Gastrointestinal Blood Flow in the Dog

Delaney, John P.; Custer, James

doi:10.1161/01.res.17.5.394

Cited by 48 publications

(29 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It may be that the duodenum is functionally different from the jejunum. However, we should note that duodenal and jejunal blood flows are comparable (Delaney & Custer, 1965). Our own work also indicates that resting heat production is similar in the two regions (Durotoye & Grayson, 1971).…”

Section: Discussionsupporting

confidence: 49%

Effect of nicotine on blood flow, oxygen consumption and glucose uptake in the canine small intestine

Grayson

Oyebola

1985

British J Pharmacology

View full text Add to dashboard Cite

1 Resting blood flow, arterio-venous glucose and oxygen (A-V)02 differences, glucose uptake and oxygen consumption by a segment of the upper jejunum were measured in anaesthetized dogs. Systemic arterial pressure was also measured. 2 The effect of nicotine infusion (25 pg kg-' i.v., over 10 min) on these measurements was recorded in untreated dogs, in dogs treated with propranolol (0.5 mg kg-') to produce P-adrenoceptor blockade and in dogs after a,-adrenoceptor blockade with prazosin (0.2 mg kg-').3 Nicotine cause a significant pressor response during infusion and a hypotensive response during the post infusion period. Propranolol did not significantly affect these results. Jejunal blood flow increased in the first half of nicotine infusion in both the untreated and P-blocked animals. Vascular resistance was reduced during nicotine infusion and the decrease persisted post infusion in the P-blocked group. 4 In the untreated group (A-V)O2 was significantly reduced during the first 5min of nicotine infusion, thereafter it returned to control levels, then rose significantly above control level, post infusion. P-Adrenoceptor blockade had little effect on these responses to nicotine. When oxygen consumption was calculated it was found that nicotine had little effect during or after infusion. 5 Nictine caused significant hyperglycaemia during and for about 1 h after infusion. Tissue release of glucose was occasionally observed following the infusion. 13-Adrenoceptor blockade reduced the hyperglycaemia caused by nicotine. P-Blockade alone increased glucose uptake and nicotine caused a further three to four fold increase. Prazosin abolished the effects that were observed in the untreated and the a-blocked animals. 6 The present findings, related to our previous observations on the effects of catecholamines on glucose uptake by the bowel, are consistent with the hypothesis that nicotine has its action on bowel glucose uptake or release through its well-established action in releasing catecholamines and in activating P-adrenoceptors. The responses are not related to oxygen utilization.

show abstract

Section: Discussionsupporting

confidence: 49%

Effect of nicotine on blood flow, oxygen consumption and glucose uptake in the canine small intestine

Grayson

Oyebola

1985

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…The rela tively good agreement between calculated and determined (table 2) values for bile acid concentration in portal blood suggests the same relative blood flow reported previously [6,9], The present study shows that the distal small intestine was by far the major site of bile acid absorption tunneling as much as 73.8% of total bile acid during enterohepatic circulation. Bile acid absorption from the large intestine constituted only 9.4%.…”

Section: Discussionsupporting

confidence: 90%

“…In dog, the small intestinal blood flow was about four times larger than that of the large intestine [6], It was also reported that the proximal and distal small and large intes tines receive a blood flow per gram tissue approximately in the same order [6,9]. As shown in table 3, the mean total bile acid concentration is 49.8 nmol/ml in the proxi mal small intestine, 219.5 nmol/ml in the distal small intestine, 50.1 nmol/ml in the proximal large intestine and 61.8 nmol/ml in the distal large intestine.…”

