Gastroblastoma in old age

Recent developments in gastroesophageal mesenchymal tumours

“…41 Subsequently, there have also been reports of gastroblastoma occurring in paediatric patients 42,43 and older adults. 44 In the 2019 World Health Organisation (WHO) classification of tumours of the digestive system, gastroblastoma was included in the 'malignant epithelial tumours' section 45 ; however, despite its name, gastroblastoma is not analogous to pancreatoblastoma and hepatoblastoma and, given that it is centred in the muscularis propria and consistently contains a uniform and bland spindle cell component, we believe it is better classified as a mesenchymal neoplasm. Gastroblastoma occurs in the gastric wall and variably involves the subserosa, submucosa and mucosa, in addition to its aforementioned involvement of the muscularis propria.…”

Gastroblastoma with a novel EWSR1‐CTBP1 fusion presenting in adolescence

“…Clinical follow-up is variable, with most patients having no evidence of disease, but two reports describe metastatic disease 1,4 and one individual presented with tumor relapse 5 years after initial diagnosis. 8 None of the previously described cases were reported in patients with pre-existing medical conditions. The contribution of this patient's complex clinical history including Wiskott-Aldrich syndrome and history of multiple allogeneic bone marrow transplants with total body irradiation is unknown.…”

“…These tumors are generally located in the antrum of the stomach. Clinical follow‐up is variable, with most patients having no evidence of disease, but two reports describe metastatic disease 1,4 and one individual presented with tumor relapse 5 years after initial diagnosis 8 . None of the previously described cases were reported in patients with pre‐existing medical conditions.…”

“…This unusual gastric tumor had a characteristic biphasic morphology, with sheets and nests of bland epithelioid cells and clusters of spindled cells, consistent with previous reports of gastroblastoma. Gastroblastomas are extremely rare, with 13 reported cases 1‐10 . They have been reported in patients ranging from 9 to 74 years of age (mean 31 years, median 27.5 years) with a nearly 1:1 female: male ratio.…”

“…Gastroblastomas are extremely rare, with 13 reported cases. [1][2][3][4][5][6][7][8][9][10] They have been reported in patients ranging from 9 to 74 years of age (mean 31 years, median 27.5 years) with a nearly 1:1 female: male ratio. These tumors are generally located in the antrum of the stomach.…”