Gastrointestinal and cardiac response to refeeding after low-calorie semistarvation

Young, Eleanor; Cantu, Teresa L; Harris, Merle M

doi:10.1093/ajcn/50.5.922

Cited by 10 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding of hypertrophied cardiomyocytes in M-sFR-Refed rats 3 months after refeeding (Fig. 2 ) is supported by a study of cardiomyocytes from male rats subjected to sFR for 3 weeks followed by a 3-week period of refeeding [ 13 ]. This study showed the protein/DNA ratio was increased after the 3-week refeeding period, suggesting a cellular hypertrophic adaptative response occurred during the refeeding period.…”

Section: Discussionsupporting

confidence: 80%

Susceptibility of female rats to cardiac arrhythmias following refeeding after severe food restriction

et al. 2022

View full text Add to dashboard Cite

Background Many studies have shown malnutrition and inadequate caloric consumption have adverse acute effects on cardiovascular structure and function. Methods To determine the adverse long term cardiovascular effects, we studied cardiac morphology and function in female (F) and male (M) severe food restricted rats 3 months after refeeding (sFR-Refed). Results Two weeks of a normal chow diet in which calories were reduced by 60% decreased body weight (BW) by approximately 15% in both sexes. Within 2 weeks of refeeding, no differences in BW were detected between CT and sFR-Refed groups. However, male rats gained almost 3 times more BW than the females over the 3-month refeeding period. Sex differences were also observed in cardiac pathology. Hearts from F-sFR-Refed rats exhibited more atrophy and less hypertrophy, while M-sFR-Refed rats predominantly exhibited hypertrophic remodeling. While there were no differences in the frequency of ventricular arrhythmias induced by ischemia/reperfusion (I/R) in the isolated heart between M-CT and M-sFR-Refed rats, I/R induced twice as many arrhythmias in the F-sFR-Refed rats compared to F-CT. Conclusions These findings indicate the female heart is more susceptible to the long term adverse cardiovascular effects of sFR months after refeeding. Thus, this study provides a rationale for studying sex differences in cardiovascular risk in individuals who experience sFR for voluntary (e.g., very low-calorie dieting) or involuntary (e.g., poverty) reasons earlier in life.

show abstract

Section: Discussionsupporting

confidence: 80%

Susceptibility of female rats to cardiac arrhythmias following refeeding after severe food restriction

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In normotensive rats submitted to food restriction, chronic refeeding decreased the incidence of cardiac arrhythmia and reversed the depletion of heart proteins. 21 , 22 Food restriction caused cardiac function disturbances that were almost completely reversed back to normal after chronic refeeding in the isolated rat heart. 23 In our laboratory, we observed that fasting/refeeding cycles reversed the mechanical dysfunction and attenuated the structural injuries in papillary muscles caused by CR in normotensive rats.…”

Section: Introductionmentioning

confidence: 98%

Fasting/Refeeding Cycles Prevent Myocardial Dysfunction and Morphology Damage in the Spontaneously Hypertensive Rats

Pinotti

Matias

Sugizaki

et al. 2018

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

BackgroundCaloric restriction is known to impair the cardiac function and morphology in hypertrophied hearts of spontaneously hypertensive rats (SHR); however, the influence of fasting/refeeding (RF) is unknown.ObjectiveTo investigate the fasting/refeeding approach on myocardial remodeling and function. In addition, the current study was designed to bring information regarding the mechanisms underlying the participation of Ca2+ handling and β-adrenergic system.MethodsSixty-day-old male SHR rats were submitted to food ad libitum (C), 50% food restriction (R50) or RF cycles for 90 days. Cardiac remodeling was assessed by ultrastructure analysis and isolated papillary muscle function. The level of significance considered was 5% (α = 0.05).ResultsThe RF rats presented lower cardiac atrophy than R50 in relation to C rats. The C rats increased weight gain, R50 maintained their initial body weight and RF rats increased and decreased weight during RF. The RF did not cause functional impairment because the isotonic and isometric parameters showed similar behavior to those of C. The isotonic and isometric cardiac parameters were significantly elevated in RF rats compared to R50 rats. In addition, the R50 rats had cardiac damage in relation to C for isotonic and isometric variables. While the R50 rats showed focal changes in many muscle fibers, the RF rats displayed mild alterations, such as loss or disorganization of myofibrils.ConclusionFasting/refeeding promotes cardiac beneficial effects and attenuates myocardial injury caused by caloric restriction in SHR rats, contributing to reduce the cardiovascular risk profile and morphological injuries. Furthermore, RF promotes mild improvement in Ca2+ handling and β-adrenergic system.

show abstract

“…In fact a significant decrease in cellmediated immunity has been observed during a 6-week VLED treatment [20]. Moreover, in an obese rat model VLEDs induced significant reductions in mucosal protein and DNA content [72].…”

Section: Are Vleds Adequate?mentioning

confidence: 99%

Who should undergo a very low energy diet?

Müller

Großklaus

1993

Clin Investig

View full text Add to dashboard Cite

Gastrointestinal and cardiac response to refeeding after low-calorie semistarvation

Cited by 10 publications

References 24 publications

Susceptibility of female rats to cardiac arrhythmias following refeeding after severe food restriction

Susceptibility of female rats to cardiac arrhythmias following refeeding after severe food restriction

Fasting/Refeeding Cycles Prevent Myocardial Dysfunction and Morphology Damage in the Spontaneously Hypertensive Rats

Who should undergo a very low energy diet?

Contact Info

Product

Resources

About