Gastrointestinal and Hepatic Manifestations

Hallegua, David S.; Venuturupalli, Swamy R.

doi:10.1016/b978-1-4377-1893-5.00033-9

Cited by 11 publications

(19 citation statements)

References 79 publications

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“…The exact prevalence of systemic lupus erythematosus (SLE)‐related peritonitis is not known. Peritonitis in lupus may be disease‐related or due to mesenteric vasculitis, malabsorption, intestinal pseudo‐obstruction, cholecystitis, intestinal perforation, appendicitis or pancreatitis 1 . Besides abdominal causes, ascites may also be caused by hypoalbuminemia, right heart failure, Budd‐Chiari syndrome, malignancy and infective pathology.…”

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confidence: 99%

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Massive ascites as a presenting feature of lupus

2012

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confidence: 99%

“…Among patients with serositis, pleuritis or pericarditis are common and peritonitis is rarely described 2,3 . Abdominal pain is described in 8–37% of SLE patients, but in most cases it is due to mesenteric vasculitis, pancreatitis or is unrelated to disease 1 . The occurrence of peritonitis over the life‐time in a SLE patient is about 8–11%.…”

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confidence: 99%

Massive ascites as a presenting feature of lupus

2012

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“…Pain was significantly more frequent complaint in APS patients in comparison to those with SLE. According to various authors, the incidence of abdominal pain in SLE patients ranges from 8 to 37% and the assessment of its cause is quite complex [35–41]. The more frequent detection of pain in our examined patients than that reported in the literature is most likely associated with the inclusion of APS patients in the study.…”

Section: Discussionmentioning

confidence: 72%

“…However, the same manifestations may be related to drug therapy. In his review, D. Hallegua noted that the incidence of nausea in SLE patients ranged from 11 to 38% [35]. This figure dropped to 8% after excluding patients with nausea caused by medication.…”

Section: Discussionmentioning

confidence: 99%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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Background. The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. Objective. To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. Methods. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction. Results. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage. Conclusion. There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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“…A prevalence of pancreatitis of up to 4% has been reported in lupus patients [4]. Breuer et al [5] reviewed 77 cases of lupus patients with pancreatitis complications.…”

Section: Discussionmentioning

confidence: 98%

A case of lupus-associated pancreatitis with ruptured pseudoaneurysms

et al. 2011

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Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Herein we report a case of SLE with the initial development of acute pancreatitis, subsequently complicated by bleeding pseudoaneurysms. A 55-year-old Japanese woman was admitted to our hospital for the treatment of SLE. During the course of treatment, she complained of upper abdominal pain. An abdominal computed tomography (CT) scan showed that the pancreas was diffusely enlarged, and she was diagnosed with acute pancreatitis. Her pancreatitis was resistant to glucocorticoid therapy and was subsequently associated with pancreatic pseudocysts and recurrent rupture of the pseudoaneurysms. After surgical drainage of the hemorrhagic pseudocysts, the patient's clinical condition gradually improved with intensive therapies. Our case indicates that lupus pancreatitis can be associated with the potentially fatal complication of recurrent bleeding of pseudoaneurysms.

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Gastrointestinal and Hepatic Manifestations

Cited by 11 publications

References 79 publications

Massive ascites as a presenting feature of lupus

Massive ascites as a presenting feature of lupus

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

A case of lupus-associated pancreatitis with ruptured pseudoaneurysms

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