Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?

Wong, Stephanie; Ruszkiewicz, Andrew; Holloway, Richard H.; Nguyen, Nam Q.

doi:10.4291/wjgp.v9.i3.63

Cited by 6 publications

(5 citation statements)

References 82 publications

(181 reference statements)

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“…This hypothesis is based on the fact that eosinophils disintegrate the mucosal barrier and esophageal smooth muscles leading to remodeling. Remodeling effect, in turn, makes the lower esophageal sphincter lax and impairs acid clearance leading to symptoms of GERD [8].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Eosinophilic Esophagitis in Patients with Refractory Gastroesophageal Reflux Disease

Anis

Chandnani

Ahmed

et al. 2019

Cureus

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IntroductionEosinophilic esophagitis (EoE) is not a common differential diagnosis in patients with longstanding refractory gastroesophageal reflux disease (GERD). The aim of this retrospective analysis was to assess the prevalence of EoE in patients with refractory GERD.MethodsThis retrospective analysis was performed in the Gastroenterology Department of a tertiary care institute in Karachi, Pakistan. Records of esophagogastroduodenoscopy (EGD) with esophageal biopsy from January 2016 till December 2018 were included.ResultsThere were 16 (7.7%) patients of refractory GERD diagnosed with EoE. There were more females than males (5:3). The median age was 58 years (range: 41-63 years). Dysphagia was the chief complaint leading to EGD followed by food impaction and heartburn. The median duration of symptoms was 46.5 months (range: 22-65 months). Erosive esophagitis, white plaques, and friability are common endoscopic findings; however, strictures are also not uncommon.ConclusionEosinophilic esophagitis is not uncommon in patients with refractory GERD. It may present with dysphagia, heartburn, and food impaction. Old patients with longstanding GERD, positive for atopy, not responding to gastric acid inhibitors must be considered for EoE screening via EGD and esophageal biopsy.

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Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Eosinophilic Esophagitis in Patients with Refractory Gastroesophageal Reflux Disease

Anis

Chandnani

Ahmed

et al. 2019

Cureus

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“…When the oesophageal mucosa is exposed to gastroduodenal reflux, it dilates the intercellular spaces. It causes increased paracellular permeability, allowing the noxious components of the refluxate to stimulate sensory nerve endings in the oesophageal mucosa 23 . The pathogenesis of GERD patient's manifestation is still unclear.…”

Section: Discussionmentioning

confidence: 99%

A Study on the Correlation Between Endoscopic Findings and Symptoms of Gastro-Esophageal Reflux Disease

Almani¹,

Keerio²,

Zeb³

et al. 2021

PJMHS

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Background and Aim: Gastroesophageal reflux disease (GERD) is a physiological passage of stomach contents into the esophagus. It is basically the pathological complications and symptoms. Endoscopy is a gold standard investigation tool that eliminates the gastroesophageal reflux disease co-morbidities such as malignancy and Barret’s esophagus. The present study was carried out to evaluate the correlation between endoscopic findings and symptoms of gastroesophageal reflux disease. Materials and Methods: This intervention cross-sectional study was carried out on 109 gastro esophageal reflux disease patients in Gastroenterology department of Isra University Hospital, Hyderabad for six months duration from January 2021 to June 2021. Suspected gastroesophageal reflux disease patients were assessed thoroughly by physical examination, history, and endoscopy for gastrointestinal symptoms. Severity, symptom type, duration, and frequency were assessed as clinical symptoms. The upper gastrointestinal endoscopy findings were evaluated in terms of esophageal erosions, and their grades such as Grade A, Grade B, Grade C, and Grade D. The endoscopy abnormal findings such as hernia, esophagus, malignancy, and Barret’s esophagus were correlated with gastroesophageal reflux disease. Result: Out of 109 patients, 78 (71.5%) were females while 31 (28.5%) were male. The mean age of the patients was 43.54 ± 7.3 years with an age range between 25 and 67 years and the mean BMI was 43.34 ± 5.76 kg/m2. Gastro esophageal reflux disease symptoms such as malignancy and Barrett’s esophagus shown no evidence on pre-operative endoscopy. About 29 (26.6%) patients had normal endoscopy. The symptomatic patients were 80 (73.4%) which were categorized based on LA classifications into Grade A 62 (77.5%), Grade B 13 (16.3%), Grade C 3 (3.8%) and Grade D 2 (2.5%). Based on the reflux score system, patients were distributed as mild 43 (53.8%), moderate 11 (13.8%), severe 5 (6.3%), and very severe 21 (26.3%). Conclusion: Our study found a significant correlation between gastro esophageal reflux disease and endoscopy esophagitis findings. Pre-operative endoscopy should be carried for abnormal endoscopy in both symptomatic and asymptomatic patients. Keywords: Gastro-oesophageal reflux disease, Endoscopy, Esophagitis

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“…Numerous risk factors have been identified through which elements inherent in each individual and external environmental agents cause EoE. The diagnosis of EoE includes esophageal dysfunction symptoms, eosinophil-predominant inflammation on esophageal biopsy and exclusion of other [15]. Dysphagia is the utmost prevalent symptom of EoE among adult patients [16].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of esophageal eosinophilia in patients referred for diagnostic upper gastrointestinal endoscopy

Azizullah¹,

Shahzad²,

Shaukat³

et al. 2023

ijhs

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Background and Aim: Esophageal eosinophilia such as gastro-esophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with several conditions. Esophagus eosinophilic infiltration characterized the Eosinophilic esophagitis (EoE). The purpose of the present study was to determine the esophageal eosinophilia prevalence in patients underwent diagnostic upper gastrointestinal endoscopy. Patients and Methods: This cross-sectional study was carried out on 96 male adult patients underwent upper gastrointestinal endoscopy for unexplained upper GI symptoms in the department of Hepatology & Gastroenterology and Faculty of Medicine, DHQ Hospital Haripur KPK and Type-D Hospital Jamrud District Khyber from June 2022 to November 2022. Patient age>16 years with upper GI symptoms such as nausea, upper abdominal pain, dysphagia, vomiting, and heart burn referred for upper GI endoscopy were enrolled. Individual’s history, demographic details, physical examination, clinical details, laboratory tests such as serum creatinine, CBC, upper GI endoscopy, differential leucocytic count, liver biochemical tests, biopsy, and biopsy staining for histopathological examination were recorded. Data analysis was done in SPSS version 27. Results: Of the total 96 patients, incidence of Esophageal eosinophilia (EE), EoE, and low-grade esophageal eosinophilia was 33.3% (n=32), 5.2% (n=5), and 29.2% (n=28) respectively.

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Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?

Cited by 6 publications

References 82 publications

Retrospective Analysis of Eosinophilic Esophagitis in Patients with Refractory Gastroesophageal Reflux Disease

Retrospective Analysis of Eosinophilic Esophagitis in Patients with Refractory Gastroesophageal Reflux Disease

A Study on the Correlation Between Endoscopic Findings and Symptoms of Gastro-Esophageal Reflux Disease

Prevalence of esophageal eosinophilia in patients referred for diagnostic upper gastrointestinal endoscopy

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