Gastrointestinal distribution and absorption behavior of Eudragit-coated chitosan–prednisolone conjugate microspheres in rats with TNBS-induced colitis

Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug delivery

“…Among them, Eudragit ® L 100-55, a well known pharmaceutical excipient developed by the Röhm Company in Germany, has been widely used for the formulation of different oral dosage forms (e.g. tablet coating, tablet matrix, microspheres, nanoparticles) for colon-targeted drug delivery (Oosegi et al, 2008;Zakeri-Milani et al, 2009;Moustafine et al, 2006;Jelvehgari et al, 2010;Cetin et al, 2010).…”

Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells

“…26,[30][31][32] Orally delivered nanoparticles have been demonstrated to adhere to inflamed intestinal mucosa 33 and are effective in the treatment of experimental colitis. 34,35 Here we describe the fabrication, characterization, and in vitro testing of a biodegradable nanoparticulate drug delivery vehicle for retinoic acid composed of PLGA. We determined fabrication conditions and characterized the drug release profile and physical dimensions of our drug delivery vehicle.…”

Experimental design to predict process variables in the preparation of cellulose based sustained release microspheres system loaded with prednisolone-cyclodextrin complex

“…Even at a moderate-dose repeated administration of drug for prolonged period causes many side effects such as diabetes, hypertension, Cushing syndrome and osteoporosis [14]. Earlier investigators performed numerous works to evaluate the drug release characteristics of prednisolone loaded in microspheres [15][16][17][18], but no one has considered the mathematical model design of the process that involves various process-variables for prednisolone. Only a few investigators have reported the effect of process variables on the characteristics of microspheres that have been prepared by the emulsion solvent evaporation method [5,[8][9][10].…”