Gastric Ulcer With Massive Hemorrhage Following Use of Phenylbutazone

Krainin, Philip

doi:10.1001/jama.1953.63690010007007f

Cited by 26 publications

(2 citation statements)

References 4 publications

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“…Phenylbutazone was introduced to clinical use in 1949, and promptly a number of case‐reports appeared of peptic ulcer with perforation or hemorrhage in patients taking this first of the non‐aspirin NSAIDs 33–37 . Similar reports began to appear soon after indomethacin became available 38 …”

Section: Nonsteroidal Anti‐inflammatory Drugsmentioning

confidence: 99%

The ulcer sleuths: The search for the cause of peptic ulcers

Yeomans

2011

J of Gastro and Hepatol

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The search for the cause or causes of peptic ulcers has been a long one. It was recognised as early as the 19th Century that damage to the stomach or duodenal bulb was likely to result if the resistance of their mucosae to luminal acid was for some reason impaired. An early theory suggested microscopic vascular occlusion leading to local infarction could be the initiating event but evidence was lacking. Excessive acid secretion is seen in some patients but not in many so is implausible as the main factor in most ulcers. Cigarette smoking is a risk factor and chronic life difficulties has been shown to sometimes play a part, but we would now think that they play only minor roles to possibly tip the balance when a major etiologic factor is already present. The overwhelming evidence now is that the major etiologic factors in chronic peptic ulcer are ingestion of nonsteroidal antiinflammatory drugs (NSAIDs) and infection with Helicobacter pylori. Understanding the mechanism of the first, and the discovery and demonstration of Koch's postulates for the second, have been instrumental in the award of two Nobel prizes.

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Section: Nonsteroidal Anti‐inflammatory Drugsmentioning

confidence: 99%

The ulcer sleuths: The search for the cause of peptic ulcers

Yeomans

2011

J of Gastro and Hepatol

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“…Кроме того, фенилбутазон может считаться первым НПВП, для которого было четко доказано наличие ульцерогенности. Ведь если негативное действие аспирина на желудочнокишечный тракт (ЖКТ) долгое время оценивалось как «раздражающее», то про фенилбутазон уже в начале 50-х годов было известно, что он способен вызывать язвы, кровотечения и перфорации [42][43][44]. Естественно, что в подавляющем большинстве стран фенилбутазон был запрещен к использованию у людей и перешел в ветеринарную практику [37].…”

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A concise course of the history of NSAIDs

Каратеев¹,

Uspensky²,

Pakhomova³

et al. 2012

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Treatment of Superficial Thrombophlebitis With Phenylbutazone (Butazolidin)

Stein¹

1954

Arch Intern Med

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IN THE medical management of thrombophlebitis, reliance is placed almost completely on bed rest with elevation of the extremity, hot or cold applications, and anticoagulant therapy. Analgesics are frequently used to control pain and antibiotics to combat the chills and fever which sometimes dominate the clinical picture. The latter are of doubtful value, except in the rare case of purulent or septic phlebitis due to bacterial organisms.These measures, when aided by the factor of time, will cause resolution of the thrombophlebitis in most instances in from one to four weeks.There remains, however, a small but important group in whom, despite such therapy, the inflammation in the veins and adjacent tissues may remain active, resulting in considerable disability and economic loss. An agent capable of producing rapid and sustained improvement or subsidence of the phlebitis in these refractory cases would be valuable.Phenylbutazone (Butazolidin) has been found to bring about prompt and frequently dramatic resolution of acute inflammatory conditions, including rheumatoid arthritis, gout, and peritendinitis.* It has relieved psoriatic dermatitis accompanying arthritis 3 and has recently been reported to have been effective in the treatment of erythema nodosum.4 Because of its anti-inflammatory action in these nonspecific and unrelated conditions, phenylbutazone was tried on patients with thrombo¬ phlebitis. METHODOur criteria for the selection of cases were (1) the presence of an active phlebitis, which had persisted in most instances in spite of treatment, and (2) such activity to be present pri¬ marily in the superficial veins, to obviate any difficulty in establishing the diagnosis or in study¬ ing the effect of treatment.Of the 33 patients studied, seven were from hospital wards and outpatient clinics ; the other 26 were seen in private practice at the office. With the exception of two patients, all had been on bed rest for periods of from two to six weeks, receiving the measures outlined in Table 2. These two (Cases 5 and 13) were treated after onset of phlebitis, for reasons outlined in the appended case reports.

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Gastric Ulcer With Massive Hemorrhage Following Use of Phenylbutazone

Cited by 26 publications

References 4 publications

The ulcer sleuths: The search for the cause of peptic ulcers

The ulcer sleuths: The search for the cause of peptic ulcers

A concise course of the history of NSAIDs

Treatment of Superficial Thrombophlebitis With Phenylbutazone (Butazolidin)

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