Gastrointestinal amyloidosis: radiologic features by chemical types.

Tada, Shuji; Iida, Mitsuo; Yao, Tsuneyoshi; Kawakubo, K; Fuchigami, Takeshi; Okada, Masamitsu; Fujishima, Makoto

doi:10.1148/radiology.190.1.8259424

Cited by 53 publications

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“…Our findings with CT agree with reports of barium studies that have described bowel wall thickening as a common abnormality in GI amyloidosis [4]. We also agree with radiologic [4] and autopsy [6] studies that have found the small bowel to be the most common site of involvement.…”

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

“…Tada et al [4] reported that fold thickening in AL is due to interstitial, not to vascular, involvement. They also reported that AL and AA have different appearances on enteroclysis, with AL more likely to produce polypoid defects [4]. Another study found that in AL diffuse dilatation is more likely to be due to muscularis propria infiltration and have a worse prognosis than in AA [5].…”

mentioning

confidence: 99%

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Amyloidosis of the alimentary canal: radiologic–pathologic correlation of CT findings

2000

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

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confidence: 99%

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Amyloidosis of the alimentary canal: radiologic–pathologic correlation of CT findings

2000

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“…The reported preferential types and locations of amyloid deposits are associated with the type of amyloid fibril protein (6,7). The AA type of amyloid protein is deposited mainly in the lamina propria mucosa of the GI tract.…”

Section: Discussionmentioning

confidence: 99%

Solitary Amyloidosis of the Sigmoid Colon Featuring Submucosal Tumor Caused Hematochezia

et al. 2013

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A previously a healthy 64-year-old woman complained of a two-week history of hemorrhaging upon defecation. The laboratory and urinalysis findings were normal, and no serum or urine M components were detectable on protein electrophoresis. An air contrast barium enema revealed an elevated lesion measuring -20 mm in diameter with a smooth surface and a depression in the sigmoid colon. Colonoscopy revealed a red colored and congested tumor. The exposed surface of the submucosal tumor (SMT) center was somewhat yellow in color and covered with fuzz. All other portions of the colon were normal. The endoscopy and double-contrast barium revealed a normal upper gastrointestinal tract and a normal small intestine, respectively. A histopathological evaluation of a biopsy specimen obtained from the SMT suggested amyloid deposition. However, the other biopsy specimens of the esophagus, stomach, duodenal bulb, second portion of the duodenum, terminal ileum and other portions of the colon demonstrated no amyloid deposition. Colonoscopic ultrasonography (US) revealed the hypoechoic, homogeneous SMT to be mainly localized within the submucosa. An endoscopic submucosal resection (EMR) of the solitary amyloidosis was performed and the immunohistopathology revealed the entire SMT to consist of amyloid light chain kappa amyloid deposition. We considered that the US followed by EMR contributed to the precise diagnosis of solitary amyloidosis and the treatment of hematochezia caused by a solitary area of amyloidosis within the sigmoid colon.

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“…According to the previous reports, small bowel is the most commonly involved organ in the gastrointestinal system (15,16). The most frequent imaging finding of small intestinal amyloidosis is regular thickening of the folds (focal or diffuse), which displays edema due to ischemia as a result of vascular accumulation.…”

Section: Radiologic Featuresmentioning

confidence: 99%

Imaging for abdominal involvement in amyloidosis

Özcan¹,

Haliloğlu²,

Sökmensüer³

et al. 2017

Diagn Interv Radiol

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Gastrointestinal amyloidosis: radiologic features by chemical types.

Abstract: Characteristic radiographic changes of each chemical type of amyloid protein can be detected well in the small intestine.

Cited by 53 publications

References 0 publications

Amyloidosis of the alimentary canal: radiologic–pathologic correlation of CT findings

Amyloidosis of the alimentary canal: radiologic–pathologic correlation of CT findings

Solitary Amyloidosis of the Sigmoid Colon Featuring Submucosal Tumor Caused Hematochezia

Imaging for abdominal involvement in amyloidosis

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