Gastroesophageal Reflux Disease-Associated Chronic Cough: A Population-Based Analysis of Patient Presentations in the United States

Qureshi, Fahad; Asad, Hussein; Patel, Parth; Ramprasad, Aarya; Singh, Som; Sethi, Sanjay; Cheng, An‐Lin; Salzman, Gary

doi:10.7759/cureus.17512

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there is currently a lack of adequate evidence to support the use of empiric PPI therapy in patients who solely experience LPR symptoms (54). Several uncontrolled studies have indicated that treating chronic cough with antacids can lead to improvement (55). However, recent randomized controlled trial (56) has demonstrated no discernible distinctions between proton pump inhibitors (PPIs) and a placebo in terms of their effectiveness.…”

Section: Proton Pumps Inhibitors (Ppis)mentioning

confidence: 99%

Narrative review of relationship between chronic cough and laryngopharyngeal reflux

Hránková,

Balner,

Gubová

et al. 2024

Front. Med.

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) as a possible cause of chronic cough is known for decades. However, more than 75% of patients with extraoesophageal symptoms do not suffer from typical symptoms of GERD like pyrosis and regurgitations and have negative upper gastrointestinal endoscopy. For such a condition term laryngopharyngeal reflux (LPR) was introduced and is used for more than two decades. Since the comprehensive information on relationship between chronic cough and LPR is missing the aim of this paper is to summarize current knowledge based on review of published information during last 13 years. Laryngopharyngeal reflux is found in 20% of patients with chronic cough. The main and recognized diagnostic method for LPR is 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring, revealing reflux episodes irritating the upper and lower respiratory tract mucosa. The treatment of LPR should be initiated with dietary and lifestyle measures, followed by proton pump inhibitor (PPI) therapy and other measures. Despite progress, more research is needed for accurate diagnosis and targeted therapies. Key areas for exploration include biomarkers for diagnosis, the impact of non-acid reflux on symptom development, and the efficacy of new drugs. Further studies with a focused population, excluding other causes like asthma, and using new diagnostic criteria for LPR are essential. It’s crucial to consider LPR as a potential cause of unexplained chronic cough and to approach diagnosis and treatment with a multidisciplinary perspective.

show abstract

Section: Proton Pumps Inhibitors (Ppis)mentioning

confidence: 99%

Narrative review of relationship between chronic cough and laryngopharyngeal reflux

Hránková,

Balner,

Gubová

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Однако установление четкой причинно-следственной связи между ГЭРБ и сопутствующими респираторными заболеваниями является сложной задачей в повседневной практике [23]. Помимо изжоги и регургитации существуют внепищеводные проявления ГЭРБ, которые включают БА, хроническую обструктивную болезнь лёгких, хронический кашель [24,25,26], ЛФР, ларингит и синусит, дентальные эрозии [25,27,28,29]. Эти атипичные проявления ГЭРБ, являясь объектом пристального внимания ученых и клиницистов, часто ставят диагностические и терапевтические проблемы и могут потребовать мультидисциплинарного подхода [20,30].…”

Section: распространенность гастроэзофагеальной рефлюксной болезни и ...unclassified

Syntropy of bronchial asthma and gastroesophageal reflux disease: pathogenetic features and possibilities of minimally invasive diagnostics at the outpatient stage

Горбань

Kovrigina

Gorban

et al. 2023

jour

View full text Add to dashboard Cite

The review highlights the prevalence, pathogenesis and clinical manifestations of bronchial asthma (BA), comorbid with gastroesophageal reflux disease (GERD). Difficulties in diagnosing triggers of extraesophageal symptoms were noted. Based on a large number of clinical studies, the review assesses the possibilities of minimally invasive methods for detecting biomarkers of gastroesophageal reflux (GER) and duodenogastroesophageal reflux (DGER) in the oral fluid. With syntropy of GERD and BA, a significant role and relationship between the parameters of respiratory oxidative inflammation and impaired functions of external respiration was noted. To confirm the reflux origin of extraesophageal respiratory symptoms, it is important to use minimally invasive methods for detecting bilirubin and pepsin in the oral fluid, and to assess the activity of respiratory stress, the determination of its substrates in the blood. Further studies aimed at determining the normative concentrations of DGER substrates in the oral fluid and markers of oxidative respiratory inflammation in the blood will help improve the diagnosis and treatment of BA and GERD syntropy in outpatient practice.

show abstract

“…Патофізіологічна роль Герх у прояві хронічного кашлю пов'язана з двома переважаючими механізмами: блукаючим стравохідно-трахеобронхіальним рефлюксом і мікроаспірацією вмісту шлунка [22].…”

Section: результати дослідженняunclassified

Феномен Взаємного Обтяження Соvіd-19 Та Гастроезофагеальної Рефлюксної Хвороби З Ларингофарингеальними Проявами

2022

UMJ

View full text Add to dashboard Cite

Анотація. У статті проаналізовано останні наукові дані стосовно механізму кашлю як атипового прояву гастроезофагеальної рефлюксної хвороби та його взаємозв'язок з кашлем при COVID-19. Зроблено висновок, що поєднання у пацієнта гастроезофагеальної рефлюксної хвороби, особливо атипової ларингофарингеальної форми, з COVID-19 викликає взаємо обтяжувальний ефект і потребує виваженого підходу до лікування. При відсутності ерозивних уражень стравоходу доцільно застосовувати препарати альгінової кислоти або антациди, а також їх комбінації в якості 1-ї лінії лікування хворих на етапі первинної ланки. Ключові слова: COVID-19, гастроезофагеальна рефлюксна хвороба, альгінати.

show abstract

Gastroesophageal Reflux Disease-Associated Chronic Cough: A Population-Based Analysis of Patient Presentations in the United States

Cited by 3 publications

References 15 publications

Narrative review of relationship between chronic cough and laryngopharyngeal reflux

Narrative review of relationship between chronic cough and laryngopharyngeal reflux

Syntropy of bronchial asthma and gastroesophageal reflux disease: pathogenetic features and possibilities of minimally invasive diagnostics at the outpatient stage

Феномен Взаємного Обтяження Соvіd-19 Та Гастроезофагеальної Рефлюксної Хвороби З Ларингофарингеальними Проявами

Contact Info

Product

Resources

About