Gastrointestinal autonomic nerve tumors: A clinicopathological, immunohistochemical and ultrastructural study of 10 cases

Segal, Amanda; Carello, Salvatore; Caterina, P.; Papadimitriou, John; Spagnolo, Dominic V.

doi:10.1080/00313029400169162

Cited by 44 publications

(46 citation statements)

References 23 publications

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“…However, our cases lacked any of the typical features of gastrointestinal schwannomas, such as cellular palisading and lymphoid cuffs at the periphery. Rather, they closely resembled the tumors described as plexosarcomas, or GANT [22,31,58]. It nevertheless appears that GANTs constitute a subset of CD117-positive GISTs with coexpression of neural antigens [32,57], which bans our glial/schwannian tumors from this category.…”

Section: Discussionmentioning

confidence: 96%

Gastrointestinal mesenchymal tumors – immunophenotypic classification and survival analysis

et al. 2002

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The current definition of gastrointestinal tumors (GIST) as CD117-positive mesenchymal tumors of uncertain malignant potential fails to include a number of cases with similar histology. In an attempt to improve the classification of these neoplasms, we conducted an immunohistochemical analysis of 244 mesenchymal tumors with histological features of GIST. According to their immunophenotype, the tumors were classified as GISTs, which are characterized by CD117 (c-kit) expression; gastrointestinal CD117-negative CD34 positive stromal tumors (GINST); alpha-smooth muscle actin and/or desmin positive gastrointestinal leiomyogenic tumors (GILT); S-100 and glial fibrillary acidic protein positive gastrointestinal glial/schwannian tumors (GIGT); gastrointestinal neuronal/glial tumors (GINT), which are positive for S-100/glial fibrillary acidic protein plus neuronal/glial markers; and gastrointestinal fibrous tumors (GIFT), which are only vimentin positive. The most common type of tumors were GIST, followed in order of frequency by GINST, GILT, GIGT, GIFT, and GINT. GISTs did not show any preferential location, whereas GINSTs occurred almost exclusively in the stomach and duodenum, and GILTs preferentially in the large intestine. Over a median follow-up period of 71 months, malignant behavior, i.e., metastatic spread, was observed in all tumor types except GINTs. Malignancy was associated with distal gut location, high mitotic activity, large tumor size, and nuclear pleomorphism, though none of these criteria alone discriminated between benign and malignant. Kaplan-Meier analysis of disease-specific survival showed significant differences in the long-term outcome of the newly defined subgroups. We conclude that, despite strong morphological similarities, gastrointestinal mesenchymal tumors are heterogeneous in their immunophenotype and biology.

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Section: Discussionmentioning

confidence: 96%

Gastrointestinal mesenchymal tumors – immunophenotypic classification and survival analysis

et al. 2002

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“…13 In addition, GANTs often demonstrate an epithelioid appearance, and sometimes are observed predominantly in the tumor. [14][15][16][17] To make a final microscopic diagnosis, IHC is thus an invaluable tool. In many experiments, several authors 12,[18][19][20][21][22] have reported the usefulness of S-100 IHC to distinguish schwannoma from smooth-muscle tumors.…”

Section: Discussionmentioning

confidence: 99%

Solitary Schwannoma of the Colon: Report of Two Cases

Inagawa¹,

Hori²,

Shimazaki³

et al. 2001

Surgery Today

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Some patients with gastrointestinal schwannoma (GIS) have been previously reported in the literature. However, GIS of the colon is quite rare. In addition, it is sometimes difficult to differentiate neurogenic tumors from other soft tissue tumors. We herein describe two cases of schwannoma of the colon, while also reviewing the relevant Japanese literature. The first case, a 73-year-old woman underwent a sigmoidectomy with lymph node dissection following the diagnosis of submucosal tumor. In the second case, a submucosal tumor was located in the cecum of a 44-year-old man. An endoscopic tumor resection was performed in the second case. The resected tumors measured 3.6 and 1.0 cm in maximal diameter, respectively. Microscopically, the tumors consisted predominantly of spindle-shaped cells that proliferated in an interlaced fashion. Mitosis was rarely seen in these tumors. Immunohistochemically, the tumor cells were strongly positive for S-100 protein, weakly positive for glial fibrillary acidic protein, and negative for CD34, alpha-smooth-muscle actin, and cytokeratin (CAM 5.2) in both cases. The tumors in the two cases were both diagnosed to be benign schwannoma of the colon. In general, schwannoma of the gastrointestinal tract is considered to be benign and should therefore be distinguished from other spindle-cell tumors or malignancies. Once diagnosed as schwannoma, extensive surgery should be avoided. Actually, such patients tend to show a good postoperative course with no evidence of recurrence.

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“…Although originally believed to be a distinct tumour, recent evidence supports the concept that GANTs represent a phenotyptic variant of GISTs (Segal et al, 1994). These tumours tend to be KIT positive and a most have gain of function mutation in the juxtamembrane domain of c-kit (Lee et al, 2001).…”

Section: Gastrointestinal Autonomic Nerve Tumoursmentioning

confidence: 99%

“…GANTs are uncommon tumours which can occasionally develop in the context of von Recklinghausen's disease (Lespi & Drut, 1997) and Carney's triad (Segal et al, 1994). Familial multiple GANTs have been described in an association with intestinal neuronal dysplasia (O'Brien et al, 1999).…”

Section: Gastrointestinal Autonomic Nerve Tumoursmentioning

confidence: 99%

Gastrointestinal Stromal Tumours: A Contemporary Review on Pathogenesis, Morphology and Prognosis

Sabah¹

2011

Soft Tissue Tumors

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Gastrointestinal autonomic nerve tumors: A clinicopathological, immunohistochemical and ultrastructural study of 10 cases

Cited by 44 publications

References 23 publications

Gastrointestinal mesenchymal tumors – immunophenotypic classification and survival analysis

Gastrointestinal mesenchymal tumors – immunophenotypic classification and survival analysis

Solitary Schwannoma of the Colon: Report of Two Cases

Gastrointestinal Stromal Tumours: A Contemporary Review on Pathogenesis, Morphology and Prognosis

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