Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Li, Sizhen; Yang, Qingsong; Zhou, Zhenyu; Yang, Xiaodong; Liu, Yating; Hao, Kuanxiao; Fu, Min

doi:10.1080/21655979.2022.2076499

Cited by 12 publications

(4 citation statements)

References 41 publications

(43 reference statements)

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“…This points to its potential role in treating retinal neurodegenerative diseases marked by retinal ganglion cell death ( Wang et al, 2017 ). Notably, Gastrodin can protect retinal ganglion cells from hypoxia/reoxygenation injury by activating the PI3K/AKT/NRF2 pathway, thus offering potential avenues for glaucoma therapy ( Li S. et al, 2022 ).…”

Section: Modulation Of Mitochondrial Function In Eye Disorders By Nat...mentioning

confidence: 99%

The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction

Sun,

Qu,

Jiang

et al. 2024

Front. Pharmacol.

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The human eye is susceptible to various disorders that affect its structure or function, including glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Mitochondrial dysfunction has been identified as a critical factor in the pathogenesis and progression of eye disorders, making it a potential therapeutic target in the clinic. Natural products have been used in traditional medicine for centuries and continue to play a significant role in modern drug development and clinical therapeutics. Recently, there has been a surge in research exploring the efficacy of natural products in treating eye disorders and their underlying physiological mechanisms. This review aims to discuss the involvement of mitochondrial dysfunction in eye disorders and summarize the recent advances in the application of natural products targeting mitochondria. In addition, we describe the future perspective and challenges in the development of mitochondria-targeting natural products.

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Section: Modulation Of Mitochondrial Function In Eye Disorders By Nat...mentioning

confidence: 99%

The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction

Sun,

Qu,

Jiang

et al. 2024

Front. Pharmacol.

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“…According to Li et al., [92] the treatment with gastrodin was associated with a significant increase in glutathione peroxidase (GSH‐Px) and superoxide dismutase (SOD) levels, and a decrease in the level of the lipid peroxidation end product malondialdehyde (MDA) in the brains of mice. Furthermore, the researchers noted that gastrodin decreased the content of MDA while enhancing the effects of GSH‐Px and SOD, and reduced the production of reactive oxygen species (ROS) in R28 cells with OGD/R induction at a concentration of 100 μM [92] . According to Li et al., gastrodin increased hepatic SOD, GPx, and catalase (CAT) activities in a dose‐dependent manner, decreased hepatic MDA concentration, and suppressed oxidative stress in alcoholic liver disease (ALD) [93] .…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…Furthermore, the researchers noted that gastrodin decreased the content of MDA while enhancing the effects of GSH-Px and SOD, and reduced the production of reactive oxygen species (ROS) in R28 cells with OGD/R induction at a concentration of 100 μM. [92] According to Li et al, gastrodin increased hepatic SOD, GPx, and catalase (CAT) activities in a dose-dependent manner, decreased hepatic MDA concentration, and suppressed oxidative stress in alcoholic liver disease (ALD). [93] Gastrodin reduced the production of ROS to protect cardiomyocytes in cardiovascular disorders, according to Zhu et al [94] The potent antioxidant effect of gastrodin in a variety of in vitro and in vivo models should promote its evaluation in a clinical setting to be designed as an antioxidant therapeutic agent.…”

Section: Antioxidant Activity Of Gastrodinmentioning

confidence: 99%

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

El Menyiy,

Elouafy,

Moubachir

et al. 2024

Chemistry & Biodiversity

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Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.

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“…Primary cultured RGCs treated with tetrandrine maintain the mitochondrial membrane potential and inhibit caspase-3 and Bcl-2 expression after I/R damage ( Li et al, 2014 ). In retinal precursor cells (R28), gastrodin induces the PI3K, Akt, and Nrf2 signaling pathways protectively against oxygen and glucose deprivation/reoxygenation-induced injury ( Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Natural products: protective effects against ischemia-induced retinal injury

Xiao

Shi

et al. 2023

Front. Pharmacol.

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Ischemic retinal damage, a common condition associated with retinal vascular occlusion, glaucoma, diabetic retinopathy, and other eye diseases, threatens the vision of millions of people worldwide. It triggers excessive inflammation, oxidative stress, apoptosis, and vascular dysfunction, leading to the loss and death of retinal ganglion cells. Unfortunately, minority drugs are available for treating retinal ischemic injury diseases, and their safety are limited. Therefore, there is an urgent need to develop more effective treatments for ischemic retinal damage. Natural compounds have been reported to have antioxidant, anti-inflammatory, and antiapoptotic properties that can be used to treat ischemic retinal damage. In addition, many natural compounds have been shown to exhibit biological functions and pharmacological properties relevant to the treatment of cellular and tissue damage. This article reviews the neuroprotective mechanisms of natural compounds involve treating ischemic retinal injury. These natural compounds may serve as treatments for ischemia-induced retinal diseases.

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Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Cited by 12 publications

References 41 publications

The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction

The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Natural products: protective effects against ischemia-induced retinal injury

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