Gastrointestinal Dysbiosis Accompanied of Helicobacter Pylori Infection and its Correction by Probiotic

Ermolenko, E. I.; Varsin, S; Барышникова, Н. В.; Сварваль, А В; Ферман, Р С; Беседина, Н. К.; Zakrevskaya, A. V.; Молостова, А С; Суворов, Александр Николаевич

doi:10.23937/2469-584x/1510055

Cited by 4 publications

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“…The Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria showed a decreased abundance, while Spirochetes and Acidobacteria showed an increased abundance [29]. The eradication of H. pylori can significantly increase the abundance of the gastric and downstream intestinal flora [30], such as Clostridium, Bacillus, etc., while the abundance of fungi such as yeast was significantly increased [31]. Disorders of the intestinal microbiota from H. pylori-infected patients may lead to the destruction of the intestinal barrier, thereby increasing the susceptibility to inflammatory bowel diseases [28].…”

Section: Possible Relationship Between the Interaction Of C Albicans And H Pylori With Gastrointestinal Floramentioning

confidence: 99%

“…The eradication of H . pylori can significantly increase the abundance of the gastric and downstream intestinal flora [ 30 ], such as Clostridium , Bacillus , etc., while the abundance of fungi such as yeast was significantly increased [ 31 ]. Disorders of the intestinal microbiota from H .…”

Section: Helicobacter Pylori Infection and Transmission Routesmentioning

confidence: 99%

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The cross-kingdom interaction between Helicobacter pylori and Candida albicans

et al. 2021

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Helicobacter pylori infection and transmission routesHelicobacter pylori is a gram-negative microaerophilic bacterium. The infection of H. pylori can increase the risk of gastric cancer which is the second leading cause of cancer death worldwide [1]. The World Health Organization's International Agency for Research on Cancer (IARC) has classified H. pylori as a type I (definite) carcinogen since 1994. H. pylori infection is a global health problem. In developed countries, its infection rate is 20% to 50%, while in developing countries, the infection rate of middle-aged people has reached 80% [2]. The fecaloral and the oral-oral routes are considered as the main transmission routes of H. pylori [3]. Nevertheless, only H. pylori genes have been detected in saliva and dental plaques, but culturable H. pylori has not been isolated yet in large quantities [4], indicating that there may be some new strategies of H. pylori to implement its transmission through oral cavity.Candida albicans, a dimorphic fungus, is one of the most common fungi in the human body [5]. It was noteworthy that C. albicans and H. pylori were abundant in certain human niches, such as the root canal necrotic pulp, stomach, duodenum, and vagina [6], suggesting that C. albicans may interact with H. pylori to promote the growth, spread, and infection of H. pylori in some nonadaptive condition, such as the oral cavity and vagina. The synergy between H. pylori and C. albicans in gastric diseasesH. pylori infection is positively correlated with yeast in gastric diseases [7]. A total of 36% gastric ulcers patients, 2% non-ulcerative dyspepsia patients, and 56% large-scale gastric ulcers (greater than 2 cm) patients with H. pylori have fungal co-colonization in the upper gastrointestinal tract, such as C. albicans and Candida krusei, indicating the strong relationship between fungi and H. pylori in ulcerative lesions [8]. C. albicans is highly correlated with H. pylori in gastric cancer, peptic ulcer, and chronic gastritis patients. The gastric ulcer patient with C. albicans and H. pylori in the stomach developed even larger ulcers. The presence of C. albicans was closely related to the prolongation of gastric diseases by the increase of healing time and persistence of clinical symptoms [9,10]. The strong positive correlation between C. albicans and H. pylori in the development of gastric diseases indicates their synergistic pathogenesis [7]. C. albicans may enhance the colonization, toxicity, and pathogenicity of H. pylori especially in gastrointestinal diseases through adhesion and the formation of a mixed species, like that C. albicans promotes the pathogenicity of other bacteria [11].

