Gastroduodenal erosions in Crohn's disease

Ariyama, J; Wehlin, L; Lindström, C; Wenkert, A.; Roberts, Gareth

doi:10.1007/bf01888615

Cited by 30 publications

(9 citation statements)

References 15 publications

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“…Barium meal studies and upper endoscopy complement each other in establishing a diagnosis of gastroduodenal involvement in Crohn's disease (28). Upper endoscopy and barium meal both dem-onstrated mucosal changes in seven of the 10 cases reported in this study.…”

Section: Discussionsupporting

confidence: 54%

Clinical Features of Gastroduodenal Crohn's Disease in Adolescents

Griffiths,

Alemayehu,

Sherman

1989

J. pediatr. gastroenterol. nutr.

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Ten cases of gastroduodenal inflammation were diagnosed by endoscopy among a series of 196 children with evidence of Crohn's disease involving other regions of the intestinal tract. Endoscopic and histologic confirmation of upper gastrointestinal tract involvement was performed only in those cases with suggestive symptoms. The mean age at presentation in the 10 cases with gastroduodenal inflammation was 14.6 ± 1.9 (±SD) years, with involvement identified at the time of initial diagnosis of Crohn's disease in five of the 10. Eight of 10 cases occurred in boys. The major presenting symptoms were weight loss in five cases, epigastric pain in three, and recurrent vomiting in two. Hematemesis and melena occurred in only one of the 10 cases. Endoscopic and histological evidence of mucosal inflammation was seen in all 10 cases. Three of 10 cases had noncaseating granuloma present in biopsies of the stomach or duodenum. Two cases also had endoscopic and histological evidence of esophageal involvement. All cases were initially treated with oral corticosteroids, and in each instance a good clinical response was noted. Sucralfate (n = 1), 6‐mercaptopurine (n = 1), and H2 receptor antagonists (n = 3) were used as adjunct therapy. After follow‐up for 2.7 years (range, 0.5–5.5 years), none of the 10 cases required surgical intervention. Therefore, at least in the short‐term, the outlook for adolescents with gastroduodenal Crohn's disease appears to be good and their medical management need not differ from those patients with Crohn's disease involving only more distal portions of the small intestine.

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Section: Discussionsupporting

confidence: 54%

Clinical Features of Gastroduodenal Crohn's Disease in Adolescents

Griffiths,

Alemayehu,

Sherman

1989

J. pediatr. gastroenterol. nutr.

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“…a bamboo-jointlike appearance ( while Laufer et al reported that the observation of multiple superficial gastric erosions on double contrast radiography of the stomach was a characteristic finding in the early stage of CD [30]. Subsequently, most reports on gastric lesions in CD patients have focused on erosive lesions in the antropyloric region, the frequency of which was reported to be 24-73% by 1990 [8,31,32]. In CD patients, erosion is frequently observed in the antropyloric region; the characteristics of the erosion include flat reddening, verrucous gastritis and aphthoid erosion-the morphologic features of which include circular and irregularly shaped longitudinally aligned areas of erosion.…”

Section: Gastric Lesionsmentioning

confidence: 99%

The endoscopic findings of the upper gastrointestinal tract in patients with Crohn’s disease

Nomura

Moriichi

Fujiya

et al. 2017

Clin J Gastroenterol

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Crohn's disease (CD) is a type of chronic inflammatory bowel disease (IBD) associated with ulceration, and the main foci of the inflammation in CD patients are typically the terminal ileum and colon. However, in the upper gastrointestinal tract (GIT), including the esophagus, stomach and duodenum, inflammatory lesions are also detected as well, with a relatively high frequency (30-75%). Recent advances in imaging modalities, including endoscopy, have aided in the diagnosis of CD. Various lesions, including aphtha, erosion, ulcers, bamboojoint-like appearance and notch-like appearance, are detected in the upper GI of CD patients. Of these lesions, the bamboo-joint-like appearance in the gastric cardiac region and notch-like appearance in the second portion of the duodenum are highly specific for CD, regardless of the disease activity at other sites. These two findings, particularly a bamboo-joint-like appearance, have therefore been considered as potential biomarkers for CD. Although proton pump inhibitors (PPIs) are administered as an initial treatment for upper GIT lesions of CD, the efficacy of this treatment remains controversial. The administration of mesalazine, steroids, immunosuppressant and biologic agents is expected to be effective for treating such lesions.

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“…Other causes of gastric erosions include alcohol, viral infections, Crohn disease, hemorrhagic gastropathy, and iatrogenic trauma (4,(50)(51)(52)(53)(54)(55). Surprisingly, erosions are infrequently seen in patients with H pylori gastritis (18).…”

Section: Figure 10mentioning

confidence: 99%

Double-Contrast Upper Gastrointestinal Radiography: A Pattern Approach for Diseases of the Stomach

Rubesin¹,

Levine²,

Laufer³

2008

Radiology

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The double-contrast upper gastrointestinal series is a valuable diagnostic test for evaluating structural and functional abnormalities of the stomach. This article will review the normal radiographic anatomy of the stomach. The principles of analyzing double-contrast images will be discussed. A pattern approach for the diagnosis of gastric abnormalities will also be presented, focusing on abnormal mucosal patterns, depressed lesions, protruded lesions, thickened folds, and gastric narrowing.

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Gastroduodenal erosions in Crohn's disease

Cited by 30 publications

References 15 publications

Clinical Features of Gastroduodenal Crohn's Disease in Adolescents

Clinical Features of Gastroduodenal Crohn's Disease in Adolescents

The endoscopic findings of the upper gastrointestinal tract in patients with Crohn’s disease

Double-Contrast Upper Gastrointestinal Radiography: A Pattern Approach for Diseases of the Stomach

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