Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite

Sobko, Tanja; Reinders, Claudia; Jansson, Emmelie Å.; Norin, Elisabeth; Midtvedt, Tore; Lundberg, Jon O.

doi:10.1016/j.niox.2005.08.002

Cited by 133 publications

(106 citation statements)

References 124 publications

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“…reuteri strains, like other lactobacilli, are fastidious and rely on the availability of easily fermentable sugars, amino acids, vitamins, and nucleotides. If these factors are provided, the organisms grow very fast (duplication times of less than an hour), and L. reuteri can use several external electron acceptors (fructose, glycerol, nitrate) to gain additional energy and increase growth rates (57)(58)(59). The growth requirements of L. reuteri are satisfied in the proximal digestive tracts of rodents, pigs, and chickens as substrates get supplied through the diet.…”

Section: Lactobacillus Reuteri As a Model Gut Symbiontmentioning

confidence: 99%

Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm

Walter

Britton

Roos

2010

Proc. Natl. Acad. Sci. U.S.A.

282

279

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Vertebrates engage in symbiotic associations with vast and complex microbial communities that colonize their gastrointestinal tracts. Recent advances have provided mechanistic insight into the important contributions of the gut microbiome to vertebrate biology, but questions remain about the evolutionary processes that have shaped symbiotic interactions in the gut and the consequences that arise for both the microbes and the host. Here we discuss the biological principles that underlie microbial symbiosis in the vertebrate gut and the potential of the development of mutualism. We then review phylogenetic and experimental studies on the vertebrate symbiont Lactobacillus reuteri that have provided novel insight into the ecological and evolutionary strategy of a gut microbe and its relationship with the host. We argue that a mechanistic understanding of the microbial symbiosis in the vertebrate gut and its evolution will be important to determine how this relationship can go awry, and it may reveal possibilities by which the gut microbiome can be manipulated to support health.vertebrate symbiont | microbiota | mutualism

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Section: Lactobacillus Reuteri As a Model Gut Symbiontmentioning

confidence: 99%

Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm

Walter

Britton

Roos

2010

Proc. Natl. Acad. Sci. U.S.A.

282

279

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“…Homologous components for nitrate/nitrite transport are largely unknown in organisms, but there is some evidence of nitrite transport via a Cl − / HCO 3 − exchanger [119] which is member of the bicarbonate transporter family (SLC4). Nevertheless, it has been shown that dietary nitrate [86,120,121] as well as symbiotic and/or pathogenic bacteria immobilized nitrate [88,[122][123][124] may play an important role in the formation of nitrite at pathogenic and normal levels and consequently in regulating NO pools in higher organisms.…”

Section: No Oxidation Product and Nitrite Reductase Substrate Nitritmentioning

confidence: 99%

Bioanalytical profile of the l-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis

Boudko

2007

Journal of Chromatography B

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This review briefly summarizes recent progress in fundamental understanding and analytical profiling of the L-arginine/nitric oxide (NO) pathway. It focuses on key analytical references of NO actions and on the experimental acquisition of these references in vivo, with capillary electrophoresis (CE) and high-performance capillary electrophoresis (HPCE) comprising one of the most flexible and technologically promising analytical platform for comprehensive high-resolution profiling of NO-related metabolites. Second aim of this review is to express demands and bridge efforts of experimental biologists, medical professionals and chemical analysis-oriented scientists who strive to understand evolution and physiological roles of NO and to develop analytical methods for use in biology and medicine.

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“…Under certain circumstances, the health of a subsystem can degrade. Think of the case where predominant bacteria is accumulated in the stomach resulting in the reduction of nitrate and nitrite (Sobkoa, 2005), the bacteria will continue to grow while the environmental conditions remain unchanged and before they run out of space or nutrients. In this particular example, PHM can be used to model the growth of bacteria inside the stomach and how digestion is affected such that a number of corrective actions can be taken before the situation worsens.…”

Section: Introductionmentioning

confidence: 99%