Gastroesophageal reflux disease and head and neck cancers: A systematic review and meta-analysis

Eells, Annica C.; Mackintosh, Chris; Marks, Lisa; Marino, Michael J.

doi:10.1016/j.amjoto.2020.102653

Cited by 14 publications

(11 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, H. pylori is present in laryngeal mucosa [ 20 ] and has the potential to damage epithelial and mucosal barriers, and that the subsequent inflammatory process can lead to chronic harm and epithelial cell proliferation resulting in laryngeal pathology [ 21 ]. Although the relationship between H. pylori and gastroesophageal reflux disease is not conclusive [ 22 ], the presence of GERD is associated with an increased risk of developing laryngeal cancer [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

et al. 2021

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan.

show abstract

Section: Introductionmentioning

confidence: 99%

Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…LPR is reportedly associated with laryngeal cancer [32][33][34]. Pepsin, a key non-acid component of LPR [35,36], is the first protease that food proteins come across in the digestive tract.…”

Section: Discussionmentioning

confidence: 99%

Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia

Zhang

Zhou

et al. 2022

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose The mechanism underlying malignant transformation of vocal fold leukoplakia (VFL) and the precise role of the expression of pepsin in VFL remain unclear. This study aimed to investigate the effects of acidified pepsin on VFL epithelial cell growth and migration, and also identify pertinent molecular mechanisms. Methods Immunochemistry and Western blotting were performed to measure glucose transporter type 1 (GLUT1), monocarboxylate transporters 4 (MCT4), and Hexokinase-II (HK-II) expressions. Cell viability, cell cycle, apoptosis, and migration were investigated by CCK-8 assay, flow cytometry and Transwell chamber assay, respectively. Glycolysis-related contents were determined using the corresponding kits. Mitochondrial HK-II was photographed under a confocal microscope using Mito-Tracker Red. Results It was found: the expression of pepsin and proportion of pepsin+ cells in VFL increased with the increased dysplasia grade; acidified pepsin enhanced cell growth and migration capabilities of VFL epithelial cells, reduced mitochondrial respiratory chain complex I activity and oxidative phosphorylation, and enhanced aerobic glycolysis and GLUT1 expression in VFL epithelial cells; along with the transfection of GLUT1 overexpression plasmid, 18FFDG uptake, lactate secretion and growth and migration capabilities of VFL epithelial cell were increased; this effect was partially blocked by the glycolysis inhibitor 2-deoxy-glucose; acidified pepsin increased the expression of HK-II and enhanced its distribution in mitochondria of VFL epithelial cells. Conclusion It was concluded that acidified pepsin enhances VFL epithelial cell growth and migration abilities by reducing mitochondrial respiratory complex I activity and promoting metabolic reprogramming from oxidative phosphorylation to aerobic glycolysis.

show abstract

“…Another study mentioned an increased risk of mouth and pharyngeal cancer with RR 9.7, falling to the risk of the general population after 5 years of GFD [ 21 ]. Our patient had diagnoses of CD and gastroesophageal reflux disease, a risk factor for oropharyngeal cancer [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Malignant complications of celiac disease: a case series and review of the literature

et al. 2022

View full text Add to dashboard Cite

Background Celiac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Diagnosis is based on evaluating specific autoantibodies and histopathologic findings of duodenal biopsy specimens. The only therapy for celiac disease is a gluten-free diet. Celiac disease can be complicated by malnutrition, other autoimmune diseases, refractoriness to treatment, and gastrointestinal tumors. This article presents seven cases of malignancies in patients with celiac disease. Its objective is to raise awareness of the malignant complications of celiac disease, leading to earlier diagnosis and improved outcomes. Case presentation Seven cases of malignant complications of celiac disease occurred among 190 patients followed at the Department of Internal Medicine and Gastroenterology, University Hospital Brno from 2014 to 2021. We describe these cases and the presentation, diagnostic process, course, management, and outcomes for each, along with proposed potential risk factors of malignant complications. There was one Caucasian man who was 70 years old and six Caucasian women who were 36, 46, 48, 55, 73, and 82 years old in our cohort. Of the seven cases of malignancies in our cohort, four patients were diagnosed with small bowel adenocarcinoma, one with diffuse large B-cell lymphoma, one with carcinoma of the tongue, and one with colorectal carcinoma. Conclusions Malignancies occurred in 3.7% of patients followed up for celiac disease. Awareness of the malignant complications of celiac disease, risk factors, presentation, and disease course could lead to earlier diagnosis and improved outcomes.

show abstract

Gastroesophageal reflux disease and head and neck cancers: A systematic review and meta-analysis

Cited by 14 publications

References 27 publications

Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia

Malignant complications of celiac disease: a case series and review of the literature

Contact Info

Product

Resources

About