Gastroesophageal reflux disease combined with Oddi sphincter dysfunction: control of health-related quality of life in patients

Abstract

Background. Due to the need to assess the impact of comorbid pathology (GERD and Oddi sphincter dysfunction), it is not possible to use such well-known specific questionnaires as the GERD Health-Related Quality of Life Questionnaire, the Quality of Life in Reflux and Dyspepsia and others. The purpose: to study Health-Related Quality of Life (HRQoL) before and after treatment in patients with GERD, combined with dysfunction of the sphincter of Oddi, using Short Form Health Status Survey (SF-36) and the self-developed specific questionnaire. Materials and me­thods. 30 patients with comorbid diseases GERD and Oddi’s sphincter dysfunction were studied. SF-36 and the self-developed specific questionnaire were used. Results. The specific questionnaire for patients with gastoesophageal reflux disease combined with Sphincter of Oddi dysfunction was worked out. The evaluation of the questionnaire (patients comprehensiveness of questions, timesuming etc.) was explored. Using SF-36, it was significant improvement of HRQoL for all scales after treatment compared with initial data: physical functioning (PF, (77,1 ± 2,0) versus (71,4 ± 2,2)), role-physical functioning (RP, (52,1 ± 5,0) versus (30,6 ± 2,4)), bodily pain (BP, (65,8 ± 1,2) versus (48,7 ± 2,1)), social functioning (SF, (69,5 ± 2,0) versus (50,8 ± 2,1)), mental health (MH, (68,5 ± 2,1) versus (49,8 ± 1,8)), role emotional (RE, (65,2 ± 4,7) versus (35,8 ± 3,7)), vitality (VT, (63,3 ± 2,1) versus (43,2 ± 2,2)), general health (GH, (58,1 ± 2,4) versus (46,1 ± 1,7) points). All patients had decreased HRQoL due to comorbid GERD and sphincter dysfunction Oddi. Moderate or significant disorders of activity and rhythm of life due to these diseases was revealed, but after treatment there was an improvement in significant HRQoL in all patients, in addition to psycho-emotional perception of their diseases became more positive. Conclusions. All patients had decreased HRQoL due to comorbid GERD and sphincter dysfunction Oddi, and it improved after treatment in most of patients.

Autonomic dysfunction and psychosomatic changes in patients after cholecystectomy and gastroesophageal reflux disease

“…Патогенез розвитку гастроезофагеальної рефлюксної хвороби (ГЕРХ) на сьогодні пов'язують із функціональною недостатністю нижнього стравохідного сфінктера, причиною якої є низка факторів. Але на сьогодні є важливим розглядати проблему розвитку ГЕРХ у комплексному розумінні проблем клапанного апарату верхнього відділу шлунково-кишкового тракту [3], особливо у пацієнтів після ХЕ. При цьому ГЕРХ може призвести до симптоматичного навантаження пацієнта з поліморбідною патологією, а також значного зни-ження якості життя, особливо при формуванні ускладнень, таких як ерозивний езофагіт, стравохід Барретта, аденокарцинома стравоходу, збільшуючи витрати на лікування таких хворих [4].…”