Gastrointestinal Disease Control After Histamine<sub>2</sub>‐Receptor Antagonist Dose Modification for Renal Impairment in Frail Chronically Ill Elderly Patients

Lackner, Thomas E.; Heard, T. C.; Glunz, Samantha; Gann, Nicole; Babington, M; Malone, Daniel C.

doi:10.1034/j.1600-0579.2003.00209.x

Cited by 7 publications

(1 citation statement)

References 27 publications

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“…Administration of H2‐blockers should be adjusted according to kidney function. Lack of attention to ranitidine dose adjustment in patients with declined renal function, may increase 1‐year all‐cause mortality …”

Section: Discussionmentioning

confidence: 99%

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Mousavi

Dashti‐Khavidaki

Khalili

et al. 2012

International Journal of Pharmacy Practice

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Section: Discussionmentioning

confidence: 99%

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Mousavi

Dashti‐Khavidaki

Khalili

et al. 2012

International Journal of Pharmacy Practice

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Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

Fisher

2017

Clin Drug Investig

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This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on the potential of ASDs to contribute to infections-bacterial, parasitic, fungal, protozoan and viral, particularly in the elderly, comprehensively and critically discusses the growing body of observational literature linking ASD use to a variety of enteric, respiratory, skin and systemic infectious diseases and complications (Clostridium difficile diarrhoea, pneumonia, spontaneous bacterial peritonitis, septicaemia and other). The proposed pathogenic mechanisms of ASD-associated infections (related and unrelated to the inhibition of gastric acid secretion, alterations of the gut microbiome and immunity), and drug-drug interactions are also described. Both probiotics use and correcting vitamin D status may have a significant protective effect decreasing the incidence of ASD-associated infections, especially in the elderly. Despite the limitations of the existing data, the importance of individualised therapy and caution in long-term ASD use considering the balance of benefits and potential harms, factors that may predispose to and actions that may prevent/attenuate adverse effects is evident. A six-step practical algorithm for ASD therapy based on the best available evidence is presented.

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Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review

et al. 2018

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Gastrointestinal Disease Control After Histamine₂‐Receptor Antagonist Dose Modification for Renal Impairment in Frail Chronically Ill Elderly Patients

Abstract: The findings suggest that the dose of H2RAs may be decreased based upon renal function in frail elderly patients without compromising GI disease control.

Cited by 7 publications

References 27 publications

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review

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Gastrointestinal Disease Control After Histamine2‐Receptor Antagonist Dose Modification for Renal Impairment in Frail Chronically Ill Elderly Patients

Abstract: The findings suggest that the dose of H2RAs may be decreased based upon renal function in frail elderly patients without compromising GI disease control.

Cited by 7 publications

References 27 publications

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review

Contact Info

Product

Resources

About

Gastrointestinal Disease Control After Histamine₂‐Receptor Antagonist Dose Modification for Renal Impairment in Frail Chronically Ill Elderly Patients