Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological, and ultrastructural findings.

Heilmann, K; Borchard, F

doi:10.1136/gut.32.2.137

Cited by 258 publications

(220 citation statements)

References 8 publications

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“…Heilmannii after Konrad Heilmann who described the first large case study of gastrospirilla infections in humans (Heilmann & Borchard, 1991), e-Proteobacteria, genus Helicobacter, NC. Large helical-shaped cells with five to seven turns, 0?5-0?6 mm65-10 mm in size.…”

Section: Taxonomic Description Of 'Candidatus Helicobacter Heilmannii'mentioning

confidence: 99%

“…A phylogenetic study of two such gastrospirillum isolates from humans found that they were most closely related to Helicobacter felis (Solnick et al, 1993). The name 'Helicobacter heilmannii' was subsequently proposed in honour of the German pathologist Konrad Heilmann, who described a large study of these bacteria in humans (Heilmann & Borchard, 1991). However, analysis of the 16S rRNA gene sequences derived from clones from each patient showed they were not identical (96?6 % similarity) and they subsequently became known as 'H.…”

Section: Introductionmentioning

confidence: 99%

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Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

O’Rourke

Solnick

Neilan

et al. 2004

International Journal of Systematic and Evolutionary Microbiology

127

166

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While Helicobacter pylori is accepted as the major bacterial agent of gastric disease in humans, some patients and many animals are infected with a larger, tightly helical-shaped bacterium previously referred to as ‘Helicobacter heilmannii’ or ‘Gastrospirillum hominis’. Taxonomic classification of these bacteria has been hampered by the inability to cultivate them in vitro and by the inadequate discriminatory power of 16S rRNA gene sequence analysis. This study describes the detection and phylogenetic analysis of 26 different gastrospirillum isolates from humans and animals, which incorporates sequence data based on the 16S rRNA and urease genes. Fifteen gastrospirilla detected in humans, primates and pigs clustered with ‘Candidatus Helicobacter suis’, thus expanding the host range for this organism. By comparison, based on 16S rRNA data, the remaining 11 gastrospirilla could not be differentiated from Helicobacter felis, Helicobacter bizzozeronii and Helicobacter salomonis. However, urease gene sequence analysis allowed for the discrimination of this latter group into four discrete clusters, three of which contained the above recognized species. The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name ‘Candidatus Helicobacter heilmannii’ is proposed.

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Section: Taxonomic Description Of 'Candidatus Helicobacter Heilmannii'mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

O’Rourke

Solnick

Neilan

et al. 2004

International Journal of Systematic and Evolutionary Microbiology

127

166

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show abstract

“…The large gastric spiral organisms elicit a histological gastritis in cats that is similar to that induced by H. pylori. Large gastric spiral bacteria are easily demonstrated histologically (22,32). As is the case with nonhuman primates and humans, however, in which H. pylori can occasionally cocolonize with the large gastric spiral bacteria, H. pylori in cats may be more difficult to visualize by special tissue stains than GHLOs and may be missed with casual review (6,22,46).…”

Section: Discussionmentioning

confidence: 99%

“…In another survey, the lymphoid follicles in H. pylori-infected individuals were much more common in the antrum than in the cardia or body (16), paralleling our findings for cats. Several case reports of GHLO infections in humans have suggested pet animals as possible sources of infection (22,31,32,38,49,51). Recently, an epidemiological study supported the hypothesis that domestic pets were a source of zoonotic spread of GHLOs; however, the data focused on H. felis and Helicobacter heilmannii, not on H. pylori (46).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori induced gastritis in the domestic cat

1995

Gastroenterology

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Helicobacter pylori has been cultured from the inflamed gastric mucosae of naturally infected cats; the lesions in H. pylori-infected cat stomachs mimic many of the features seen in H. pylori-infected human stomachs. To determine whether H. pylori-negative specific-pathogen-free cats with normal gastric mucosae were susceptible to colonization by this bacterium and whether gastritis developed after infections, four H. pylori-negative cats treated with cimetidine were orally dosed three times with 3 ml (1.5 ؋ 10 8 CFU/ml) of H. pylori every 4 days. All four cats became persistently colonized as determined by gastric cultures and PCRs from serial gastric biopsy samples and necropsy samples at 7 months postinfection. H. pylori was not isolated from the two control cats, nor were their gastric tissues positive by PCR; one of the two cats had a few focal lymphocytic aggregates in the body submucosa, whereas the second cat had a normal gastric mucosa. All four H. pylori-infected cats had multifocal gastritis consisting of lymphoid aggregates plus multiple large lymphoid nodules, which were most noticeable in the antral mucosa. In addition, one H. pylori-infected cat had a moderate diffuse infiltration of polymorphonuclear leukocytes in the subglandular region of the antrum. H. pylori-like organisms were focally distributed in glandular crypts of the antrum. Two of the H. pylori-infected cats had significant (eightfold) increases over baseline in levels of immunoglobulin G H. pylori serum antibody. The H. pylori isolates from the four experimentally infected cats had restriction fragment length polymorphism patterns specific for the flaA gene that were identical to those of the inoculating strain. H. pylori readily colonizes the cat stomach and produces persistent gastritis. Since the discovery in 1983 by Warren and Marshall ofHelicobacter pylori as the cause of active chronic gastritis, this new gastric pathogen has been firmly established as the major etiological agent of peptic-ulcer disease, and it is now strongly linked to development of gastric adenocarcinoma and gastric lymphoma (9,13,18,19,24,26,37,40,42,43,52). Although gastric spiral organisms have been observed in dogs and cats for over 90 years, their presence in these species has been largely ignored and they were sometimes cited as gastric commensals (3,23,50). However, because of the tremendous interest in H. pylori as a gastric pathogen, renewed interest has been focused on gastric organisms in animals, the role of these organisms in producing gastric pathology, and their potential as zoonotic gastric pathogens. Animals also have been the subjects of experiments designed to study the pathogenesis and epidemiology of H. pylori. Unfortunately, attempts to infect a variety of animal species with H. pylori were unsuccessful, with the exception of studies with gnotobiotic and (to a lesser extent) specific-pathogen-free pigs, gnotobiotic dogs, Old World macaque species, and most recently, athymic or germfree mice (2,27,28,30,44). Furthermore, early attempts t...

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“…Completeor near complete resolution of symptomshas occured in the majority of patients (8). Spontaneous disappearance of H. heilmannii with the improvement of gastritis has been reported.…”

mentioning

confidence: 99%

<i>Helicobacter heilmannii</i>: A Spiral Shaped Organism Other Than <i>Helicobacter pylori</i>

Haruma

1999

Intern. Med.

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Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological, and ultrastructural findings.

Cited by 258 publications

References 8 publications

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

Helicobacter pylori induced gastritis in the domestic cat

<i>Helicobacter heilmannii</i>: A Spiral Shaped Organism Other Than <i>Helicobacter pylori</i>

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