Gastric Ulcer Etiology

Silva, Maria Izabel Gomes; Sousa, Francisca Cléa Florenço de

doi:10.5772/20796

Cited by 13 publications

(4 citation statements)

References 125 publications

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“…lead to commonly gastric ulceration (Farzaei, Abdollahi, & Rahimi, ). ROS are related to the various diseases such as neurodegenerative disorders, autoimmune pathologies, gastrointestinal inflammation, and gastric ulcer (Gomes Silva & de Sous, ). The imbalance of ROS and antioxidants in the stomach can cause hemorrhage and ulcer formation (Hung, ).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

et al. 2019

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This study focused on the concept of the possible protective effect of some honey types against HCl/ethanol‐induced gastric ulcers in male Wistar albino rats. Rats were pretreated with rhododendron, chestnut, and oak honey orally with doses of 1.25 and 2.5 g/kg, bw (body weight) for three consecutive days. On fourth day, nothing was applied, and after the administration of anesthesia on the fifth day, their stomachs were surgically removed to investigate the histopathological examinations. Besides analyses of some blood serum profiles and antioxidant parameters of gastric tissue, some biochemical properties of honeys were investigated to support the histopathological results. The degrees of ulcer lesions in all groups revealed a statistically significant difference (p = .011). Although this difference originated from the additional ulcerative inducing effect of some honeys, the lower concentration rhododendron honey indicated more promising data than the positive control group (pantoprazole) in consequence of the microscopic and macroscopic evaluations. Practical applications As being a member of natural products, honey has acquired fame among the studies in recent years due to its versatility as a source of food and complementary medicine. For contributing to this argument, this comprehensive study was performed and results were focused on the lower concentration of rhododendron honey thanks to its clinical potential with protecting the gastric mucosa. According to the obtained results, our suggestion came into prominence that this honey might be protecting the mucosa, better than the different concentrations of chestnut and oak honeys, by being better‐absorbed through the gastric mucosa.

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Section: Discussionmentioning

confidence: 99%

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

et al. 2019

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“…Chronic ulcers are open sores that endure a long time-usually more than six weeks-and frequently come back even after therapy [39]. These ulcers can develop in the epidermis, stomach, duodenum, or esophagus, among other places.…”

Section: • Chronic Ulcersmentioning

confidence: 99%

Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice

Sultana,

Basha,

Teja

et al. 2024

UPJOZ

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Ulcerative stomach disease continues to be a prevalent gastrointestinal illness associated with high worldwide morbidity and medical costs. While nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection are well-known risk factors for the development of peptic ulcers, recent evidence suggests a complex interaction between host factors and the gut microbiota in ulcer etiology. This study provides a comprehensive review of recent research investigating the relationship between the genesis and progression of peptic ulcers and dysbiosis of the gut microbiota. The study highlights several natural compounds, such as flavonoids, polyphenols, alkaloids, and polysaccharides, that have demonstrated anti-ulcer activity in experimental models and clinical trials. Mechanistic understanding clarifies the many pathways, including antibacterial, anti-inflammatory, and antioxidant ones, through which these drugs perform their medicinal effects. It is interesting to note that many natural compounds focus on many pathogenic procedures that aid in the development and spread of ulcers, resulting in multifactorial effects. Albizia odoratissima is a member of the Fabaceae family and has been used traditionally in many folk medicines due to its medicinal characteristics. This study used experimental models of stomach ulceration to investigate potential anti-ulcer properties of methanolic bark extract from Albizia odoratissima (MAO). The anti-ulcer qualities of MAO were evaluated in rats using models of stomach ulceration brought on by HCL. Many parameters were assessed when different doses of MAO were administered orally, including the ulcer index, mucosal injury to the stomach, mucin content, and antioxidant enzyme levels. Additionally, a histological analysis was carried out to evaluate the possible protective qualities of MAO against harm to the stomach mucosa.

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“…[2,3] Recent reports suggest that NSAID-induced gastric ulcers are on the rise due to the increasing success of eradication programs targeting the decline in H. pylori infections, thus increasing the clinical importance of these ulcers. [4] Epidemiological data suggest that up to 20 % of NSAID users develop gastric ulcers, which may result in severe complications. [5] Several attempts have been made to reduce the risk of gastric ulceration.…”

Section: Introductionmentioning

confidence: 99%

“…It is mainly associated with Helicobacter pylori infection, as well as the use of nonsteroidal anti‐inflammatory drugs (NSAIDs) or aspirin, which promote the development of gastric ulcers by disrupting the defense system of the gastric mucosa [2,3] . Recent reports suggest that NSAID‐induced gastric ulcers are on the rise due to the increasing success of eradication programs targeting the decline in H. pylori infections, thus increasing the clinical importance of these ulcers [4] . Epidemiological data suggest that up to 20 % of NSAID users develop gastric ulcers, which may result in severe complications [5] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acetic Acid‐Induced Chronic Gastric Ulcer Healing by Propionyl‐L‐Carnitine Administration

İpek

Aşıcı

Epikmen

et al. 2023

Chemistry & Biodiversity

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The aim of our study was to investigate the healing effect of propionyl‐L‐carnitine (PLC) on chronic gastric ulcers and its underlying mechanisms. This study included rats with gastric ulcers induced by applying serosal glacial acetic acid. These rats were then given either saline (vehicle) or PLC at doses of 60 and 120 mg/kg, administered orally 3 days after ulcer induction for 14 consecutive days. Our study found that treatment with PLC resulted in a reduction of the gastric ulcer area, a faster rate of ulcer healing, and stimulated mucosal restoration. Additionally, the treatment with PLC reduced the number of Iba‐1+ M1 macrophages while increasing the number of galectin‐3+ M2 macrophages, as well as desmin+ microvessels, and α‐SMA+ myofibroblasts in the gastric ulcer bed. The mRNA expression of COX‐2, eNOS, TGF‐β1, VEGFA, and EGF in the ulcerated gastric mucosa was greater in the PLC‐treated groups compared with the vehicle‐treated rats. In conclusion, these findings suggest that PLC treatment may accelerate gastric ulcer healing by stimulating mucosal reconstruction, macrophage polarization, angiogenesis, and fibroblast proliferation, as well as fibroblast‐myofibroblast transition. This process is associated with the upregulation of TGF‐β1, VEGFA, and EGF, as well as modulation of the cyclooxygenase/nitric oxide synthase systems.

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Gastric Ulcer Etiology

Cited by 13 publications

References 125 publications

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

Alleviating Ulcer Burdens Examining the Potential of Albizia Odoratissima Bark Extract as a Therapeutic Agent in Mice

Evaluation of Acetic Acid‐Induced Chronic Gastric Ulcer Healing by Propionyl‐L‐Carnitine Administration

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