Gastro-protective effect of<i>Artemisia Sieberi</i>essential oil against ethanol-induced ulcer in rats as revealed via biochemical, histopathological and metabolomics analysis

Ammar, Naglaa M.; Hassan, Heba A.; Ahmed, Rania F.; Gendy, Abd El‐Nasser G. El; Abd‐ElGawad, Ahmed M.; Farrag, Abdel Razik H.; Farag, Mohamed A.; Elshamy, Abdelsamed I.; Afifi, Sherif M.

doi:10.1080/1354750x.2021.2025428

Cited by 14 publications

(9 citation statements)

References 60 publications

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“…The plants belonging to the family Asteraceae were characterised by a high yield of EOs such as Achillea collina Becker ex Heimerl s.l. (0.73%, v / w ) [ 20 ], Artemisia sieberi Besser (0.56–1.02, v / w ) [ 21 ], Achillea fragrantissima (Forssk.) Sch.Bip.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition, Antioxidant, and Cytotoxic Activity of Essential Oils in the Above-Ground Parts of Sonchus oleraceus L.

El Gendy,

Mohamed,

Sarker

et al. 2024

Plants

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Sonchus oleraceus L. is a leafy vegetable that is usually consumed in the area of the Mediterranean and is a frequently used traditional herb to treat a variety of ailments. Previous studies deduced the potent antioxidant and cytotoxic functions of the different extracts and isolated compounds from S. oleraceus. The current study represents the first instance of chemical profiling and bioactivities of the extracted essential oil (EO) of S. oleraceus. The present investigation set out to identify the chemical components of this EO by means of Gas Chromatography with Flame Ionization Detector (GC-FID) and Gas Chromatography-Mass Spectrometry (G004-MS) techniques; assess the oil’s antioxidant potencies through 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonate (ABTS) assays; and evaluate the oil’s cytotoxic impact against HepG2 cancer cell lines. The GC-MS chemical profiling revealed the identification of 23 components representing 97.43% of the total oil mass within abundant cyclic ketones (20.15%), nonterpenoidial hydrocarbons (28.77%), and sesquiterpenes (42.19%). The main components were n-nonadecane (28.77%), trans-caryophyllene (23.73%), trans-methyl dihydrojasmonate (19.55%), and cis-cadina-1,4-diene (9.44%). In a dose-dependent manner, this EO demonstrated antioxidant capacities on DPPH and ABTS, with IC50 values of 609.35 and 804.16 µg/mL, respectively, compared to ascorbic acid. Using doxorubicin as a reference therapy, the MTT assay findings revealed that this oil had remarkable inhibitory effects on the proliferation of HepG2 cancer cell lines, with an IC50 of 136.02 µg/mL. More studies were recommended for further investigation of new biological roles for this oil and its main components, along with the construction of action mechanisms based on chemical components.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition, Antioxidant, and Cytotoxic Activity of Essential Oils in the Above-Ground Parts of Sonchus oleraceus L.

El Gendy,

Mohamed,

Sarker

et al. 2024

Plants

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“…Because metabolite variability and modification are affected by the plant's adaptation to physiological, pathological, and diverse chemical stimuli, metabolomics enables quantitative investigation of these dynamic changes [12]. In-depth food analyses help to uncover discriminatory biomarkers, identify various pathways, find therapeutic targets, and discover new potential drug leads by evaluating and verifying the major variations in metabolite profiling [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative Untargeted Metabolic Profiling of Different Parts of Citrus sinensis Fruits via Liquid Chromatography–Mass Spectrometry Coupled with Multivariate Data Analyses to Unravel Authenticity