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Section: Possible Relationship Between the Interaction Of C Albicans And H Pylori With Gastrointestinal Floramentioning

confidence: 99%

Section: Helicobacter Pylori Infection and Transmission Routesmentioning

confidence: 99%

The cross-kingdom interaction between Helicobacter pylori and Candida albicans

et al. 2021

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“…A relationship has been also demonstrated between the abundance of H. pylori in the stomach and intestinal microbiota. The abundance of H. pylori was associated with a lower amount of Bifidobacteria and a higher amount of Candida albicans in the intestine, as well as with the degree of dysbiosis in the intestine [34].…”

Section: Normal Gastric Microbiotamentioning

confidence: 96%

The uninvited guests of our microbiome: Helicobacter pylori and Epstein-Barr virus and their role in gastric cancerogenesis

Dzikowiec

Pastuszak-Lewandoska

2021

Postępy Higieny I Medycyny Doświadczalnej

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It is well established that human body is an ecosystem for numerous microorganisms: bacteria, fungi, eukaryotic parasites, and viruses. They form a “microbiome” that under conditions of homeostasis remains in a friendly mutual relationship with the host. However, the composition and diversity of this microbe community is dynamic and can be changed under the influence of environmental factors, such as diet, antibiotic therapy, lifestyle, and the host’s genotype and immunity. The result of gut microbiome dysbiosis can lead even to cancer. The aim of this review is the description of the healthy gastrointestinal microbiome and the role of two infectious agents: Gram-negative bacteria Helicobacter pylori and Epstein-Barr virus in the development of gastric cancer in terms of gut dysbiosis. H. pylori is the most important pathogen of gastric microbiome with clear impact on its diversity. Coinfection with Epstein-Barr virus causes chronic gastritis, and the inflammatory process is significantly increased. The process of carcinogenesis begins with chronic inflammation that causes atrophic gastritis, intestinal metaplasia, dysplasia, and finally cancer. It has been proven that chronic inflammatory infection caused by infectious agents increases the risk of stomach cancer. Molecular methods that are progressively used to explore the human microbiome provide hope that this knowledge will be used for future diagnoses and therapy in the state of its dysbiosis and in cases of gastric cancer.

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“…В исследовании антихеликобактерной активности пробиотиков отсутствуют методологические стандарты, которые необходимо регламентировать. В качестве рутинных методов оценки антагонистической активности пробиотиков к НР могут быть предложены метод двухслойного агара и капельный метод уже описанные ранее [18,49].…”

Section: проблемы и перспективыunclassified

Eradication therapy of helicobacteriosis with probiotics, problems, and prospects

Ermolenko

Молостова

Gladyshev

2021

jour

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Currently, there is an urgent question of optimizing the treatment of stomach diseases associated with Helicobacter pylori, due to the increasing resistance of the pathogen to antibiotics and the presence of side effects of standard therapy. To optimize it, it is proposed to use probiotics as an additional or monotherapy. The review presents the results of studies of anti-helicobacter activity by in vitro and in vivo systems, as well as an assessment of the clinical effectiveness of various probiotic strains of microorganisms in eradication therapy. Several mechanisms of action of probiotics in the treatment of HP-related diseases are discussed. The problems and prospects of using personalized therapy of helicobacteriosis with probiotics and autoprobiotics, based on strains obtained from the gastrointestinal tract, are indicated.

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Gastrointestinal Dysbiosis Accompanied of Helicobacter Pylori Infection and its Correction by Probiotic

Cited by 4 publications

References 0 publications

The cross-kingdom interaction between Helicobacter pylori and Candida albicans

The cross-kingdom interaction between Helicobacter pylori and Candida albicans

The uninvited guests of our microbiome: Helicobacter pylori and Epstein-Barr virus and their role in gastric cancerogenesis

Eradication therapy of helicobacteriosis with probiotics, problems, and prospects

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