Gastrin Secretion After Bariatric Surgery—Response to a Protein-Rich Mixed Meal Following Roux-En-Y Gastric Bypass and Sleeve Gastrectomy: a Pilot Study in Normoglycemic Women

Grong, Eivind; Græslie, Hallvard; Munkvold, Bjørn; Arbo, Ingerid; Kulseng, Bård; Mårvik, Ronald

doi:10.1007/s11695-015-1985-z

Cited by 23 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During our study, we encountered a few learning points, which, we hope, future researches planning similar research can benefit from and not run into the same problems. We based the feasibility of our protocol on previous studies detailing MMT after RYGB surgery [40,41]. In our study so far, a relatively large number (38 out of 134 participants) of participants exhibited adverse effects during the MMT at the one year after bariatric surgery (nausea, diarrhoea, dizziness and weakness).…”

Section: Lessons Learned So Farmentioning

confidence: 99%

A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

et al. 2020

View full text Add to dashboard Cite

Introduction Prevalence of obesity and associated diseases, including type 2 diabetes mellitus, dyslipidaemia and non‐alcoholic fatty liver disease (NAFLD), are increasing. Underlying mechanisms, especially in humans, are unclear. Bariatric surgery provides the unique opportunity to obtain biopsies and portal vein blood‐samples. Methods The BARIA Study aims to assess how microbiota and their metabolites affect transcription in key tissues and clinical outcome in obese subjects and how baseline anthropometric and metabolic characteristics determine weight loss and glucose homeostasis after bariatric surgery. We phenotype patients undergoing bariatric surgery (predominantly laparoscopic Roux‐en‐Y gastric bypass), before weight loss, with biometrics, dietary and psychological questionnaires, mixed meal test (MMT) and collect fecal‐samples and intra‐operative biopsies from liver, adipose tissues and jejunum. We aim to include 1500 patients. A subset (approximately 25%) will undergo intra‐operative portal vein blood‐sampling. Fecal‐samples are analyzed with shotgun metagenomics and targeted metabolomics, fasted and postprandial plasma‐samples are subjected to metabolomics, and RNA is extracted from the tissues for RNAseq‐analyses. Data will be integrated using state‐of‐the‐art neuronal networks and metabolic modeling. Patient follow‐up will be ten years. Results Preoperative MMT of 170 patients were analysed and clear differences were observed in glucose homeostasis between individuals. Repeated MMT in 10 patients showed satisfactory intra‐individual reproducibility, with differences in plasma glucose, insulin and triglycerides within 20% of the mean difference. Conclusion The BARIA study can add more understanding in how gut‐microbiota affect metabolism, especially with regard to obesity, glucose metabolism and NAFLD. Identification of key factors may provide diagnostic and therapeutic leads to control the obesity‐associated disease epidemic.

show abstract

Section: Lessons Learned So Farmentioning

confidence: 99%

A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It has been suggested that excessive gastric acid production maybe involved in the pathogenesis of abnormal histological findings in the stomach after RYGB [ 10 ]. Grong et al used a protein-rich mixed meal on a cohort of 20 female patients previously operated with RYGB or SG versus 13 female matched controls and were able to demonstrate diminished gastrin levels in the RYGB but no statistically significant changes between the SG group and controls [ 11 ]. A study of 24 patients following GB demonstrated no change in fasting gastrin concentrations 6–12 months after surgery [ 12 ].…”

Section: Bariatric Surgery and Gut Hormonesmentioning

confidence: 99%

Potential Hormone Mechanisms of Bariatric Surgery

2017

View full text Add to dashboard Cite

Purpose of ReviewIn recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.Recent FindingsBariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response.SummaryThis review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.

show abstract

“…According to our study, we did not find evidence that hypergastrinemia might improve glucose control, as SHAM and EDG groups had similar level of plasma gastrin postoperatively, and yet only EDG group had glucose control improvements. Hypergastrinemia was also not found clinically following RYGB and SG procedures 48,49 , though one animal study suggested otherwise 50 . Furthermore, the effect of PPI on diabetes is still controversial, as one study did not found improvements on the glycated haemoglobin following interventions 51 .…”

Section: Discussionmentioning

confidence: 99%

Bypassed and Preserved Stomach Resulted in Superior Glucose Control in Sprague-Dawley Rats with Streptozotocin-Induced Diabetes

Widjaja

Dolo

Zhang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Recent studies suggest the possibility of the stomach playing a role in diabetes remission after bariatric surgery. In this study, we investigated whether bypassing the stomach alleviates diabetes in diabetic rodent model. Eighteen moderately obese and diabetic Sprague-Dawley rats were randomly assigned to Esophagoduodenostomy with or without gastric preservation (EDG and EDNG/total gastrectomy, respectively), and SHAM groups. Bodyweight, food intake, fasting glucose level, oral glucose tolerance test result (OGTT), and hormone levels (insulin, glucagon-like peptide-1, ghrelin, gastrin and glucagon) were measured preoperative and postoperatively. Postoperatively, bodyweight and food intake did not differ significantly between the EDG and EDNG groups. Postoperative fasting blood glucose and OGTT results declined significantly in the EDG and EDNG group when compared with the respective preoperative levels. Postoperative glucose control improvements in EDNG group was significantly inferior when compared to EDG. Compared preoperatively, postoperative plasma ghrelin and gastrin levels declined significantly in EDNG group. Preoperative and postoperative plasma GLP-1 level did not differ significantly among all the groups. Postoperatively, EDG group had significantly higher insulin and lower glucagon levels when compared with SHAM. In conclusion, bypassing and preserving the stomach resulted in superior glucose control improvements than total gastrectomy.

show abstract

Gastrin Secretion After Bariatric Surgery—Response to a Protein-Rich Mixed Meal Following Roux-En-Y Gastric Bypass and Sleeve Gastrectomy: a Pilot Study in Normoglycemic Women

Abstract: Gastrin secretion is diminished after RYGB. Hypergastrinemia was not present after SG, but a tendency of enhanced gastrin secretion was observed. These findings require further investigation in prospective studies.

Cited by 23 publications

References 43 publications

A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

Potential Hormone Mechanisms of Bariatric Surgery

Bypassed and Preserved Stomach Resulted in Superior Glucose Control in Sprague-Dawley Rats with Streptozotocin-Induced Diabetes

Contact Info

Product

Resources

About