Gastrointestinal Delivery of Baculovirus Displaying Influenza Virus Hemagglutinin Protects Mice against Heterologous H5N1 Infection

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity

“…Together, these data indicate that nonadjuvanted sH5 3 antigen is able to elicit high titers of H5 cross-clade neutralizing antibody when administered using a prime/boost/boost regimen. Consistent with previous reports, 6,7,12 multiple immunizations of sH5 3 recombinant protein were required to generate consistently high neutralizing antibody titers.…”

“…6,7,12 Polyanhydride nanoparticles have been shown to be a versatile vaccine adjuvant/delivery platform capable of enhancing the immune response to recombinant proteins. [13][14][15] Polyanhydrides are biodegradable materials that provide sustained release kinetics of encapsulated antigens, resulting in long-lived, high-avidity antibody titers, even with suboptimal doses of antigen.…”

Adaptive Immune Responses Elicited by Baculovirus and Impacts on Subsequent Transgene Expression In Vivo

“…Beyond these applications, BV is also used as an expression vector for the treatment of various cancers, including hepatoma (9), melanoma (10), colon cancer (11), brain cancer (12)(13)(14)(15)(16), prostate cancer (17,18), and ovarian cancer (17). In addition, BV has been explosively developed as a vaccine expression/display vector against a variety of pathogens, including avian influenza virus (AIV) (19)(20)(21)(22), avian reovirus (23), pseudorabies virus (24), enterovirus 71 (25), Plasmodium berghei (26), and many others (for a review, see reference 1).…”

A recombinant protein containing highly conserved hemagglutinin residues 81-122 of influenza H5N1 induces strong humoral and mucosal immune responses

“…HA-based vaccines have been shown to elicit higher titers of neutralizing antibodies to prevent influenza virus infection in tested animals (15)(16)(17)(18), as well as human clinical trials (19)(20)(21)(22). The HA1 antigenic domain of HA has been demonstrated to induce an immune response equal to that of the full-size protein (23).…”