Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota–Immunity Axis?

Russo, Edda; Boem, Federico; Curini, Lavinia; Amedei, Amedeo

doi:10.1007/16833_2022_6

Cited by 2 publications

(3 citation statements)

References 131 publications

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“…Recently, increasing importance in CRC progression has been attributed to the gut microbiota (GM) [4] , [5] , [6] , [7] . In detail, the CRC “tumour microenvironment” (TME) sees a complex interaction occurring among the GM, the cancer-associated microbiome (oncobiome) and the immune system [7] , [8] . It is well established that approximately 95% of CRCs consist of adenocarcinomas that originate as colonic Adenomatous polyps (AP) [10] , [11] or adenomas.…”

Section: Introductionmentioning

confidence: 99%

From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy

Russo¹,

Gloria²,

Nannini³

et al. 2023

Neoplasia

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Section: Introductionmentioning

confidence: 99%

From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy

Russo¹,

Gloria²,

Nannini³

et al. 2023

Neoplasia

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“…The intestinal microenvironment, comprised of three elements (epithelium, local immune system, and intestinal microbiome), plays a crucial role in IBD development and in the process leading to CAC (9). Each of these elements is interconnected and crucial to maintaining gut homeostasis.…”

mentioning

confidence: 99%

“…modulate the functions of other cells, like fibroblasts, in cell contact-dependent ways; and iii. have an immunomodulatory role for intestinal epithelial cells, which is critical to maintaining the gut immune homeostasis in tumours (9).…”

mentioning

confidence: 99%

Editorial: The mechanism of immune cells in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC)

et al. 2023

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Editorial on the Research TopicThe mechanism of immune cells in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC)Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is characterized by intermittent chronic inflammation of the gastrointestinal tract, due to a dysregulated immune response against intestinal mucosa, leading to bowel damage (1, Russo et al.). In IBD, the sealed intercellular junctions are damaged, either from a primary barrier function defect or from severe inflammation. Excessive inflammatory response leads to continued deterioration of the epithelium and exposure to the intestinal microbiome (bacteria, fungi, viruses, and their genes living in the gut), thereby further worsening the inflammation (2, 3).Colitis-associated colorectal cancer (CAC) is the most critical IBD complication (Rubin et al.). The carcinogenesis in IBD is a multistep progression, due to increasing degrees of histologic, molecular, and endoscopic alteration, from no dysplasia against chronic inflammation to low-grade dysplasia to high-grade dysplasia and eventually neoplasia (4).In addition, inflammation and cancer are closely related, as it has been welldocumented (5, 6). It induces genetic and epigenetic alterations transmissible to epithelial cell progeny (7), promoting epithelial turnover. Finally, inflammationFrontiers in Immunology frontiersin.org 01

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Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota–Immunity Axis?

Cited by 2 publications

References 131 publications

From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy

From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy

Editorial: The mechanism of immune cells in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC)

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