Gastrointestinal dysfunction in neuroinflammatory diseases: Multiple sclerosis, neuromyelitis optica, acute autonomic ganglionopathy and related conditions

Sakakibara, Ryuji

doi:10.1016/j.autneu.2021.102795

Cited by 5 publications

(9 citation statements)

References 165 publications

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“…Other peripheral nerve diseases in older individuals that potentially produces autonomic dysfunction are listed below. [56][57][58] Sjogren syndrome is an autoimmune neuropathy that affects dorsal root ganglia and small-diameter fibers, presenting with sensory ataxia as well as autonomic dysfunction (orthostatic hypotension, urinary retention, and constipation). 59,60 Amyloidosis is a disease in which amyloid deposits are systemically found; including acquired immunoglobulin light chain (AL, sometimes associated with myeloma) amyloidosis and hereditary transthyretin (TTR, prealbumin) amyloidosis.…”

Section: Other Peripheral Nerve Diseases In Older Individualsmentioning

confidence: 99%

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Autonomic dysfunction in older individuals: The contributions of multiple brain diseases and diabetes

Sakakibara

Sawai

Ogata

et al. 2022

Neurology & Clinical Neurosc

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The populations of older individuals (age >60 years old) continue to increase worldwide from 400 million in 1980 to 1050 million in 2020, 1 necessitating increases in medical care, particularly for the disorders that develop with age. 2 Geriatric syndrome (symptoms that are commonly seen in older individuals) includes dementia/delirium, 3 gait difficulty/fall 4 /aspiration, 5 and autonomic dysfunction. 1 Among the geriatric syndrome, the brain is contributing to dementia and gait difficulty. 3 Autonomic dysfunctions such as orthostatic hypotension, 2 overactive bladder, and constipation also increase with age. However, autonomic dysfunction in older populations has not been fully delineated, and it is suspected that neurologic etiologies might underlie this condition. 3 This review briefly summarizes (i) the brain and peripheral nerve diseases that are common in older populations; (ii) the mechanisms and management/care of autonomic dysfunction.

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Section: Other Peripheral Nerve Diseases In Older Individualsmentioning

confidence: 99%

“…Other peripheral nerve diseases in older individuals that potentially produces autonomic dysfunction are listed below 56–58 …”

Section: Brain and Peripheral Nerve Diseases In Older Individualsmentioning

confidence: 99%

Autonomic dysfunction in older individuals: The contributions of multiple brain diseases and diabetes

Sakakibara

Sawai

Ogata

et al. 2022

Neurology & Clinical Neurosc

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“…La afectación tanto del ganglio autonómico 74 como del ganglio sensitivo 75 puede ser de origen paraneoplásico y hay que estar atento a este posible diagnóstico por las implicaciones pronósticas y terapéuticas que tiene. Una de las principales características de estos cuadros es la afectación del tracto gastrointestinal 76 . En estos pacientes, además de los estudios dirigidos al diagnóstico de la NFF o la ganglionopatía, habrá que solicitar anticuerpos onconeuronales, así como marcadores para detectar posibles tumores primarios.…”

Section: Neuropatías Autonómicas Autoinmunesunclassified

Estudio y manejo de las neuropatías de fibra fina

Esteban¹,

Merino²,

Teijeira-Portas³

et al. 2024

KRANION

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“…Most of the patients' bodies have antibodies against GQ1b (a ganglioside component of the nerve) [57] . A ganglioside is a molecule with ceramide attached to a group of hexose-type sugars and contains several N-acetylneuraminic acid groups [58] . The production of anti-ganglioside antibodies after the infection or post-vaccination mostly results from molecular mimicry, where the immune system produces antibodies against the microbial antigen.…”

Section: Pathophysiology Of Guillain Barré Syndromementioning

confidence: 99%

Guillain-Barre syndrome: An autoimmune disorder post-COVID-19 vaccination?

Khan

Ahmad

Ualiyeva

et al. 2022

Clinical Immunology Communications

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SARS-CoV-2 causes Coronavirus Disease 2019 (COVID-19), an infectious condition that can present none or one or more of these symptoms: fever, cough, headache, sore throat, loss of taste and smell, aches, fatigue and musculoskeletal pain. For the prevention of COVID-19, there are vaccines available including those developed by Pfizer, Moderna, Sinovac, Janssen, and AstraZeneca. Recent evidence has shown that some COVID-19-vaccinated individuals can occasionally develop as a potential side effect Guillain-Barre syndrome (GBS), a severe neurological autoimmune condition in which the immune response against the peripheral nerve system (PNS) can result in significant morbidity. GBS had been linked previously to several viral or bacterial infections, and the finding of GBS after vaccination with certain COVID-19, while rare, should alert medical practitioners for an early diagnosis and targeted treatment. Here we review five cases of GBS that developed in different countries after COVID-19 vaccination.

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Gastrointestinal dysfunction in neuroinflammatory diseases: Multiple sclerosis, neuromyelitis optica, acute autonomic ganglionopathy and related conditions

Cited by 5 publications

References 165 publications

Autonomic dysfunction in older individuals: The contributions of multiple brain diseases and diabetes

Autonomic dysfunction in older individuals: The contributions of multiple brain diseases and diabetes

Estudio y manejo de las neuropatías de fibra fina

Guillain-Barre syndrome: An autoimmune disorder post-COVID-19 vaccination?

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