Gastrointestinal basidiobolomycosis in children: an overlooked emerging infection?

El-Shabrawi, Mortada; Kamal, Naglaa Mohamed

doi:10.1099/jmm.0.028670-0

Cited by 42 publications

(55 citation statements)

References 40 publications

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“…A recent review of the literature revealed 26 GIB cases including 14 adults and 12 children [9]. All such cases presented with symptoms similar to our patients, and most were initially misdiagnosed as neoplasms or other inflammatory diseases [9].…”

Section: Discussionmentioning

confidence: 65%

Surgical management of gastrointestinal basidiobolomycosis in pediatric patients

Al-Shanafey

AlRobean

Hussain

2012

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 65%

Surgical management of gastrointestinal basidiobolomycosis in pediatric patients

Al-Shanafey

AlRobean

Hussain

2012

Journal of Pediatric Surgery

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“…The mode of transmission is not absolutely confirmed but seems to be via major trauma and insect bites. The organism can also be transmitted from soil or vegetation that is contaminated with animal faeces (El-Shabrawi & Kamal, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Most cases have been reported from tropical and subtropical regions of South America, Africa and Asia (El-Shabrawi & Kamal, 2011). Visceral involvement of B. ranarum in immunocompetent hosts is very rare.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal basidiobolomycosis, an emerging infection in the immunocompetent host: a report of 14 patients

Geramizadeh

Foroughi

Keshtkar-Jahromi

et al. 2012

Journal of Medical Microbiology

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Zygomycosis is characterized by tissue invasion with broad, non-septate hyphae of species such as Rhizopus, Rhizomucor, Lichtheimia (Absidia) and Basidiobolus. Basidiobolus ranarum usually causes subcutaneous infection, and gastrointestinal manifestations in immunocompetent patients have rarely been reported. It is difficult to diagnose gastrointestinal basidiobolomycosis because of the non-specific clinical presentation and the absence of a definite risk factor. This study identified 14 cases of gastrointestinal basidiobolomycosis, all of which were diagnosed after surgery by characteristic histopathological findings. Diagnosis of this disease requires a high index of suspicion in patients presenting with abdominal symptoms, fever, gastrointestinal mass and eosinophilia accompanied by a high erythrocyte sedimentation rate.

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“…The organism tends to be resistant to amphotericin B [16,19,36]. In the review by Vikram et al [19], eight deaths occurred among four-four patients (18%) with five of the fatalities being children [16-19,42-44]. Common features of the fatal cases were intestinal perforation and/or extensive abdominal spread of the disease [18,43].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan

Hassan¹,

Majid²,

Rashid³

et al. 2013

BMC Infect Dis

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BackgroundDeep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment.MethodsThe study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus.ResultsFourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from abdominal surgeries. Two children and four adults had abscesses that formed GI masses. These patients included a 39 year old male with oropharyngeal and transverse colon disease, and a 48 year old male with liver and GI abscesses. All sites demonstrated a Zygomycete fungus surrounded by eosinophilic Splendori-Hoeppli material consistent with basidiobolomycosis. Five of the six patients with fungal disease were treated by surgery and 4 to 7 months of itraconozol. One child died of intestinal perforation while receiving IV amphotericin B; two adults required additional surgery for recurrent GI obstruction. Eight patients had isolated liver abscesses with no organisms identified by histopathology: ELISA results for F. hepatica were positive for five, borderline for one, and negative for two patients. These eight patients were treated for fascioliasis by surgical resection of localized abscesses and albendazol. One patient serologically positive for F. Hepatica was found to have a common duct fluke two years after initial diagnosis. Serological testing for Toxocara and Echinococcus granulosus was negative in all 14 patients.ConclusionsBasidiobolomycosis and F. hepatica are implicated as the cause of abdominal eosinophilic granulomatous abscesses in 12 of 14 patients identified over a period of 40 months in northern Iraq. Treatment was complicated by chronic biliary tract disease in fascioliasis and perforation and recurrent intestinal obstruction with basidiobolomycosis.

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Gastrointestinal basidiobolomycosis in children: an overlooked emerging infection?

Cited by 42 publications

References 40 publications

Surgical management of gastrointestinal basidiobolomycosis in pediatric patients

Surgical management of gastrointestinal basidiobolomycosis in pediatric patients

Gastrointestinal basidiobolomycosis, an emerging infection in the immunocompetent host: a report of 14 patients

Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan

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