Gastrin-Releasing Peptide Mediates Light-Like Resetting of the Suprachiasmatic Nucleus Circadian Pacemaker through cAMP Response Element-Binding Protein and<i>Per1</i>Activation

Gamble, Karen L.; Allen, Gregg C.; Zhou, Tongrong; McMahon, Douglas G.

doi:10.1523/jneurosci.1109-07.2007

Cited by 85 publications

(81 citation statements)

References 55 publications

(93 reference statements)

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“…Light pulses induced immediate early gene expression in GRP-containing SCN neurons, and the levels of GRP and GRP mRNA within the rat SCN were altered by photic conditions. Microinjection of GRP into the third ventricle or SCN induced circadian phase shifts similar to those produced by light, and GRPR-deWcient mice showed a dysfunctional photic phase shifting (Gamble et al 2007;Sterniczuk et al 2010). These data indicated that GRP promotes the shift of circadian rhythms in SCN, and dysregulation of GRP diurnal rhythms may be an important mechanism for cancer progression under chronic stress (Fig.…”

Section: Grp Regulates Circadian Rhythmsmentioning

confidence: 69%

“…However, the mechanisms of GRP aVecting cancer cell cycle rhythms remain unclear. If the GRP in cancer cells has the eVect similar to that in SCN, to induce the expression of circadian genes such as Per1 or Per2 (Gamble et al 2007), it might have some tumor suppressor functions. In contrast to this hypothesis, a number of studies indicated that GRP acts as a mitogen to promote cancer growth.…”

Section: Grp Regulates Circadian Rhythmsmentioning

confidence: 99%

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Gastrin-releasing peptide links stressor to cancer progression

Yuan

et al. 2010

J Cancer Res Clin Oncol

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Section: Grp Regulates Circadian Rhythmsmentioning

confidence: 69%

Section: Grp Regulates Circadian Rhythmsmentioning

confidence: 99%

Gastrin-releasing peptide links stressor to cancer progression

Yuan

et al. 2010

J Cancer Res Clin Oncol

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“…Glutamate-induced Period 1 gene expression is also blocked by pretreatment with CRE decoys [69]. Gastrin-releasing peptide (GRP) mimics some of the effects of a light pulse when it is applied to the SCN (see below) [70,71] and inhibiting the activity of CREB using CRE decoy oligonucleotides prevents GRP-induced expression of Period 1 [72].…”

Section: Creb Regulationmentioning

confidence: 99%

Physiological responses of the circadian clock to acute light exposure at night

Antle

Smith

Sterniczuk

et al. 2009

Rev Endocr Metab Disord

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Circadian rhythms in physiological, endocrine and metabolic functioning are controlled by a neural clock located in the suprachiasmatic nucleus (SCN). This structure is endogenously rhythmic and the phase of this rhythm can be reset by light information from the eye. A key feature of the SCN is that while it is a small structure containing on the order of about 20,000 cells, it is amazingly heterogeneous. It is likely that anatomical heterogeneity reflects an underlying functional heterogeneity. In this review, we examine the physiological responses of cells in the SCN to light stimuli that reset the phase of the circadian clock, highlighting where possible the spatial pattern of such responses. Increases in intracellular calcium are an important signal in response to light, and this increase triggers many biochemical cascades that mediate responses to light. Furthermore, only some cells in the SCN are actually endogenously rhythmic, and these cells likely do not receive strong direct input from the retina. Therefore, this review also considers how light information is conveyed from the retinorecipient cells to the endogenously rhythmic cells that track circadian phase. A number of neuropeptides, including vasoactive intestinal polypeptide, gastrin-releasing peptide and substance P, may be particularly important in relaying such signals, but other neurochemicals such as GABA and nitric oxide may participate as well. A thorough understanding of the intracellular and intercellular responses to light, as well as the spatial arrangements of such responses may help identify important pharmacological targets for therapeutic interventions to treat sleep and circadian disorders.

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“…Light entrainment results in a rapid increase of PER1 expression. The SCN neurons are synchronized and the signal spreads to the dorsal 'shell' region of the SCN via mechanisms that are incompletely understood but involve the neuropeptides gastrin-releasing peptide (GRP) and vasoactive intestinal peptide (VIP) 26,27 and fast-delayed rectifier (FDR) K + channels. 28 The SCN controls physiological outputs such as body temperature, feeding behaviour and timed hormone release via anatomically complex pathways involving either pre-autonomic or neuroendocrine neurons (for an overview, see Kalsbeek et al 29 ).…”

Section: Resetting the Clockmentioning

confidence: 99%

Rhythm of digestion: keeping time in the gastrointestinal tract

Bron

Furness

2009

Clin Exp Pharma Physio

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1. The best characterized mammalian circadian rhythms follow a light-entrained central master pacemaker in the suprachiasmatic nucleus and are associated with fluctuations in the activities of clock genes, including Clock, Bmal1, Per and Cry, the products of which bind to sequences in the promoters of effector genes. This is the central clock. 2. In the present review, we discuss evidence for an independent, but interacting, gut-associated circadian clock, the peripheral clock, which is entrained by food. 3. Disruption of circadian rhythms is associated with a wide range of pathologies, most prominently metabolism linked, but the effects of disruption of circadian rhythms on the digestive system are less well studied, although also likely to lead to functional consequences. There are clues suggestive of links between gastrointestinal disorders related to inflammation, cancer and motility and disruption of peripheral rhythms. Research aimed at understanding these links is still in its infancy. 4. We also discuss practical aspects of the presence of circadian rhythms in gastrointestinal tissues for researchers related to experimental design, data interpretation and the choice of animal models. 5. There is currently sufficient evidence to suggest that circadian rhythms are important to gut function, metabolism and mucosal defence and that further investigation will uncover connections between disordered rhythms and gastrointestinal malfunction.

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Gastrin-Releasing Peptide Mediates Light-Like Resetting of the Suprachiasmatic Nucleus Circadian Pacemaker through cAMP Response Element-Binding Protein andPer1Activation

Cited by 85 publications

References 55 publications

Gastrin-releasing peptide links stressor to cancer progression

Gastrin-releasing peptide links stressor to cancer progression

Physiological responses of the circadian clock to acute light exposure at night

Rhythm of digestion: keeping time in the gastrointestinal tract

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