Gastrointestinal Adverse Events in a General Population Sample of Nursing Home Residents Taking Cholinesterase Inhibitors

Abstract

GI events generally occurred with similar frequency in a national sample of nursing home residents taking donepezil, galantamine, or rivastigmine in the usual clinical practice setting.

Safety and Tolerability of Donepezil, Rivastigmine and Galantamine for Patients with Alzheimer’s Disease: Systematic Review of the ‘Real-World’ Evidence

“…The study by Hughes et al [25] compared nursing home residents who may be more likely to have advanced AD than subjects in the general population. One study [34] was only available as an abstract and therefore reported limited study details, which resulted in a score of 4 on the NOS scale.…”

“…Six of the studies were retrospective analyses of patient medical records [23,24,30,33] or prescription databases [25,29] , and the remaining 6 were prospective open-label cohort studies [26-28, 31, 32, 34] .…”

“…Eleven studies were published in full [23][24][25][26][27][28][29][30][31][32][33] , and 1 was available as a conference abstract [34] . Three foreign-language publications with English abstracts were translated in order to extract relevant results [23,[29][30][31] .…”

“…Of the 12 relevant studies undergoing assessment for methodological quality, 1 was assessed to be of poor quality (score of 4 out of 9 on the NOS) [34] and 2 were found to be of moderate quality (range 5-6 out of 9 on the NOS) [24,25] . The study by Hughes et al [25] compared nursing home residents who may be more likely to have advanced AD than subjects in the general population.…”

“…Two additional full-text studies were identified via hand-searching. Therefore, 12 studies met the inclusion criteria, and were included in the systematic review [23][24][25][26][27][28][29][30][31][32][33][34] .…”