 56–58 …”
Section: Brain and Peripheral Nerve Diseases In Older Individualsmentioning
“…La afectación tanto del ganglio autonómico 74 como del ganglio sensitivo 75 puede ser de origen paraneoplásico y hay que estar atento a este posible diagnóstico por las implicaciones pronósticas y terapéuticas que tiene. Una de las principales características de estos cuadros es la afectación del tracto gastrointestinal 76 . En estos pacientes, además de los estudios dirigidos al diagnóstico de la NFF o la ganglionopatía, habrá que solicitar anticuerpos onconeuronales, así como marcadores para detectar posibles tumores primarios.…”
Section: Neuropatías Autonómicas Autoinmunesunclassified