Section: Discussionmentioning

confidence: 92%

“…In order to ascertain whether the assump tion is acceptable, the mean total bile acid concentration determined in serum from the portal trunk (114.3 nmol/ml, table 2) was compared with the calculated concentration, which was obtained from the mean total bile acid concentration in sera from four portal branches (table 3) and respective blood flow reported [6,9], It gave 118.9 nmol/ml [(49.8 X 4 + 219.5 X 4 + 50.1 X 1 +61.8 X 1)/10], Similarly, the mean cholic acid concentra- tion in the portal trunk was calculated to be 80.6 nmol/ml, chenodeoxycholic acid 5.1 nmol/ml, deoxycholic acid 32.5 nmol/ml and lithocholic acid 0.5 nmol/ml. The rela tively good agreement between calculated and determined (table 2) values for bile acid concentration in portal blood suggests the same relative blood flow reported previously [6,9], The present study shows that the distal small intestine was by far the major site of bile acid absorption tunneling as much as 73.8% of total bile acid during enterohepatic circulation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Absorption of Bile Acids in Dog as Determined by Portal Blood Sampling: Evidence for Colonic Absorption of Bile Acid Conjugates

Fujii

Yanagisawa²,

Nakayama³

1988

Digestion

View full text Add to dashboard Cite

The intestinal phase of enterohepatic circulation, such as site and state of bile acid absorption, along the length of the intestinal tract has been speculated but not directly quantitated. In order to gain insight into the actual state of intestinal absorption of bile acid, the bile acid composition of portal blood from various segments of the intestinal tract was studied in dogs after loading endogenous bile acid by injection of caerulein. Total and unconjugated bile acids were determined with and without enzymatic hydrolysis, respectively. The amount of conjugated bile acids was calculated by subtracting unconjugated from total bile acids. Quantitation of cholic, chenodeoxycholic, deoxycholic and lithocholic acids and their conjugates was carried out by gas chromatography/mass spectrometry/selected ion monitoring with deuterated bile acids as internal standards. The major site of absorption of taurine-conjugated bile acid, a major conjugate form in the dog, was the distal small intestine. In addition, a considerable amount of cholic acid was found to be absorbed from the distal large intestine, the majority of which was still in the conjugated form. The pronounced absorption of the unconjugated secondary bile acid from the large intestine suggests the very active formation of the secondary bile acid in situ.

show abstract

“…5DANIhLE AUGIER AND OTHERS Jones, 1960;Delaney & Custer, 1965). However, it is not known whether these alterations are actually involved in the regulation of the secretary process.…”

Section: Introductionmentioning

confidence: 99%

Relationships between blood flow and secretion in the isolated perfused canine pancreas

Augier¹,

Boucard²,

Pascal³

et al. 1972

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Stimulation by a continuous intra-arterial infusion of secretin caused a marked vasodilatation in the pancreato-duodenal preparation or in the isolated pancreas perfused with whole heparinized blood. There was no difference in the vasomotor effects of two unequally purified preparations of secretin. The fact that the vasodilatation was still observed when the duodenum was removed proved that the haemodynamic effect of secretin was initiated in the pancreas itself.2. The secretary response of the pancreas to a given dose of secretin was larger when the blood pressure was kept constant by increasing the blood flow than when the blood pressure was allowed to fall by maintaining the blood flow at a fixed value. It is concluded that the vasodilatation plays a role in the functional regulation of the pancreatic response to secretin. 3. The correlation between blood flow and arterial pressure on the one hand, and the secretary response to secretin on the other, was not mediated by the control of respiration since there was no variation in oxygen uptake in response to a variation in the blood flow. This correlation was still observed when the venous blood was discarded and therefore could not be explained by variations in the rate of recirculation of secretin. It was observed too in experiments where the duodenum was removed, the pancreas alone being introduced into the perfusion apparatus, which indicated that this effect was not mediated by a control of the release of secretin by the duodenum.

show abstract

Gastrointestinal Blood Flow in the Dog

Cited by 48 publications

References 5 publications

Effect of nicotine on blood flow, oxygen consumption and glucose uptake in the canine small intestine

Effect of nicotine on blood flow, oxygen consumption and glucose uptake in the canine small intestine

Absorption of Bile Acids in Dog as Determined by Portal Blood Sampling: Evidence for Colonic Absorption of Bile Acid Conjugates

Relationships between blood flow and secretion in the isolated perfused canine pancreas

Contact Info

Product

Resources

About