Gastro-Esophageal Reflux and Esophageal Motility Disorders in Morbidly Obese Patients before and after Bariatric Surgery

Merrouche, M.; Sabaté, Jean‐Marc; Jouët, Pauline; Harnois, Florence; Scaringi, Stefano; Coffin, Benoït; Msika, Simon

doi:10.1007/s11695-007-9166-3

Cited by 171 publications

(135 citation statements)

References 30 publications

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“…Most im-portantly, several studies have reported that bariatric surgery might exacerbate or induce new onset GERD-related symptoms in asymptomatic patients undergoing laparoscopic adjustable gastric banding [112][113][114] or laparoscopic sleeve gastrectomy. [115][116][117] Furthermore, Dupree et al 115 reported that up to 9% of patients undergoing sleeve gastrectomy presented with new-onset GERD postoperatively and that approximately 84% continued to have GERD symptoms after the surgery.…”

Section: Bariatric Surgerymentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

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Section: Bariatric Surgerymentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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“…These varied results of weight loss on GERD symptoms could be because of small sample size, gender differences, wide variation in BMI of subjects (23 vs. 43), and use of different weight loss methods (various lifestyle changes vs. surgical approaches) (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Furthermore, a number of lifestyle intervention treatments have been attempted for GERD-low calorie diet, use of fruits/ vegetables, and physical activity; individually each intervention has no direct correlation with GERD improvement as shown in previous population-based studies (13,22,23) and a recent meta-analysis (32).…”

Section: Discussionmentioning

confidence: 99%

“…Previous data on the impact of weight loss achieved through various lifestyle (dietary changes and physical activity) (21)(22)(23)(24)(25) or surgical methods (Roux-en-Y gastric bypass or vertical band gastroplasty) (26)(27)(28)(29)(30) on GERD symptoms are scarce and with conflicting results (31). A systematic review evaluating the effects of various life style changes on GERD symptoms suggested that weight loss and head of bed elevation could improve symptoms of GERD (32).…”

Section: Introductionmentioning

confidence: 99%

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

Singh¹,

Lee²,

Gupta³

et al. 2012

Obesity

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Objective-Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms.Design and Methods-In a prospective cohort study at a tertiary referral center, overweight/ obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire.Results-A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05).Conclusions-In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects.

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“…A obesidade é uma doença crônica caracterizada pelo acúmulo excessivo de gordura corporal, proporcionalmente à massa magra 1,2 . O sobrepeso, segundo a Organização Mundial da Saúde 3 , é considerado um índice de massa corporal variando de 25 a 29,9 kg/m², e a obesidade, como um índice de massa corporal > 30 kg/m² 4 .…”

Section: Introductionunclassified

Impacto da obesidade na saúde bucal: revisão de literatura

Brianezzi¹,

Al-Ahj²,

Prestes³

et al. 2014

Rev. da Fac. de Odontologia, UPF

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As taxas de prevalência e de incidência referentes à obesidade têm se tornado alarmantes, tanto em adultos como em crianças. O acúmulo excessivo de gordura no IntroduçãoA obesidade é uma doença crônica caracterizada pelo acúmulo excessivo de gordura corporal, proporcionalmente à massa magra 1,2 . O sobrepeso, segundo a Organização Mundial da Saúde 3 , é considerado um índice de massa corporal variando de 25 a 29,9 kg/m², e a obesidade, como um índice de massa corporal > 30 kg/m² 4 .A prevalência da obesidade está aumentando tanto em países desenvolvidos como nos subdesenvolvidos. Esse aumento pode ter resultado da transformação no estilo de vida da sociedade moderna, a qual alterou, principalmente, os hábitos alimentares com o aumento do consumo de alimentos processados e o desencorajamento de atividades físicas, levando a um excesso calórico e ao sedentarismo, favorecendo, assim, a obesidade 4 . A prevalência em crianças também está aumentando, e isso pode ser devido a fatores comportamentais, envolvendo educação familiar, visto que crianças com pais obesos têm cerca de 80% mais chance de serem obesas 5 . A obesidade e o sobrepeso favorecem o aparecimento de comorbidades, como doenças cardíacas, hipertensão arterial, osteoartrite, diabetes tipo 2 e alhttp://dx

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Gastro-Esophageal Reflux and Esophageal Motility Disorders in Morbidly Obese Patients before and after Bariatric Surgery

Abstract: GERD and LES incompetence are highly prevalent in morbidly obese patients. Preliminary postoperative data show different effects of RYGBP and AGB on esophageal function, with worsening of pH-metric data with occasional severe dyskinesia after AGB.

Cited by 171 publications

References 30 publications

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

Impacto da obesidade na saúde bucal: revisão de literatura

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