Gastroesophageal reflux in the infant with cystic fibrosis

Gastric emptying and different types of reflux in adult patients with cystic fibrosis

“…There was a significant correlation between oesophageal bile and acid exposure (P < 0.0001, r = 0.85). Patients with increased DGER had a higher proximal extent of reflux compared to those without DGER [17 (9-35) vs. 5 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), P = 0.04]. There was no correlation between GE and reflux parameters, however, in a subgroup of 10 patients studied by impedance-pH-Bilitec and GE, there was a strong correlation between GE rate and bile exposure (P = 0.005, r = 0.83).…”

“…Increased gastro‐oesophageal reflux (GER) in adult patients with cystic fibrosis (CF) was first reported in 1975 by Feigelson 1 . Using 24 h pH‐measurements, estimates of the prevalence of increased acid GER vary between 35 and 81% 2–5 . Combined impedance‐pH monitoring is a more sensitive technique for reflux detection, which enables us to detect both acid and weakly acidic reflux events 6 .…”

“…1 Using 24 h pH-measurements, estimates of the prevalence of increased acid GER vary between 35 and 81%. [2][3][4][5] Combined impedance-pH monitoring is a more sensitive technique for reflux detection, which enables us to detect both acid and weakly acidic reflux events. 6 Our group studied 33 adult CF patients using 24 h impedance-pH monitoring and found increased acid reflux in 64% of CF patients.…”

Gastroesophageal Reflux (Symptomatic and Silent): A Potentially Significant Problem in Patients With Cystic Fibrosis Before and After Lung Transplantation

“…1 Gastroesophageal reflux (GER) was first reported in cystic fibrosis (CF) in 1975, 2 and is common among children with CF. [3][4][5][6] Furthermore, children with CF and GER have poorer lung function than those without GER. 7 Limited data suggest that symptomatic GER is also problematic in adults with CF, with significantly longer and more frequent episodes while patients were supine compared with upright.…”

Postural drainage and gastro-oesophageal reflux in infants with cystic fibrosis

“…3 Estimates of the incidence of pathologically increased reflux vary between 35–81% 45Refluxed gastric contents may potentially impair pulmonary function through micro-aspiration and reflex spasm of the bronchi and glottis 6.…”