Gastritis and Gastropathies of Childhood

Dimmick, James E.; Jevon, Gareth

doi:10.1007/978-1-4419-9066-2_3

Cited by 1 publication

(2 citation statements)

References 145 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eosinophilic infiltrates were diagnosed by excessive infiltration by eosinophils above the reference range in the pediatric population in the lamina propria. 16,17 we used >8 eosinophils/40x high power field in gastric antrum. Eosinophilic gastritis was diagnosed by abundant eosinophilic infiltration of lamina propria and epithelium with a lesser number of lymphocytes, plasma cells, and neutrophils in the lamina propria.…”

Section: Methodsmentioning

confidence: 99%

“…15 The criteria used to designate inflammation was established by previous inflammatory cell number studies on biopsies of normal children who had been investigated for upper gastrointestinal symptoms. 16,17 Briefly, IM was diagnosed by the presence of goblet cells in the gastric columnar mucosa. Chronic inactive gastritis was diagnosed by focal or florid chronic mononuclear cell inflammation without neutrophilic infiltrates.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Gastric Antral Mucosal Changes in Children With Intestinal Metaplasia

Kelly

Mroczek‐Musulman

et al. 2022

Pediatr Dev Pathol

View full text Add to dashboard Cite

Objectives: The gastric mucosal change accompanying gastric antral intestinal metaplasia (IM) in the pediatric population and its clinical implications remain unclear. Methods: We retrieved all patients younger than 18 years who had upper GI endoscopy with a pathology diagnosis of antral IM between 2009 and 2020. Each biopsy was evaluated for the presence of dysplasia, Helicobacter pylori, gastritis, and other pathologic changes. Results: A total of 134 patients with antral IM were identified; 72 (53.7%) with coexisting pathology including chronic gastritis (n = 22), reactive gastropathy (n = 16), focal mild chronic inflammation (n = 13), gastric eosinophilia (n = 9), chronic active gastritis associated with (n = 2) and without Helicobacter infection (n = 3), and others (n = 7). The remaining 62 (46.3%) showed isolated IM. Gastric IM increased with age, and was often accompanied by other pathologic changes, especially in female children. Twenty-seven patients had follow up biopsies; 11 of the 27 patients (40.7%) showed persistent IM in at least one repeat biopsies. None demonstrated dysplasia. Conclusions: In children, antral IM increases with age and often coexists with other pathologic changes. Gastric IM could persist for at least months to years in a significant subset of patients with chronic gastritis and gastric eosinophilia.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%