Gastroesophageal reflux in cirrhotic patients without esophageal varices

Zhang, Jun; Cui, Peilin; Li, Dong; Yao, Shiwei; Xu, Youqing; Yang, Zhao-Xu

doi:10.3748/wjg.v17.i13.1753

Cited by 15 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with cirrhosis and portal hypertension, gastroesophageal reflux occurs at a high frequency (64%) . A study including 78 cirrhotic patients without esophageal varices confirmed by upper gastroesophageal endoscopy revealed that the incidence of abnormal reflux and reflux esophagitis was 55.13% and 37.18%, respectively . In the present study, 77.88% of cirrhotic patients experienced one or more disturbing GI symptoms, with bloating being the most frequent symptom (prevalence rate, 40.38%).…”

Section: Discussionsupporting

confidence: 48%

“…In patients with cirrhosis and portal hypertension, gastroesophageal reflux occurs at a high frequency (64%). 29 A study including 78 cirrhotic patients 30 In the present study, 77.88% of cirrhotic patients experienced one or more disturbing GI symptoms, with bloating being the most frequent symptom (prevalence rate, 40.38%). The prevalence rate recorded in our study is similar to that reported by Fritz and Hammer.…”

Section: Risk Factors Of Depression and Anxiety In Cirrhosis E67mentioning

confidence: 55%

See 1 more Smart Citation

Female gender and gastrointestinal symptoms, not brain‐derived neurotrophic factor, are associated with depression and anxiety in cirrhosis

Hong

Zhou

et al. 2016

Hepatology Research

View full text Add to dashboard Cite

Aim: Cirrhosis places a substantial burden on the psychological status of affected individuals. The aim of our study was to identify the associated factors of psychological distress in cirrhosis.Methods: A total of 208 patients with cirrhosis were recruited.Each patient received validated questionnaires to assess gastrointestinal (GI) symptoms, depression, and anxiety. Serum brainderived neurotrophic factor (BDNF) levels were measured by enzyme-linked immunosorbent assay.Results: A total of 16.35% of patients (n = 34) were diagnosed with depression and 10.58% (n = 22) with anxiety. The percentages of female patients among those diagnosed with depression and anxiety were 58.8% and 77.3%, respectively, which were significantly higher than that in non-depressed (35.1%) and non-anxious patients (34.4%). The patients who showed more GI symptoms had higher depression and anxiety scores. The GI symptom scores of patients with depression and anxiety were 4 (2.75, 7) and 4 (2.75, 7.25), respectively, which were significantly higher than that of patients without depression (2 [0, 4]) and anxiety (2 [1, 4]). Significantly higher depression and anxiety scores were detected in patients who suffered from abdominal bloating, belching, anorexia, abdominal pain, nausea/vomiting, and constipation. Cirrhotic patients had higher serum levels of BDNF than healthy controls (159.33 [96.64, 243.30] pg/mL vs. 70.74 [56.58, 93.52] pg/mL). In the cirrhosis group, there was no significant difference in BDNF levels between depressed and non-depressed patients. Multiple linear regression analysis revealed that depression and anxiety were each independently associated with female gender and GI symptom scores.Conclusions: Female gender and GI symptoms are closely associated with depression and anxiety in cirrhosis. There is no significant correlation between BDNF level and psychological distress in cirrhosis.

show abstract

Section: Discussionsupporting

confidence: 48%

Section: Risk Factors Of Depression and Anxiety In Cirrhosis E67mentioning

confidence: 55%

Female gender and gastrointestinal symptoms, not brain‐derived neurotrophic factor, are associated with depression and anxiety in cirrhosis

Hong

Zhou

et al. 2016

Hepatology Research

View full text Add to dashboard Cite

show abstract

“…Of all patients in the study with ascites, 31.9% (36/ [11][12][13][14][15][16][17][18] for PPI nonusers, P = 0.06). Further investigation of the association between PPI use and increased risk of SBP development showed that PPI use increased the risk of SBP development only in patients who did not have a previous SBP episode (n = 84) ( Fig.…”

Section: Risk Factors Of Spontaneous Bacterial Peritonitismentioning

confidence: 99%

“…Several clinical trials demonstrated no improvement in the risk of portal hypertension-related bleeding with PPI treatment [11,12]. Another problem is that although in some studies GERD was more common in patients with cirrhosis as compared with a healthy population, the low sample size of these studies makes their results highly questionable [13,14]. Regardless of these uncertainties, PPIs are frequently prescribed for patients with cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Deleterious effect of proton pump inhibitors on the disease course of cirrhosis

Janka

Tornai

Borbély

et al. 2020

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

show abstract

“…The prevalence of GERD in liver cirrhosis patients was reported to be ranging between 55%-64%[ 13 , 14 ]. Zhang et al [ 13 ] assessed 78 cirrhotic patients without EV using esophageal manometry, simultaneous ambulatory 24-h esophageal pH, and bilirubin monitoring and esophagogastric duodenal endoscopy (EGD). The study showed that the resting LES pressure in cirrhotic patients was diminished.…”

Section: Liver Cirrhosis and Gerdmentioning

confidence: 99%