Gastroesophageal reflux disease and odds of head and neck squamous cell carcinoma in <scp>N</scp>orth <scp>C</scp>arolina

Busch, Evan L.; Zevallos, José P.; Olshan, Andrew F.

doi:10.1002/lary.25716

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…The relationship between GERD and non‐oropharyngeal HNSCC is mixed with many earlier studies suggesting an association with hypopharynx or larynx cancer, but recent studies have not supported these findings 23‐26 . Our study is the first study of PLWH to examine GERD, in which we observed an association of GERD with non‐oropharyngeal HNSCC.…”

Section: Discussioncontrasting

confidence: 66%

Incidence and survival for oropharynx and non‐oropharynx head and neck cancers among veterans living with HIV

et al. 2020

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Section: Discussioncontrasting

confidence: 66%

Incidence and survival for oropharynx and non‐oropharynx head and neck cancers among veterans living with HIV

et al. 2020

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“…Several previous studies have tested for the association between GERD and laryngeal squamous cell carcinoma (LSCC), but the results have been inconsistent 6‐13 . Most previous studies have been limited by size, study design, or insufficient control for important potential confounders (eg, tobacco use and alcohol consumption 14‐16 ), limiting the strength of the inference 17‐19 .…”

Section: Introductionmentioning

confidence: 99%

“…Several previous studies have tested for the association between GERD and laryngeal squamous cell carcinoma (LSCC), but the results have been inconsistent. [6][7][8][9][10][11][12][13] Most previous studies have been limited by size, study design, or insufficient control for important potential confounders (eg, tobacco use and alcohol consumption [14][15][16] ), limiting the strength of the inference. [17][18][19] A recent meta-analysis summarizing 15 case-control studies revealed a 2.37-fold higher risk of LSCC among individuals who have GERD, 13 while other studies have suggested that this association is driven largely by residual confounding due to unmeasured variables such as tobacco use and alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma in the NIH‐AARP Diet and Health Study cohort

Wang

Freedman

Katki

et al. 2021

Cancer

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Background Prior studies have suggested that gastroesophageal reflux disease (GERD) may be associated with risk of squamous cancers of the larynx and esophagus; however, most of these studies have had methodological limitations or insufficient control for potential confounders. Methods We prospectively examined the association between GERD and esophageal adenocarcinoma (EADC), esophageal squamous cell carcinoma (ESCC), and laryngeal squamous cell carcinoma (LSCC) in 490,605 participants of the NIH‐AARP Diet and Health Study cohort who were 50‐71 years of age at baseline. Exposure to risk factors were obtained from the baseline questionnaire. GERD diagnosis was extracted among eligible participants via linkage to Medicare diagnoses codes and then multiply imputed for non–Medicare‐eligible participants. Hazard ratios (HRs) and 95% CIs of GERD were computed using Cox regression. Results From 1995 to 2011, we accrued 931 cases of EADC, 876 cases of LSCC, and 301 cases of ESCC in this cohort and estimated multivariable‐adjusted HRs of 2.23 (95% CI, 1.72‐2.90), 1.91 (95% CI, 1.24‐2.94), and 1.99 (95% CI, 1.39‐2.84) for EADC, LSCC, and ESCC, respectively. The associations were independent of sex, smoking status, alcohol intake, and follow‐up time periods. We estimated that among the general population in the United States, 22.04% of people aged 50‐71 years suffered from GERD. Using risk factor distributions for the United States from national survey data, 16.92% of LSCC cases and 17.32% of ESCC cases among individuals aged 50‐71 years were estimated to be associated with GERD. Conclusion GERD is a common gastrointestinal disorder, but future prospective studies are needed to replicate our findings. If replicated, they may inform clinical surveillance of GERD patients and suggest new avenues for prevention of these malignancies.

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“…Some studies have shown that non-acidic reflux promotes the development of laryngeal carcinoma. [22][23][24] Thus, the relationship between LPRD and laryngeal carcinoma requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

Gastric H+/K+-ATPase Expression in Normal Laryngeal Tissue and Laryngeal Carcinoma

Bao

Jiang

et al. 2020

OTT

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Background Several studies have suggested that laryngopharyngeal reflux disease (LPRD) or gastroesophageal reflux disease (GERD) is an independent risk factor for laryngeal carcinoma. However, it remains unclear whether either condition affects the level of H + /K + -ATPase expression in laryngeal carcinoma. Materials and Methods Immunohistochemistry, real-time RT-PCR, and Western blotting were used to explore the distributions of proton pump (H + /K + -ATPase) α- and β-subunits in normal laryngeal tissue and laryngeal carcinoma. Results Messenger RNAs encoding both the α- and β-subunits were found in the normal epiglottic, ventricular fold, vocal fold, and arytenoid mucosae, as well as epiglottic cartilage. The distributions and expression levels of H+/K+-ATPase α-subunits in various laryngeal subregions did not significantly differ in IHC, RT-PCR, or Western blotting. However, Western blotting revealed a significant difference between the expression level of the β-subunit protein in the epiglottic cartilage and the levels in other sites. The expression levels of both subunits were significantly higher in carcinomatous than in paracarcinomatous tissue and normal laryngeal tissue. The mean follow-up duration was 66.2 months (range, 17–162 months). In all, 4 patients died during follow-up, 4 were lost to follow-up, and 22 were alive and free of disease at the end of follow-up. Two patients developed lung metastases and six developed disease recurrences (at 2, 8, 14, 16, 36, and 41 months). The 3- and 5-year overall survival (OS) rates were 93.0% and 77.0%, respectively. Univariate analyses showed that the 5-year OSs were significantly associated with the T, N, and clinical stages but not with age, alcohol use, pathological differentiation, or the expression levels of the α- or β-subunits (as revealed by IHC, RT-PCR, or Western blotting). However, in multivariate regression analyses, the 5-year OSs were not significantly associated with any clinicopathological factor or the expression levels of either subunit. Conclusion H + /K + -ATPase is expressed in the normal larynx, including in the epiglottic cartilage and the mucosae of the epiglottis, ventricular fold, and arytenoid vocal fold. The expression levels of the H + /K + -ATPase α- and β-subunits in laryngeal carcinomas were higher than in normal laryngeal tissues.

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Gastroesophageal reflux disease and odds of head and neck squamous cell carcinoma in North Carolina

Abstract: 3b. Laryngoscope, 126:1091-1096, 2016.

Cited by 8 publications

References 21 publications

Incidence and survival for oropharynx and non‐oropharynx head and neck cancers among veterans living with HIV

Incidence and survival for oropharynx and non‐oropharynx head and neck cancers among veterans living with HIV

Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma in the NIH‐AARP Diet and Health Study cohort

<p>Gastric H<sup>+</sup>/K<sup>+</sup>-ATPase Expression in Normal Laryngeal Tissue and Laryngeal Carcinoma</p>

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