Gastro-esophageal pharmacobezoar

Byard, Roger W.; Grabowski, Marc

doi:10.1007/s12024-021-00404-x

Cited by 4 publications

(10 citation statements)

References 12 publications

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“…Increased availability and promotion of milk formula products during this period are proposed contributors to this phenomenon 19 . The aggregation of pharmaceutical items, such as tablets, suspensions, or drug delivery devices, within the gastrointestinal tract causes the formation of a pharmacobezoar 20 . A growing list of medications has been implicated in pharmacobezoar formation; predisposing factors and pathogenic mechanisms have been recently reviewed by Basílio and Dinis-Oliveira 21 .…”

Section: Discussionmentioning

confidence: 99%

“…The majority of deaths followed intentional overdose; however, accidental deaths have also occurred 23 . Pharmacobezoars contribute to death either by mechanical means, via airway occlusion, or by drug elution and consequent toxic or lethal blood levels 16,20 . A wide range of materials have been implicated in cases of foreign body bezoars.…”

Section: Discussionmentioning

confidence: 99%

“…The authors stated that the PMCT scan identified tablet residues within his stomach. The second is a case of a gastroesophageal pharmacobezoar whereby PMCT demonstrated esophageal distention by granular propranolol and an analogous secondary bolus within the stomach 20 …”

Section: Discussionmentioning

confidence: 99%

“…19 The aggregation of pharmaceutical items, such as tablets, suspensions, or drug delivery devices, within the gastrointestinal tract causes the formation of a pharmacobezoar. 20 A growing list of medications has been implicated in pharmacobezoar formation; predisposing factors and pathogenic mechanisms have been recently reviewed by Basílio and Dinis-Oliveira. 21 At least 14 fatal cases of pharmacobezoars have been reported, involving 9 medication types.…”

Section: Discussionmentioning

confidence: 99%

“…23 Pharmacobezoars contribute to death either by mechanical means, via airway occlusion, or by drug elution and consequent toxic or lethal blood levels. 16,20 A wide range of materials have been implicated in cases of foreign body bezoars. Examples of fatal cases have included death due to copper toxicity after ingestion of 275 coins 24 and a polysubstance bezoar containing broken glass, porcelain, branches, and buttons.…”

Section: Discussionmentioning

confidence: 99%

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Fatal Rapunzel Syndrome

Żyła

Jacques

2023

Am J Forensic Med Pathol

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We report a rare case of a young child, younger than10 years, who died of complications related to trichophagia and multiple gastrointestinal trichobezoars. One year before death, the child's clinical history yielded a diagnosis of iron deficiency anemia, believed to be related to poor diet, and alopecia areata, the etiology of which was unknown. Two weeks before death, the child presented with complaints of intermittent “flu-like” symptoms and vomiting. The child reported abdominal pain, anorexia, and fatigue on the night before death. The next morning, the child ate breakfast and was subsequently discovered unresponsive. On external examination, there were areas of thinning head hair. Postmortem computed tomography, magnetic resonance imaging, and internal examination revealed 3 distinct trichobezoars, occupying the stomach, jejunum, and ileum. This was complicated by small bowel obstructions and perforations due to the trichobezoars. The cause of death was peritonitis secondary to small bowel perforations due to small bowel obstruction with multiple trichobezoars. This is the first case report to demonstrate the utility of postmortem computed tomography and magnetic resonance imaging in characterizing the nature and extent of trichobezoars in a fatal case of Rapunzel syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%