Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus

Lee, Yoomi; Urbanska, Aleksandra M.; Hayakawa, Yoku; Wang, Hongshan; Au, Andrew S.; Luna, Aesis; Chang, Wenju; Jin, Guangchun; Bhagat, Govind; Abrams, Julian A.; Friedman, Richard A.; Varró, Andrea; Wang, Kenneth K.; Boyce, Malcolm; Rustgi, Anil K.; Sepulveda, Antonia R.; Quante, Michael; Wang, Yichen

doi:10.18632/oncotarget.10667

Cited by 55 publications

(59 citation statements)

References 34 publications

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“…In 2015, the method was adapted by researchers at the Cold Spring Harbor Laboratory (Cold Spring Harbor, New York, USA) to model normal and diseased pancreatic ductal tissue. Since then, researchers have established organoid models from many more gastrointestinal cancer specimens derived from the oesophagus, stomach, small intestine, colon, pancreas, liver and biliary epithelium ( Table ).…”

Section: Introductionmentioning

confidence: 99%

Patient-derived organoid models help define personalized management of gastrointestinal cancer

Aberle

Burkhart

Tiriac

et al. 2018

British Journal of Surgery

109

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Background: The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies have failed to improve survival for many tumours. Although promising, the clinical application of molecularly guided personalized treatment has proven to be challenging. This narrative review focuses on the personalization of cancer therapy using patient-derived three-dimensional 'organoid' models.Methods: A PubMed search was conducted to identify relevant articles. An overview of the literature and published protocols is presented, and the implications of these models for patients with cancer, surgeons and oncologists are explained.Results: Organoid culture methods have been established for healthy and diseased tissues from oesophagus, stomach, intestine, pancreas, bile duct and liver. Because organoids can be generated with high efficiency and speed from fine-needle aspirations, biopsies or resection specimens, they can serve as a personal cancer model. Personalized treatment could become a more standard practice by using these cell cultures for extensive molecular diagnosis and drug screening. Drug sensitivity assays can give a clinically actionable sensitivity profile of a patient's tumour. However, the predictive capability of organoid drug screening has not been evaluated in prospective clinical trials. Conclusion:High-throughput drug screening on organoids, combined with next-generation sequencing, proteomic analysis and other state-of-the-art molecular diagnostic methods, can shape cancer treatment to become more effective with fewer side-effects.

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Section: Introductionmentioning

confidence: 99%

Patient-derived organoid models help define personalized management of gastrointestinal cancer

Aberle

Burkhart

Tiriac

et al. 2018

British Journal of Surgery

109

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“…However, it now has become evident that IM is not highly proliferative and likely represents terminally differentiated, postmitotic cells 42 (Figure 1). Indeed, in Barrett’s esophagus, which likely originates from migrated gastric cardia glands,38, 43, 44, 45, 46 goblet cell differentiation is associated with reduced Notch signaling and reduced proliferation,46, 47 and clinically a high goblet cell count is associated with a reduced risk of cancer 48, 49. Greater focus has been given recently to another form of metaplasia called spasmolytic polypeptide-expressing metaplasia (SPEM), which appears more proliferative and shows a stronger association with gastric cancer 50, 51, 52.…”

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confidence: 99%

“…An activated niche can facilitate the development of cancer derived from stem cells, and we and others have defined important cellular components of the gastric stem cell niche, including myofibroblasts, nerves, endothelial cells, innate lymphoid cells, pericytes, tuft cells, and hormone-producing cells20, 45, 57, 68, 85, 86, 87, 88 (Figure 2). Targeting these niche cells may be potentially useful in the inhibition of stem cell expansion and cancer development.…”

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confidence: 99%

The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models

Hayakawa

Fox

Wang

2017

Cellular and Molecular Gastroenterology and Hepatology

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The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer.

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“…Several factors might be related to an increased or decreased risk of Barrett's esophagus and colorectal neoplasms, including the bile acid level, 37-39 gastrin level, 29,40,41 genetic factors, [42][43][44] and treatment with nonsteroidal anti-inflammatory drugs and/or aspirin. 29,[45][46][47][48] The present chart review did not evaluate these factors.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Takedomi

Tsuruoka

Takamori

et al. 2019

J of Gastro and Hepatol

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Background and Aim Barrett's esophagus and colorectal polyps have several overlapping risk factors. Whereas several reports in Western countries have indicated a close relationship between Barrett's esophagus and colorectal polyps, the relationship between these two diseases remains unclear in Japan. This study was performed to determine whether the prevalence of Barrett's esophagus is related to that of colorectal polyps in Japanese patients. Methods The present retrospective chart review included 1582 Japanese patients who underwent both total colonoscopy and esophagogastroduodenoscopy from January 2010 to December 2016. The data on colorectal polyps and Barrett's esophagus were obtained from the endoscopic findings. The medical record of each patient was checked for age, sex, body mass index, smoking, alcohol drinking, use of acid suppression agents, and comorbidities including a history of diabetes, ischemic heart disease, gastroesophageal reflux disease, hiatal hernia, and Helicobacter pylori infection. Results Colorectal polyps were detected in 789 of the 1582 patients (49.9%). Barrett's esophagus was detected in 233 patients (14.7%), and most cases of Barrett's esophagus (n = 229) were classified as short‐segment Barrett's esophagus. Colorectal polyps were more frequent in patients with than without Barrett's esophagus (odds ratio, 1.79; 95% confidence interval, 1.31–2.46; P < 0.001). In addition to Barrett's esophagus, the data indicated that old age, male sex, obesity, smoking, alcohol drinking, diabetes mellitus, and ischemic heart disease were independent risk factors for colorectal polyps. Conclusions The present study revealed the correlation between the prevalence of Barrett's esophagus and colorectal polyps in Japanese patients.

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Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus

Abstract: ABSTRACT

Cited by 55 publications

References 34 publications

Patient-derived organoid models help define personalized management of gastrointestinal cancer

Patient-derived organoid models help define personalized management of gastrointestinal cancer

The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

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