Gastroesophageal reflux and obstructive sleep apnea in childhood

Noronha, Alessandra Caland; Bruin, Veralice Meireles Sales de; Souza, Miguel Angelo N.; Freitas, Marcos Rabelo de; Araújo, Roberta de Paula; Mota, Rosa Maria Salani; Bruin, Pedro Felipe Carvalhedo de

doi:10.1016/j.ijporl.2008.11.002

Cited by 49 publications

(16 citation statements)

References 28 publications

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“…Residual OSA cases had a significantly lower mean intraluminal esophageal pH and a significantly lower minimal value of pH during sleep. Similar to a study by Noronha et al no correlation occurred between OSA severity and GER standard parameters [15]. Of all recorded GER parameters, only minimal values of pH during night sleep were associated with respiratory indices.…”

Section: Discussionsupporting

confidence: 87%

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Obstructive hypopnea and gastroesophageal reflux as factors associated with residual obstructive sleep apnea syndrome

Wasilewska

Kaczmarski

Dębkowska

2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionsupporting

confidence: 87%

“…In previous studies acidification of the distal esophagus was also suggested in the mechanism of OSA in children and adults and in the mechanism of residual OSA in children under 2 years old [13][14][15][16]. However, the role of gastroesophageal reflux in residual OSA among children over 2 years of age is unclear.…”

mentioning

confidence: 99%

Obstructive hypopnea and gastroesophageal reflux as factors associated with residual obstructive sleep apnea syndrome

Wasilewska

Kaczmarski

Dębkowska

2011

International Journal of Pediatric Otorhinolaryngology

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“…In children with adenotonsillar hypertrophy and obstructive sleep apnea syndrome, there are both GERD and prolonged inspiratory effort due to airway obstruction. Despite most of such children having pathological reflux, those with the worst apnea indexes tended to have less esophageal acid exposure (20). Had such children naturally trained their diaphragms, therefore, compensating a bit for their antireflux barrier weaknesses?…”

mentioning

confidence: 99%

Inspiratory muscle training improves antireflux barrier in GERD patients

Souza

Lima

Martins

et al. 2013

American Journal of Physiology-Gastrointestinal and Liver Physi

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Nobre e Souza MÂ, Lima MJ, Martins GB, Nobre RA, Souza MH, de Oliveira RB, dos Santos AA. Inspiratory muscle training improves antireflux barrier in GERD patients. Am J Physiol Gastrointest Liver Physiol 305: G862-G867, 2013. First published October 10, 2013 doi:10.1152/ajpgi.00054.2013.-The crural diaphragm (CD) is an essential component of the esophagogastric junction (EGJ), and inspiratory exercises may modify its function. This study's goal is to verify if inspiratory muscle training (IMT) improves EGJ motility and gastroesophageal reflux (GER). Twelve GER disease [GERD; 7 males, 20 -47 yr, 9 esophagitis, and 3 nonerosive reflex disease (NERD)] and 7 healthy volunteers (3 males, 20 -41 yr) performed esophageal pH monitoring, manometry, and heart rate variability (HRV) studies. A 6-cm sleeve catheter measured average EGJ pressure during resting, peak inspiratory EGJ pressures during sinus arrhythmia maneuver (SAM) and inhalations under 17-, 35-, and 70-cmH2O loads (TH maneuvers), and along 1 h after a meal. GERD patients entered a 5-days-a-week IMT program. One author scored heartburn and regurgitation before and after IMT. IMT increased average EGJ pressure (19.7 Ϯ 2.4 vs. 29.5 Ϯ 2.1 mmHg; P Ͻ 0.001) and inspiratory EGJ pressure during SAM (89.6 Ϯ 7.6 vs. 125.6 Ϯ 13.3 mmHg; P ϭ 0.001) and during TH maneuvers. The EGJ-pressure gain across 35-and 70-cmH2O loads was lower for GERD volunteers. The number and cumulative duration of the transient lower esophageal sphincter relaxations decreased after IMT. Proximal progression of GER decreased after IMT but not the distal acid exposure. Low-frequency power increased after IMT and the higher its increment the lower the increment of supine acid exposure. IMT decreased heartburn and regurgitation scores. In conclusion, IMT improved EGJ pressure, reduced GER proximal progression, and reduced GERD symptoms. Some GERD patients have a CD failure, and IMT may prove beneficial as a GERD add-on treatment. crural diaphragm; GERD; lower esophageal sphincter; muscle training

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“…Increased symptoms of anxiety, attention deficits and learning problems were also noted in the overall sample. In another study, subjects with mild OSAS tended to have significantly more behavioral, emotional and bedtime problems than subjects with severe OSAS (Noronha et al 2009). Gozal and Pope (2001) used parental questionnaires to evaluate the prevalence of sleep-disordered breathing in children with academic and behavioral problems.…”

mentioning

confidence: 91%

Influence of obstructive sleep apnea syndrome on cognition development in children

Ding

Liu

Zhang

2010

Biological Rhythm Research

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Obstructive sleep apnea syndrome (OSAS) was first described more than a century ago; however, OSAS in children was first described in 1976. OSAS is a common problem in children as in adults, with a prevalence of 1-3%. OSAS is becoming a substantial health risk in children and the under-diagnosed condition may lead to substantial morbidity if left untreated. Childhood OSAS could be associated with cognitive development, but the impact of OSAS on cognitive learning is unclear; it could be associated with cognitive and functional deficits. Recent evidence suggests the possibility of sustained cognitive impairment in children with OSAS. There is little published on this subject, and the aim of this review is to provide a synthesis of the current literature addressing the effects of OSAS on cognitive development in children.

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Gastroesophageal reflux and obstructive sleep apnea in childhood

Cited by 49 publications

References 28 publications

Obstructive hypopnea and gastroesophageal reflux as factors associated with residual obstructive sleep apnea syndrome

Obstructive hypopnea and gastroesophageal reflux as factors associated with residual obstructive sleep apnea syndrome

Inspiratory muscle training improves antireflux barrier in GERD patients

Influence of obstructive sleep apnea syndrome on cognition development in children

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