Gastric Ulceration and Haemorrhage as a Potential Cause of Experimental Failure Following Renal Allografting in Pigs

Abstract

It has been reported that gastric ulceration occurs in pigs with no apparent relationship between incidence and breed. In a series of pigs, with orthotopic renal allografts, it has been bound that severe gastric ulceration with fatal haemorrhage is more common among Large White × Wessex pigs than Large White × Landrace/Wessex pigs. It is concluded that there is a significant breed difference in severity of gastric ulceration. Haemorrhage from such ulceration is a potential cause of death in animals receiving organ transplants.

Postoperative death in sows as a result of gastric mucosal de-gloving at the pars oesophagea

“…Subsequently, cases have been intermittently reported in experimental studies using pigs. These animals are often found to die 5-10 days after major surgery, such as liver or renal transplantation, due to massive haemorrhage from the lesion (Dent et al 1971, Golby et al 1971. The incidence of ulcerative lesions does not appear to be operation-specific; however, bile duct ligation is quoted as having a 100% incidence of ulceration with 60% mortality, and a relationship with biliary obstruction has been proposed (Dent et al 1971).…”

Perductal electrolytic ablation of the porcine pancreas: A minimally invasive option-studies of morbidity and mortality

“…The premature deaths were due to gastric dilatation and ulceration with subsequent hemorrhage, a wellrecognized phenomenon in postoperative pigs as previously mentioned [3][4][5]7]. Indeed, female pigs are susceptible to gastric dilatation and resultant death when intensively farmed, even without the added stress of surgery [22].…”