Gastroduodenal regulation of common duct bile flow in the dog

Mochinaga, Nobuo; Sarna, Sushil K.; Condon, Robert E.; Dodds, Wylie J.; Matsumoto, Teiji

doi:10.1016/0016-5085(88)90251-x

Cited by 27 publications

(17 citation statements)

References 12 publications

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“…This strengthens the hypothesis that the in terdigestive gallbladder dynamics might be mediated through local pylorocholecystic re flexes [41], and, furthermore, the cyclic pat terns of bile flow is altered when phase III activity starts ectopically in the jejunum [42] and finally another point of view might be that the cyclic gallbladder emptying is under the influence of other 'noncholecystokinin' peptides [43].…”

Section: Discussionsupporting

confidence: 59%

Cholecystokinin, Secretin, Pancreatic Polypeptide in Relation to Gallbladder Dynamics and Gastrointestinal Interdigestive Motility

Qvist

Oster-Jørgensen²,

Rasmussen³

et al. 1990

Digestion

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Using a combined technique of hepatobiliary scintigraphy and gastrointestinal motility recordings, the changes in blood concentrations of cholecystokinin (CCK), secretin and pancreatic polypeptide (PP) were studied in relation to gastrointestinal motility and gallbladder dynamics in the interdigestive state in 7 healthy male volunteers. No changes in CCK concentration were found in relation to the migrating motor complex (MMC). In 3 subjects a slightly but insignificant elevated secretin level was seen during phase I of the MMC, otherwise no changes were observed. More pronounced fluctuations in PP appeared with significantly higher values during phase III compared to phase II. Values of concentrations of CCK, secretin and PP in periods with gallbladder filling were not significantly different from the values in periods of emptying.

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Section: Discussionsupporting

confidence: 59%

Cholecystokinin, Secretin, Pancreatic Polypeptide in Relation to Gallbladder Dynamics and Gastrointestinal Interdigestive Motility

Qvist

Oster-Jørgensen²,

Rasmussen³

et al. 1990

Digestion

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“…The SO contractions are most powerful and frequent during this phase. Because of the similarity of motility in the duodenum and SO during phase III, some authors have considered that the SO did not have independent motility 42. However, the fact that the SO continues to contract during the quiescence of duodenal phase I supports the independent nature of SO motility.…”

Section: Cyclic Motility Of the Sphincter Of Oddimentioning

confidence: 99%

“…The mechanism is as follows: the activity front or phase III carries the food residue, secretions, and desquamated cells and empties them into the colon. During late phase II and phase III of the duodenal MMC, gallbladder tone increases, contractions occur, and bile flows into the duodenum 42,50. Among regular strong contractions of the duodenum and SO during phase III, there exist brief periods of quiescence when the SO relaxes, allowing bile flow into the duodenum 42.…”

Section: Cyclic Motility Of the Sphincter Of Oddimentioning

confidence: 99%

Cyclic motility of the sphincter of Oddi

Yokohata

Tanaka

2000

Journal of Hepato-Biliary-Pancreatic Surgery

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The sphincter of Oddi has a cyclic motility that is closely associated with the duodenal migrating motor complex during fasting. This close association affects the bile flow mechanism and may play several roles in keeping the intestine clean and maintaining the migrating motor complex. The cyclic motility of the sphincter of Oddi changes after surgery and abnormal motility causes biliary dyskinesia. In this article, the gastrointestinal migrating motor complex and cyclic motility of the sphincter of Oddi are reviewed for better understanding of biliary and gastrointestinal physiology and the relationship between the two phenomena.

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“…Because the contractions within the stomach do not "migrate" from the stomach to the small intestine, the activity is sometimes called cyclic motor activity (CMA) [26] . Similar cyclic contractile activity also occurs within the gallbladder [27,28] and within the lower esophageal sphincter [24] .…”

Section: Migrating Motor Complexmentioning

confidence: 66%

Effects of radiation upon gastrointestinal motility

Otterson¹

2007

WJG

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neural and chemical control. Myogenic control refers to the electrical activity generated by the smooth muscle of the gut. Electrical control activity (ECA) [1][2][3][4] is the omnipresent rhythmic depolarization of the cell membranes of the smooth muscle of the small intestine. With neural or chemical stimulation, membrane depolarization exceeds an excitation threshold and a contraction results. The electrical correlate of a contraction is called electrical response activity (ERA) [1][2][3][4] . These bursts of electrical response activity have a 1:1 relationship with contractions. Because ERA occurs only during the depolarization phase of the ECA cycle, the frequency of contractions is limited to and determined by the frequency of ECA. Neural and chemical stimulation may not be present during each depolarization of ECA, and thus contractions then do not occur at the maximum possible frequency (Figure 1). Recordings of gastrointestinal motility can either be made with devices that record physical contractions (manometry catheter or strain gauges) or motility can be implied from electrical activity or transit times.Single dose (938 Gy) in a canine model disrupted normal electrical patterns [5] . Jejunal myoelectric activity decreased in frequency, duration and length of migration o f E R A p o s t p r a n d i a l l y. E C A wa s i r r e g u l a r w i t h nonuniform morphology and occasionally migrated in an orad direction. ECA was occasionally uncoupled; coupling is a phenomenon in which corresponding ECAs recorded from different areas maintain a consistent time shift [6] . In spite of these functional abnormalities, the histology was minimally altered. These changes in electrical activity suggest a profound change in the physiology of the smooth muscle as well as the nerves controlling the muscle.Gastrointestinal smooth muscle contractile activity can also be influenced by extrinsic autonomic (parasympathetic and sympathetic) from the CNS and the intrinsic neurons of the enteric ner vous system. The stomach, small intestine and proximal colon derive their parasympathetic innervation through the vagus nerve which contains both afferent and efferent fibers. Relative to the intrinsic enteric neurons, the efferent potion of the vagus is really quite small; however, each vagal efferent fiber may influence about 2000 enteric neurons [7,8] . The sensory component of the vagus nerve is much greater. Sensory fibers account for 80% of all vagal fibers [9] . Vagal afferents detect both the mechanical and chemical stimulation of the small intestine and relay this information centrally for processing. Sympathetic innervation of the intestine arises from the thoracic and lumbar spinal nerves. These �� Effects of radiation upon gastrointestinal motility AbstractWhether due to therapeutic or belligerent exposure, the gastrointestinal effects of irradiation produce symptoms dreaded by a majority of the population. Nausea, vomiting, diarrhea and abdominal cramping are hallmarks of the prodromal ph...

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Gastroduodenal regulation of common duct bile flow in the dog

Cited by 27 publications

References 12 publications

Cholecystokinin, Secretin, Pancreatic Polypeptide in Relation to Gallbladder Dynamics and Gastrointestinal Interdigestive Motility

Cholecystokinin, Secretin, Pancreatic Polypeptide in Relation to Gallbladder Dynamics and Gastrointestinal Interdigestive Motility

Cyclic motility of the sphincter of Oddi

Effects of radiation upon gastrointestinal motility

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