Gastrointestinal Bleeding in a Type 1 Neurofibromatosis Patient

Ku, Ming-Chang; Tsai, Chun-Chou; Tyan, Yeu–Sheng

doi:10.1053/j.gastro.2010.05.086

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the first published article in 1972–2013 we identified 25 articles reporting 25 patients with von Recklinghausen's disease who underwent laparotomy for acute intestinal obstruction , and with the addition of three patients from our institution (Table ) the mean age was 44.2 (0.5–73) years. The male/female ratio was approximately 1/1.…”

Section: Resultsmentioning

confidence: 99%

Intestinal obstruction in von Recklinghausen's disease

Trilling

Faucheron

2014

Colorectal Disease

View full text Add to dashboard Cite

Aim Gastrointestinal manifestations occur in up to 25% of patients with neurofibromatosis type 1. This review reports all published cases of acute intestinal obstruction due to neurofibromatosis type 1 and identifies mechanisms of obstruction, the nature of the tumour and the outcome. Method A systematic review of the literature on acute intestinal obstruction due to neurofibromatosis type 1 was performed by searching the major electronic databases. All relevant references were reviewed for possible inclusion. All the references of the relevant articles were screened for any further articles that were missed in the initial search. Results We identified 25 articles from 1972 to 2013 reporting 25 patients with von Recklinghausen's disease who underwent laparotomy for acute intestinal obstruction. Three further patients were operated on in our institution. The mean age of the patients was 44.2 years and the male/female ratio 15/13. The mechanisms of obstruction were intrinsic obstruction (16), extrinsic obstruction (8) and intussusception (4). Histology was reported to show neurofibroma (19), gastrointestinal stromal tumour (5) and adenocarcinoma (4). Among patients whose outcome was mentioned (17), 10 were asymptomatic after a mean follow‐up of 1.5 years. Conclusion Acute bowel obstruction is a rare manifestation of neurofibromatosis type 1. Surgery is often necessary to treat the complication and to determine the exact nature of the tumour and the prognosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Intestinal obstruction in von Recklinghausen's disease

Trilling

Faucheron

2014

Colorectal Disease

View full text Add to dashboard Cite

show abstract

“…The lesions consist of an overgrowth of neural tissue along with other mesenchymal elements. Gastrointestinal tumours may present with complications such as haemorrhage , perforation and very rarely obstruction . This case is the second report of a type 1 neurofibromatosis patient with a compressive pelvic mass that was responsible for urinary and rectal retention, the first one being due to a neurofibrosarcoma .…”

mentioning

confidence: 81%

Surgery for a large obstructive pelvic tumour associated with neurofibromatosis

Faucheron

Trilling²

2013

Colorectal Disease

View full text Add to dashboard Cite

Jejunojejunal intussusception with chronic bleeding caused by gastrointestinal stromal tumor: a case report and literature review

Li¹,

Ren²,

Sun³

et al. 2022

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: Intussusception is a rare clinical condition in adults. The majority of patients present with symptoms of bowel obstruction. Intussusception is often misdiagnosed and the majority of cases are diagnosed intraoperatively. In this paper, we present a rare case of adult jejunojejunal intussusception with chronic bleeding caused by a gastrointestinal stromal tumor (GIST). We emphasize the role of contrastenhanced computed tomography (CT) and enteroscopy in the presurgical diagnosis and the good prognosis in the high-risk GIST patient after surgery and targeted therapy.Case Description: Herein, we present the case of a 63-year-old female patient with small bowel intussusception with chronic bleeding caused by a GIST. Her main symptoms were intermittent melena and progressive anemia. She had a 20-year history of hypertension and had never undergone previous abdominal surgery. After failure of an esophagogastroduodenoscopy and colonoscopy to locate the hemorrhagic foci in the gastrointestinal tract, contrast-enhanced CT and enteroscopy were used and a small bowel intussusception and an intraluminal mass with a bleeding ulcer was identified. The patient underwent laparoscopic partial small bowel resection, and postoperative pathological examinations showed a small intestinal GIST with a high risk of recurrence. It was suggested that the patient take imatinib regularly for at least 3 years. At the time of writing, she has remained in good health without relapse for 24 months after discharge. We also review 20 published cases of intussusception caused by small bowel GIST in the PubMed database.Conclusions: Obscure gastrointestinal hemorrhage needs meticulous examinations to promptly determine the cause and location of bleeding. This case and literature review revealed that comprehensive surgical resection-centered treatment was the standard treatment for primary localized GISTs in patients at significant risk of relapse.

show abstract

Gastrointestinal Bleeding in a Type 1 Neurofibromatosis Patient

Cited by 4 publications

References 2 publications

Intestinal obstruction in von Recklinghausen's disease

Intestinal obstruction in von Recklinghausen's disease

Surgery for a large obstructive pelvic tumour associated with neurofibromatosis

Jejunojejunal intussusception with chronic bleeding caused by gastrointestinal stromal tumor: a case report and literature review

Contact Info

Product

Resources

About