Gastroesophageal reflux and laryngeal dysfunction in a dog

Lux, Cassie N.; Archer, Todd; Lunsford, Kari V.

doi:10.2460/javma.240.9.1100

Cited by 26 publications

(40 citation statements)

References 16 publications

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“…Perhaps not surprisingly, these results suggest that clinical signs such as lip smacking are nonspecific. Nevertheless, we deliberately included patients presenting with a wider range of clinical signs than have either been reported in dogs, or have been associated with GERD in people, such as chronic upper respiratory problems, in order not to overlook potential reflux patients.…”

Section: Discussionmentioning

confidence: 99%

“…Mild upper respiratory signs (eg, cough, laryngitis) also were noted among repeated swallowing motions, lip smacking, belching, and retching in 2 dogs. According to some authors, development of recurrent cough without obvious involvement of the respiratory tract can be the only sign of GER in dogs . Microaspirations of gastric contents are discussed as a cause of chronic respiratory disease in humans .…”

Section: Discussionmentioning

confidence: 99%

“…Although GER also has been implicated as an underlying cause of presumed esophagitis in dogs, it currently is unclear whether GER represents a clinically relevant problem, and, if so, what its clinical signs would be. The diagnoses of all reported cases of esophagitis secondary to presumed GER in small animals have been made based on a combination of presumably typical historical and clinical signs, as well as radiographic, endoscopic, or histopathological findings without the actual demonstration of pathologic esophageal pH . Wireless intraesophageal pH monitoring has not been performed in dogs so far, and little is known about the physiologic esophageal canine pH range or how physiologic reflux episodes are characterized.…”

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confidence: 99%

“…In veterinary medicine, this device has been recently used for prolonged measurement of intragastric pH in healthy dogs. 6 Although GER also has been implicated as an underlying cause of presumed esophagitis in dogs, [7][8][9][10][11][12] it currently is unclear whether GER represents a clinically relevant problem, and, if so, what its clinical signs would be. The diagnoses of all reported cases of esophagitis secondary to presumed GER in small animals have been made based on a combination of presumably typical historical and clinical signs, as well as radiographic, endoscopic, or histopathological findings without the actual demonstration of pathologic esophageal pH.…”

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confidence: 99%

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Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Kook

Kempf

Ruetten

et al. 2014

Veterinary Internal Medicne

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BackgroundAlthough gastroesophageal reflux (GER) often is assumed to be causative for upper gastrointestinal and respiratory signs in dogs, no attempts have been made to verify this assumption.ObjectivesTo monitor esophageal pH with the Bravo pH system in healthy dogs and client‐owned dogs displaying signs commonly attributed to GER.AnimalsSeven healthy and 22 client‐owned dogs.MethodsAfter routine esophagogastroduodenoscopy, radiotelemetric pH capsules were placed in distal esophagus for continuous pH recording. Reflux was defined as single pH measurement <4. At discharge, owners were instructed to press individually predefined clinical sign‐buttons on the receiver whenever indicated. Results between groups were compared using Mann–Whitney U‐test.ResultsThe median (range) number of refluxes in client‐owned and healthy dogs, respectively, was 17 (1–205) and 10 (1–65), the number of refluxes >5 minutes in duration was 1 (0–14), and 1 (0–4), duration of longest reflux (min) was 10 (0–65) and 8 (0–27), and fractional time pH <4 (%) was 0.76% (0.01–6.28), and 0.3% (0–3.1). No differences were found between groups. The median of 7 (1–35) clinical sign‐button pushes were recorded in 21 dogs. Median of 12.5% (2.8% [1/35]–50% [2/4]) reflux‐positive clinical sign‐button pushes was found in 10 dogs with reflux‐positive pushes. Five (22.7%) dogs had increased esophageal acid exposure, and mild esophagitis was noted in 1 dog.Conclusion and Clinical ImportanceDespite evidence of increased GER in some dogs, the clinical sign‐reflux association remained poor. Future investigation should focus on dogs with esophagitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Kook

Kempf

Ruetten

et al. 2014

Veterinary Internal Medicne

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“…H. felis has been associated with active chronic gastritis and H. bizzozeronnii with duodenal and gastric ulcers [22]. Naturally occurring Helicobacter, can also colonize the intestinal crypts leading to lymphocytic enteritis and canine inflammatory bowel disease, often associated with diarrhea, gastro esophageal reflux and vomiting [23, 24]. There is documented evidence that domestic animals are a source of infection for human beings [22].…”

Section: Introductionmentioning

confidence: 99%

Preclinical evaluation of anti-Helicobacter spp. activity of Hippocratea celastroides Kunth and its acute and sub-acute toxicity

García-Alonso¹,

Monroy-Noyola

Contreras-Arellano

et al. 2016

BMC Complement Altern Med

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Background Hippocratea celastroides Kunth, commonly known as “cancerina”, is used in Mexican Traditional Medicine for the treatment of gastric and intestinal infections, systemic and skin inflammation, injuries and gastritis. The aim of this research was to assess the anti-Helicobacter pylori activities of hydro-ethanolic root-bark extracts from Hippocratea celastroides Kunth in naturally infected dogs, after testing their acute and subacute toxicities in mice.MethodsTo determine in vivo acute toxicity, a hydro-ethanolic extract was obtained and administered orally in female and male Balb-C mice, at doses ranging from 2000 to 5000 mg/kg. For the subacute study, a hydro-ethanolic extract was given to male and female Balb-C mice at doses ranging from 200 to 2000 mg/kg body weight. The animals were observed daily over a period of 42 days for signs of toxicity. In the pre-clinical anti-Helicobacter spp. assay, 60 dogs were included. Eighteen and 19 dogs for the experimental and control groups respectively, concluded the study. The experimental treatment consisted of H. celastroides hydro-ethanolic extract and the control treatment of amoxicillin-clarithromycin-omeprazole.ResultsOral LD50 (lethal dose 50) values for hydro-ethanolic extract were indeterminable at the highest tested doses. Under the subacute administration, neither mortality nor any sign of toxicity were observed when the hydro-ethanolic extract was administered. There were no significant alterations in biochemical parameters. The prevalence of Helicobacter spp. infection in dogs was 97.1 % for the experimental group and 100 % for the control group. Effectiveness was of 33.3 and 55 % in the experimental and control group respectively. The oral administration of H. celastroides was well-tolerated and safe.ConclusionThe root-bark of H. celastroides produced no signs of toxicity, and manifested pharmacological activity that indicated the possibility of an alternative treatment for H. pylori infection. Effectiveness is still low so it is necessary to continue research.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1412-6) contains supplementary material, which is available to authorized users.

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Coughing and Hemoptysis

Heffner

2018

Textbook of Small Animal Emergency Medicine

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Gastroesophageal reflux and laryngeal dysfunction in a dog

Cited by 26 publications

References 16 publications

Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Wireless Ambulatory Esophageal pH Monitoring in Dogs with Clinical Signs Interpreted as Gastroesophageal Reflux

Preclinical evaluation of anti-Helicobacter spp. activity of Hippocratea celastroides Kunth and its acute and sub-acute toxicity

Coughing and Hemoptysis

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