Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a radiomic model to predict tumor grade

Chiti, Giuditta; Grazzini, Giulia; Flammia, Federica; Matteuzzi, Benedetta; Tortoli, Paolo; Bettarini, Silvia; Pasqualini, Elisa; Granata, Vincenza; Busoni, S.; Messserini, Luca; Pradella, Silvia; Massi, Daniela; Miele, Vittorio

doi:10.1007/s11547-022-01529-x

Cited by 37 publications

(28 citation statements)

References 44 publications

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“…Liver loco-regional treatments, like trans-arterial chemoembolization (TACE) or radio embolization (TARE), have been employed for the treatment of unresectable intrahepatic metastasis (IM) with benefit on overall survival. For large or multinodular tumours locoregional therapies are preferred if the liver function is preserved [65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80]. Thermal ablation techniques including RFA, MWA and CRYO, are used for treatment of primary and secondary liver tumors.…”

Section: Discussionmentioning

confidence: 99%

Percutanous Electrochemotherapy (ECT) in Primary and Secondary Liver Malignancies: A Systematic Review

Granata

Fusco²,

D'Alessio³

et al. 2023

Diagnostics

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The aim of the study was to analyse papers describing the use of Electrochemotherapy (ECT) in local treatment of primary and secondary liver tumours located at different sites and with different histologies. Other Local Ablative Therapies (LAT) are also discussed. Analyses of these papers demonstrate that ECT use is safe and effective in lesions of large size, independently of the histology of the treated lesions. ECT performed better than other thermal ablation techniques in lesions > 6 cm in size and can be safely used to treat lesions distant, close, or adjacent to vital structures. ECT spares vessel and bile ducts, is repeatable, and can be performed between chemotherapeutic cycles. ECT can fill the gap in local ablative therapies due to being lesions too large or localized in highly challenging anatomical sites.

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Section: Discussionmentioning

confidence: 99%

Percutanous Electrochemotherapy (ECT) in Primary and Secondary Liver Malignancies: A Systematic Review

Granata

Fusco²,

D'Alessio³

et al. 2023

Diagnostics

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“…A definition for bile leak was standardized by the ISGLS [ 165 ]. The leakage may be due to an incompetent bile-digestive anastomosis or a bile ducts damage during the surgical procedure [ 166 , 167 , 168 , 169 , 170 , 171 ]. At US or CT examination, bile leaks may appear as a non-specific collection near the resection margins [ 165 ].…”

Section: Non Anatomic Liver Resectionmentioning

confidence: 99%

“…At US or CT examination, bile leaks may appear as a non-specific collection near the resection margins [ 165 ]. MRI with gadolinium- based hepatobiliary contrast agent (EOB-MRI) allows for proper site detection so as to classify the leakage sub-type ( Figure 7 ) [ 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 ]. On EOB-phase, bile leak is detected as an active overflow of contrast agent outside the biliary tree and inside the fluid collection [ 35 ].…”

Section: Non Anatomic Liver Resectionmentioning

confidence: 99%

Imaging Features of Main Hepatic Resections: The Radiologist Challenging

Cutolo

Fusco

Simonetti

et al. 2023

JPM

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Liver resection is still the most effective treatment of primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), and of metastatic disease, such as colorectal liver metastases. The type of liver resection (anatomic versus non anatomic resection) depends on different features, mainly on the type of malignancy (primary liver neoplasm versus metastatic lesion), size of tumor, its relation with blood and biliary vessels, and the volume of future liver remnant (FLT). Imaging plays a critical role in postoperative assessment, offering the possibility to recognize normal postoperative findings and potential complications. Ultrasonography (US) is the first-line diagnostic tool to use in post-surgical phase. However, computed tomography (CT), due to its comprehensive assessment, allows for a more accurate evaluation and more normal findings than the possible postoperative complications. Magnetic resonance imaging (MRI) with cholangiopancreatography (MRCP) and/or hepatospecific contrast agents remains the best tool for bile duct injuries diagnosis and for ischemic cholangitis evaluation. Consequently, radiologists should be familiar with the surgical approaches for a better comprehension of normal postoperative findings and of postoperative complications.

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“…Most primary pancreatic cancers are pancreatic ductal adenocarcinomas (PDACs); only a small proportion are pancreatic neuroendocrine tumors [46][47][48][49][50][51][52][53] and, even rarer, malignancies [54][55][56][57][58][59]. PDACs normally rise through a process that involves several stages, from pancreatic intraepithelial neoplasia (PanIN) [60].…”

Section: Introductionmentioning

confidence: 99%

Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence

Granata

Fusco

Setola

et al. 2023

Cancers

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Pancreatic cancer (PC) is one of the deadliest cancers, and it is responsible for a number of deaths almost equal to its incidence. The high mortality rate is correlated with several explanations; the main one is the late disease stage at which the majority of patients are diagnosed. Since surgical resection has been recognised as the only curative treatment, a PC diagnosis at the initial stage is believed the main tool to improve survival. Therefore, patient stratification according to familial and genetic risk and the creation of screening protocol by using minimally invasive diagnostic tools would be appropriate. Pancreatic cystic neoplasms (PCNs) are subsets of lesions which deserve special management to avoid overtreatment. The current PC screening programs are based on the annual employment of magnetic resonance imaging with cholangiopancreatography sequences (MR/MRCP) and/or endoscopic ultrasonography (EUS). For patients unfit for MRI, computed tomography (CT) could be proposed, although CT results in lower detection rates, compared to MRI, for small lesions. The actual major limit is the incapacity to detect and characterize the pancreatic intraepithelial neoplasia (PanIN) by EUS and MR/MRCP. The possibility of utilizing artificial intelligence models to evaluate higher-risk patients could favour the diagnosis of these entities, although more data are needed to support the real utility of these applications in the field of screening. For these motives, it would be appropriate to realize screening programs in research settings.

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Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a radiomic model to predict tumor grade

Cited by 37 publications

References 44 publications

Percutanous Electrochemotherapy (ECT) in Primary and Secondary Liver Malignancies: A Systematic Review

Percutanous Electrochemotherapy (ECT) in Primary and Secondary Liver Malignancies: A Systematic Review

Imaging Features of Main Hepatic Resections: The Radiologist Challenging

Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence

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