Gastroesophageal reflux-like symptoms are associated with hyposalivation and oropharyngeal problems in patients with asthma

Koshiyama, Setsuko; Tanimura, Kazuya; Ito, Kayoko; Funayama, Saori; Hira, Daiki; Komase, Yuko; Satô, Susumu

doi:10.1016/j.resinv.2020.06.004

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…A questionnaire study with 531 patients included showed that patients with hyposalivation significantly increased in age and had severe dry mouth and gastroesophageal reflux-like symptoms, and multivariate analysis results showed that advanced age and severe gastroesophageal reflux-like symptoms were independently associated with hyposalivation. 12 Esophageal hiatus hernia was an important factor for the occurrence of gastroesophageal reflux, 13,14 the size of which was related to the severity of GERD, 15 and which with a diameter greater than 3 cm was associated with severe reflux esophagitis. 16,17 The incidence of esophageal hiatus hernia increased with aging, and the meta-analysis results showed that esophageal hiatus hernia was associated with age above 50 years, with an OR of 2.71.…”

Section: Pathog Ene S Is Of G Erd In the Elderlymentioning

confidence: 99%

“…Compared with the young control group, middle‐aged and elderly subjects (>55 years old) showed a significant decrease in salivary and bicarbonate response to esophageal acid perfusion. A questionnaire study with 531 patients included showed that patients with hyposalivation significantly increased in age and had severe dry mouth and gastroesophageal reflux‐like symptoms, and multivariate analysis results showed that advanced age and severe gastroesophageal reflux‐like symptoms were independently associated with hyposalivation 12 …”

Section: Pathogenesis Of Gerd In the Elderlymentioning

confidence: 99%

Section: Pathogenesis Of Gerd In the Elderlymentioning

confidence: 99%

See 2 more Smart Citations

Chinese expert consensus on diagnosis and management of gastroesophageal reflux disease in the elderly (2023)

Fangxu,

Wenbin,

Pan

et al. 2024

Aging Medicine

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Gastroesophageal reflux disease (GERD) in the elderly is characterized by atypical symptoms, relatively severe esophageal injury, and more complications, and when GERD is treated, it is also necessary to fully consider the general health condition of the elderly patients. This consensus summarized the epidemiology, pathogenesis, clinical manifestations, and diagnosis and treatment characteristics of GERD in the elderly, and provided relevant recommendations, providing guidance for medical personnel to correctly understand and standardize the diagnosis and treatment of GERD in the elderly.

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Section: Pathog Ene S Is Of G Erd In the Elderlymentioning

confidence: 99%

Section: Pathogenesis Of Gerd In the Elderlymentioning

confidence: 99%

Section: Pathogenesis Of Gerd In the Elderlymentioning

confidence: 99%

See 1 more Smart Citation

Chinese expert consensus on diagnosis and management of gastroesophageal reflux disease in the elderly (2023)

Fangxu,

Wenbin,

Pan

et al. 2024

Aging Medicine

View full text Add to dashboard Cite

show abstract

“…A causal link between GERD and asthma is lacking. Gastroesophageal reflux disease was associated with hypo salivation and oropharyngeal problems in patients with asthma [93]. Another theory is that GERD may induce changes in the mucosal immune system that may favor the development of food allergy and allergic sensitization to aeroallergens.…”

Section: Statement 8 Gerd May Cause Respiratory Symptoms Due To Micro...mentioning

confidence: 99%

Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations

Drug

Antoniu

Oana

et al. 2022

JGLD

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Background and Aims: Gastroesophageal reflux disease (GERD) is a common condition present in daily practice with a wide range of clinical phenotypes. In this line, respiratory conditions may be associated with GERD. The Romanian Societies of Gastroenterology and Neurogastroenterology, in association with the Romanian Society of Pneumology, aimed to create a guideline regarding the epidemiology, diagnosis and treatment of respiratory conditions associated with GERD.Methods: Delphi methodology was used and eleven common working groups of experts were created. The experts reviewed the literature according to GRADE criteria and formulated 34 statements and recommendations. Consensus (>80% agreement) was reached for some of the statements after all participants voted.Results: All the statements and the literature review are presented in the paper, together with their correspondent grade of evidence and the voting results. Based on >80% voting agreement, a number of 22 recommendations were postulated regarding the diagnosis and treatment of GERD-induced respiratory symptoms. The experts considered that GERD may cause bronchial asthma and chronic cough in an important number of patients through micro-aspiration and vagal-mediated tracheobronchial reflex. GERD should be suspected in patients with asthma with suboptimal controlled or after exclusion of other causes, also in nocturnal refractory cough which needs gastroenterological investigations to confirm the diagnosis. Therapeutic test with double dose proton pump inhibitors (PPI) for 3 months is also useful. GERD induced respiratory conditions are difficult to treat; however,proton pump inhibitors and laparoscopic Nissen fundoplication are endorsed for therapy.Conclusions: This guideline could be useful for the multidisciplinary management of GERD with respiratory symptoms in current practice.

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Gastroesophageal reflux disease in chronic obstructive pulmonary disease

Tanimura,

Muro

2024

Respiratory Investigation

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Gastroesophageal reflux-like symptoms are associated with hyposalivation and oropharyngeal problems in patients with asthma

Cited by 4 publications

References 24 publications

Chinese expert consensus on diagnosis and management of gastroesophageal reflux disease in the elderly (2023)

Chinese expert consensus on diagnosis and management of gastroesophageal reflux disease in the elderly (2023)

Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations

Gastroesophageal reflux disease in chronic obstructive pulmonary disease

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