Afifi

Kabbash

Berger

et al. 2023

Foods

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Differences between seven authentic samples of Citrus sinensis var. Valencia peel (albedo and flavedo) and juices from Spain and Uruguay, in addition to a concentrate obtained from Brazil, were investigated by untargeted metabolic profiling. Sixty-six metabolites were detected by nano-liquid chromatography coupled to a high-resolution electrospray-ionization quadrupole time-of-flight mass spectrometer (nLC-ESI-qTOF-MS) belonging to phenolic acids, coumarins, flavonoid glycosides, limonoids, terpenes, and fatty acids. Eleven metabolites were detected for the first time in Citrus sinensis and identified as citroside A, sinapic acid pentoside, apigenin-C-hexosyl-O-pentoside, chrysoeriol-C-hexoside, di-hexosyl-diosmetin, perilloside A, gingerol, ionone epoxide hydroxy-sphingenine, xanthomicrol, and coumaryl alcohol-O-hexoside. Some flavonoids were completely absent from the juice, while present most prominently in the Citrus peel, conveying more industrial and economic prospects to the latter. Multivariate data analyses clarified that the differences among orange parts overweighed the geographical source. PCA analysis of ESI-(−)-mode data revealed for hydroxylinoleic acid abundance in flavedo peel from Uruguay the most distant cluster from all others. The PCA analysis of ESI-(+)-mode data provided a clear segregation of the different Citrus sinensis parts primarily due to the large diversity of flavonoids and coumarins among the studied samples.

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“…These phytochemicals are mixtures of chemical compounds, including mainly terpenes, along with other compounds like phenylpropanoid and hydrocarbons [2]. The EOs have been reported to exhibit many potent biological activities such as antiviral [3], antimicrobial [4], antiulcer [5], antipyretic, anti-inflammatory [6,7], antioxidant [8], and hepatoprotective [9], as well as allelopathic effects [10,11].…”

Section: Introductionmentioning

confidence: 99%

Phytotoxicity of Rich Oxygenated Terpenes Essential Oil of Prosopis farcta against the Weed Dactyloctenium aegyptium

et al. 2023

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Weeds are considered the main reason for crop yield loss in the world. Weed control and management include various treatments such as cultural, physical, chemical, and biological methods. Chemical control of weeds is the most common method; however, the application of commercial synthetic herbicides caused several dangerous hazards in the environment including the appearance of resistant weed biotypes. Prosopis farcta (Banks & Sol.) J.F.Macbr. (Family: Fabaceae), is a common weed plant in the Middle East, where it is hard to eliminate due to its deep and overlapped roots. On the other side, it has many traditional uses around the world. Herein, the essential oil (EO) of P. farcta above-ground parts was extracted via hydrodistillation techniques and then analyzed using gas chromatography-mass spectroscopy (GC-MS). From the GC-MS analysis, 47 compounds were identified with a relative concentration of 98.02%, including terpenes as the main components (95.08%). From overall identified compounds, cubenol (19.07%), trans-chrysanthenyl acetate (17.69%), torreyol (8.28%), davana ether (3.50%), camphor (3.35%), and farnesyl acetone (3.13%) represented the abundant constituents. Furthermore, the phytotoxic activity of the P. farcta EO was assessed against the weed Dactyloctenium aegyptium (L.) Willd. The EO of P. farcta, at a concentration of 100 µL L−1, significantly inhibited the germination, seedling shoot growth, and seedling root growth by 64.1, 64.0, and 73.4%, respectively. The results exhibited that the seedling root growth is the most affected followed by the seed germination and seedling shoot growth with respective IC50 at 64.5, 80.5, and 92.9 µL L−1. It can be concluded that weeds are not absolutely harmful, but they may have beneficial uses, such as, for example as a source of phytochemicals with application in weed control practices (bioherbicides). It is advised to conduct additional research to characterize the allelopathic action of the major chemicals in their pure form, either alone or in combination, against a variety of weeds.

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Gastro-protective effect ofArtemisia Sieberiessential oil against ethanol-induced ulcer in rats as revealed via biochemical, histopathological and metabolomics analysis

Cited by 14 publications

References 60 publications

Chemical Composition, Antioxidant, and Cytotoxic Activity of Essential Oils in the Above-Ground Parts of Sonchus oleraceus L.

Chemical Composition, Antioxidant, and Cytotoxic Activity of Essential Oils in the Above-Ground Parts of Sonchus oleraceus L.

Comparative Untargeted Metabolic Profiling of Different Parts of Citrus sinensis Fruits via Liquid Chromatography–Mass Spectrometry Coupled with Multivariate Data Analyses to Unravel Authenticity

Phytotoxicity of Rich Oxygenated Terpenes Essential Oil of Prosopis farcta against the Weed Dactyloctenium aegyptium

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