Gastroesophageal Reflux Disease Questionnaire (<scp>GerdQ</scp>) in real‐world practice: A national multicenter survey on 8065 patients

Bai, Yu; Du, Yiqi; Zou, Duowu; Jin, Zhendong; Zhan, Xianbao; Li, Zhao‐Shen; Yang, Yunsheng; Liu, Yulan; Zhang, Shutian; Qian, Jiaming; Zhou, Liya; Hao, Jianyu; Chen, Dongfeng; Fang, Dian‐Chun; Fan, Daiming; Yu, Xianjun; Sha, Weihong; Nie, Yongzhan; Zhang, Xiaofeng; Xu, Hong; Lv, Nonghua; Jiang, Bo; Zou, Xiaoping; Fang, Jing‐Yuan; Fan, Jian‐Gao; Li, Yan; Chen, Weichang; Wang, Bangmao; Zou, Yiyou; Li, Youming; Sun, Mingjun; Chen, Qi‐Kui; Chen, Minhu; Zhao, Xiao‐Fan

doi:10.1111/jgh.12125

Cited by 63 publications

(69 citation statements)

References 19 publications

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“…These findings suggest that though GERD-Q may be used to diagnose GERD, endoscopy is still needed for some patients in populations with a high prevalence of upper gastrointestinal malignancies, like the Chinese. 24 Based on this finding and on our results, we think that further studies should be performed in the Spanish population to assess the exact correlation between GERD-Q score and the presence of esophagitis, in order to validate the questionnaire as a diagnostic tool for use in routine clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…2,13,14,24,28 A recent study assessing the value of the GERD-Q found an association between higher GERD-Q scores and higher proportions of patients with reflux esophagitis. 24 However, the same study found that a low score could not rule out the possibility of reflux esophagitis, and also that a high score cannot exclude the possibility of upper gastrointestinal malignancies. These findings suggest that though GERD-Q may be used to diagnose GERD, endoscopy is still needed for some patients in populations with a high prevalence of upper gastrointestinal malignancies, like the Chinese.…”

Section: Discussionmentioning

confidence: 99%

“…A cut-off score of 8 points has the highest specificity and sensitivity when testing for GERD. 24 Information on treatment was collected by structured interview before the procedure. The medication taken during the last month was recorded, with a specific register of NSAIDs, acetyl salicylic acid (AAS) and other antiplatelet drugs, PPIs and histamine H2-receptor antagonists.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

et al. 2016

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Background: The current prevalence of esophagitis in southern Europe is unknown. In addition, the risk factors for reflux esophagitis are not fully understood. Objective: The objective of this article is to assess the prevalence and risk factors for esophagitis in Spain. Methods: A prospective, observational, cross-sectional, multicenter study (PRESS study) was conducted among 31 gastrointestinal endoscopy units throughout Spain. A total of 1361 patients undergoing upper gastrointestinal endoscopy were enrolled. Sociodemographic, clinical and treatment data were recorded. Results: A total of 95% of patients were Caucasian and 52% were male (mean age: 53 AE 17 years). The most frequent symptoms prompting endoscopy were heartburn (40%), regurgitation (26%) and dysphagia (15%). Fifty-four percent of patients undergoing endoscopy were receiving proton pump inhibitor (PPI) treatment. Esophagitis (mainly mild-moderate) was present in 154 (12.4%) patients. The severe form was recorded in only 11 (0.8%) patients. Multivariate analysis results indicated that the likelihood of esophagitis was higher in men (OR ¼ 1.91, 95% CI ¼ 1.31-2.78), in patients with high GERD-Q scores (OR ¼ 1.256, 95% CI ¼ 1.176-1.343), weight increase (OR ¼ 1.014, 95% CI ¼ 1.003-1.025) and high alcohol consumption (OR ¼ 2.49, 95% CI ¼ 1. 16-5.36). Conclusion: Severe esophagitis is a rare finding in the Spanish population. Male gender, high GERD-Q score, weight increase and high alcohol consumption are main risk factors for its appearance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

et al. 2016

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“…In Eastern Asia, the lifestyle and dietary habits have changed towards a more Western style, and the prevalence of GERD is likely to have increased as a result. [4][5][6][7][8][9] However, limited data exist on the response to PPI therapy and the recurrence of GERD in East Asian countries, including Korea. [10][11][12][13] Patients with GERD have a decreased health-related quality of life (HRQoL).…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8][9] Obesity may be the important cause of discrepancy in the prevalence of GERD between Eastern and Western countries. 30 Obesity was associated with frequent GERD symptoms in a dosedependent manner.…”

mentioning

confidence: 99%

Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

Shin

Cheon

et al. 2015

J Neurogastroenterol Motil

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Background/AimsLimited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population. MethodsThis was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4 (or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline, end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12 months following treatment was carried out. ResultsCR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912; P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and worsened more during follow-up in patients with recurrence than in those without recurrence. ConclusionsWe should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.

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Prevention and Control of Dental Erosion: Gastroesophageal Reflux Disease Management

Patel

Brady

2015

Dental Erosion and Its Clinical Management

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Approximately 10-20 % of the general population suffers from gastroesophageal refl ux disease or GERD. GERD can manifest as esophageal and extraesophageal symptoms. GERD may damage the dental tissues, causing disorders such as dental erosion. According to studies, 24 % of patients with GERD have dental erosion, and 32 % of adults and 17 % of children with dental erosion have GERD. However, not all affected persons will have classic symptoms of GERD. Dentists may be the fi rst persons to diagnose GERD in these "silent refl uxers," particularly when observing unexplained tooth erosion. The cause of GERD is multifactorial, but the basic cause is incompetent antirefl ux barriers at the gastroesophageal junction. However, other causes have also been attributed to GERD which include decreased saliva production, diet, eating habits, medications, and obesity. Typical manifestations of GERD are heartburn, regurgitation, and dysphagia. Other symptoms have also been associated with GERD, and if any "alarm symptoms" are present, then further evaluation is required. The location of the erosive tooth wear in the dentition is specifi c to each etiologic factor. Refl uxed acid fi rst damages the palatal surface of the upper incisors then the other surfaces of the maxillary teeth. In chronic GERD, the labial or buccal surfaces are affected then the occlusal surfaces of maxillary and mandibular teeth. The diagnosis of GERD can be made clinically, physiologically, anatomically, or functionally depending on the testing modality. The mainstay management

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Gastroesophageal Reflux Disease Questionnaire (GerdQ) in real‐world practice: A national multicenter survey on 8065 patients

Cited by 63 publications

References 19 publications

Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

Prevention and Control of Dental Erosion: Gastroesophageal Reflux Disease Management

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