Gastrointestinal and renal complications in burned patients

Haberal, Mehmet; Ozdemir, Alaattin; Bayraktar, Ulas D.; Öner, Zübeyde; Bi̇lgi̇n, N

doi:10.1007/bf00192700

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Risk of bias is summarized in Supplementary Table 1 of the (cohort or case-control studies) and Supplementary Figure 1 of the (RCT studies). Among the 57 included studies, 22 were from North America ( 4 , 9 , 15 , 16 , 24 , 26 , 28 , 30 , 31 , 33 , 34 , 40 , 42 – 44 , 48 – 50 , 54 , 59 , 61 , 62 ), 18 were from Asia ( 5 , 7 , 19 , 21 – 23 , 25 , 36 – 38 , 41 , 46 , 47 , 51 , 52 , 58 , 64 , 67 ), 15 were from European countries ( 6 , 17 , 18 , 20 , 27 , 32 , 35 , 45 , 53 , 55 – 57 , 60 , 65 , 66 ), one was from South America ( 29 ), one was Africa ( 39 ). A total of 12 studies could not be used for analysis of the prevalence of RRT, seven of which only reported on RRT patients ( 9 , 18 , 34 , 37 , 38 , 43 , 45 ), four of which were RCT studies ( 40 , 41 , 51 ,…”

Section: Resultsmentioning

confidence: 99%

“…We analyzed 45 literatures that reported the prevalence of RRT in burn patients ( Table 2 ) ( 4 – 7 , 15 , 16 , 19 – 33 , 35 , 36 , 39 , 42 , 46 – 50 , 53 – 62 , 64 – 68 ). The prevalence rates of RRT were 8.34% (95% CI 7.18–9.5%) in all burn patients and 37.05% (95% CI 29.85–44.24%) in AKI patients.…”

Section: Resultsmentioning

confidence: 99%

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Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome

Duan

Cai

et al. 2021

Front. Med.

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Background: Renal replacement therapy (RRT) was often needed by some severe burn patients with acute kidney injury (AKI). The primary aim of this study was to review incidence rate and mortality of RRT in severe burn patients. Second aims were to review RRT complications and renal outcome.Methods: We searched multiple databases for studies published between 1 January 1960 and 31 December 2019. Studies about adult populations with burn injury, providing epidemiologic data on prevalence or mortality of RRT, were included.Results: A total of selected 57 studies, including 27,437 patients were enrolled in our analysis. The prevalence rates of RRT were 8.34% (95% CI 7.18–9.5%) in all burn patients and 37.05% (95% CI 29.85–44.24%) in AKI patients. The mortality of all burn patients with RRT was 65.52% (95% CI 58.41–72.64%). The prevalence rates of RRT in sample size≥100 group were 6.86% (95% CI 5.70–8.03%), which was lower than that of <100 group (17.61%, 95% CI 13.39–21.82%). With the increase of TBSA, the prevalence of RRT may have the increasing trend. The prevalence rates of RRT in Asian group was 12.75% (95% CI 9.50–16.00%), which was higher than that of European (10.45%, 95% CI 7.30–13.61%) and North America group (5.61%, 95% CI 4.27–6.95%). The prevalence rates of RRT in 2010–2019 group was 12.22% (95% CI 10.09–14.35%), which was higher than that of 2009–2000 group (5.17%, 95% CI 2.88–7.46%). The prevalence rates of RRT in 1989 and before group was the lowest, which was 1.56% (95% CI 0–3.68%). However, there was no significant correlation between the year of publication and the mortality of burn patients with RRT. Dialysis-requiring AKI in burn patients could increases the risk of chronic kidney disease progression and end-stage renal disease. About 35% of RRT patients need to maintain haemodialysis temporarily, even if they survive and leave hospital.Conclusions: The prevalence rate of RRT is about 6–8%; approximately, one-third of burn patients with AKI need RRT. The prevalence rate of RRT increased over time, but the mortality did not change. The prevalence rates of RRT in Asian group was higher than that of European and North America group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome

Duan

Cai

et al. 2021

Front. Med.

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“…AKI in the early stage of extensive burns can be brought by denatured proteins, cardiac insufciency, hypovolemia, and infammatory factors produced by tissue destruction and nephrotoxicity caused by drugs [25][26][27]. Severe sepsis is often seen as a signifcant reason for the occurrence of advanced AKI [28,29]. For a long time, hypovolemia and inadequate fuid resuscitation were seen to be the main factors of early AKI.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients

Jiang,

Zhang,

Zhang

et al. 2023

Emergency Medicine International

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Background. The extensive burns devastate trauma. The research was designed to analyse the predictive value of early platelet (PLT) indices on the development of acute kidney injury (AKI) after severe burns. Methods and Results. 186 patients with extensive burns (burn area ≥30%) were eventually involved. Multivariate analyses pointed out that platelet distribution width (PDW) in the first 24 h after admission was an independent risk factor for AKI, severe AKI, and RRT requirement in patients with severe burns, and AKI risk showed an increase of 30.9% per increase of 1% in PDW (OR = 1.309, CI, 1.075–1.594, and P = 0.007). It was found that the area under the ROC curve (AUC) of PDW predicting AKI was 0.735 and that the AUC value was 0.81 for AKI after combining PDW and blood urea nitrogen (BUN). Based on the cut-off value PDW = 17.7%, patients were divided into high- (PDW ≥17.7%) and low-risk (PDW <17.7%) groups. In the KM analysis, there was a higher cumulative incidence of AKI if patients were in a high-risk group (in 30 days); and the stages of AKI showed a linear upward trend (chi-square test for linear trend P < 0.001 ) as there was an increase in the risk level. Conclusion. The PDW level in the early stage serves as an important risk factor for AKI, severe AKI, and RRT requirement in extensive burns. When PDW >17.7%, burn patients are not only at a higher risk for AKI but may also have higher AKI severity. Due to low cost and wide availability, PDW has the potential to be the tool that can predict AKI in extensive burn patients.

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Outcome of acute kidney injury in severe burns: a systematic review and meta-analysis

et al. 2010

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Gastrointestinal and renal complications in burned patients

Cited by 6 publications

References 11 publications

Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome

Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome

Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients

Outcome of acute kidney injury in severe burns: a systematic review and meta-analysis

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