Gastric synovial sarcoma: a case report and literature review

Wong, HK; Law, Simon; Collins, Robert A.

doi:10.12809/hkmj197986

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…Due to discrepancy in the receptor status of primary breast tumor and bladder metastasis, histology and immunohistochemistry with staining for ER, PR, and HER2 is crucial. 7 , 11 An important histological marker, gross cystic disease fluid fibrous protein-15 (GCDFP-15 or BRST-2) is present on breast cancer with apocrine features and is used to differentiate between breast and primary bladder tumors. 12 In our patient, the bladder metastasis tested positive for ER and PR receptors, GCDF-15, and was negative for HER2.…”

Section: Discussionmentioning

confidence: 99%

Hormone Receptor Positive/HER2 Negative Breast Cancer With Isolated Bladder Metastasis: A Rare Case

Khan

Abdallah

Tirona

2021

Journal of Investigative Medicine High Impact Case Reports

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Breast cancer is the most common cancer diagnosed in women in North America. Hormone receptor positive (HR+) and HER2 negative (HER2−) breast cancers account for at least 60% to 70% of all breast cancer cases. They usually metastasize to lymph nodes, bones, liver, lungs, and brain. Urinary bladder is a very unusual site for metastatic HR+/HER2− breast cancer and occurs in only 2% of all metastatic disease. In this article, we present a case of a 63-year-old female with locally advanced breast cancer who underwent mastectomy, adjuvant chemotherapy, radiation, and hormonal therapy. She was in remission for almost 17 years and subsequently presented with hematuria and lower abdominal pain. Cystoscopy was performed, which showed evidence of bladder wall thickening. Histopathology showed metastatic HR+/HER2− breast cancer consistent with her history of breast primary. Imaging studies did not show any other evidence of metastatic disease. She was started on cyclin D kinase 4/6 inhibitor, palbociclib, in combination with an aromatase inhibitor, letrozole. This is an exceedingly rare case of HR+ and HER2− breast cancer with metastasis to the urinary bladder. The late onset of recurrence with bladder metastasis makes this case very unique and to our knowledge only few similar cases have been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Hormone Receptor Positive/HER2 Negative Breast Cancer With Isolated Bladder Metastasis: A Rare Case

Khan

Abdallah

Tirona

2021

Journal of Investigative Medicine High Impact Case Reports

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“…On the other hand, chemotherapy is not recommended for patients with tumors less than 5 cm in diameter and R0 resections [ 30 ]. In the cases of gastric synovial sarcoma, adjuvant chemotherapy was administered in eight patients with tumor diameters of 60 mm or greater [ 5 – 7 , 13 , 20 , 22 , 24 ]. Six of eight patients treated with adjuvant chemotherapy had recurrence, and two of these patients died [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…When enlarged, other subepithelial tumors show the same central ulceration, but when small tumors are accompanied by ulceration, the possibility of synovial sarcoma should be kept in mind. The smallest case previously reported was 8 mm in diameter [ 6 ], and five cases were in the 10 mm range [ 6 , 15 , 22 , 25 ]. All of them underwent wedge resection or partial resection, and none of the described cases were treated with additional therapy, and no recurrence was reported.…”

Section: Discussionmentioning

confidence: 99%

A minute primary gastric synovial sarcoma with ulcer: a case report

et al. 2021

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Background Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric synovial sarcoma. Case presentation A 61-year-old Japanese woman was pointed out edematous erosion at the body of the stomach. Biopsy specimen showed dense proliferation of spindle-shaped tumor cells mixed with smooth muscle fibers of the muscularis mucosae. Although the definite histological diagnosis was undetermined, the patient underwent laparoscopic wedge resection of the stomach. Histological examination of the resected sample revealed that the maximum diameter of the tumor was only 6 mm and that dense proliferation of rather uniform spindle tumor cells were observed mainly in the submucosa. Immunohistochemistry showed that they were positive for pan-keratin, CD99 and TLE1. SS18-SSX fusion-specific antibody gave diffuse positive staining to the tumor cells, and analysis using mRNA extracted from paraffin sections revealed that the tumor had SS18-SSX1 fusion gene. Thus, it was diagnosed as gastric synovial sarcoma, monophasic fibrous type. Conclusions Primary synovial sarcoma of the stomach is rare and only 47 cases have been reported in the English literature to date. The maximum diameter of the lesion of our case was 6 mm which is the smallest among them.

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“…The first report con-cerning primary gastric SS was published in 2000 by Billings et al [3]. The last two cases were reported by Manohar et al [19] and Wong et al [20] in 2020. The clinicopathological features of the 37 cases of primary gastric SS, including our case, are summarized in Table II.…”

Section: Discussionmentioning

confidence: 99%

“…Although the gastrointestinal tract is an extremely rare location for synovial sarcoma, this type of presentation has also been previously described and the stomach is the most frequent location along the digestive tract. To the best of our knowledge, only 36 primary gastric synovial sarcoma cases have been reported in the English literature [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. We present an additional case of primary gastric synovial sarcoma in a 48-year-old female.…”

Section: Introductionmentioning

confidence: 99%

Synovial sarcoma of the stomach: case report and systematic review of the literature

Kurpińska

Kaznowska

Kruczak

et al. 2020

pjp

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Synovial sarcoma is a rare mesenchymal malignant neoplasm that presents a specific t(X;18) translocation forming SS18(SYT)-SSX chimera gene. It is most commonly seen in soft tissues of the extremities. The digestive tract is an exceptional site of involvement. We report a case of primary gastric synovial sarcoma in a 48-year-old female. Differential diagnosis of synovial sarcoma from other spindle cell, mesenchymal and cytokeratin-positive tumors is critical for the treatment and prognosis. Immunohistochemistry studies and molecular analysis are required to settle a proper diagnosis.

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Gastric synovial sarcoma: a case report and literature review

Cited by 9 publications

References 21 publications

Hormone Receptor Positive/HER2 Negative Breast Cancer With Isolated Bladder Metastasis: A Rare Case

Hormone Receptor Positive/HER2 Negative Breast Cancer With Isolated Bladder Metastasis: A Rare Case

A minute primary gastric synovial sarcoma with ulcer: a case report

Synovial sarcoma of the stomach: case report and systematic review of the literature

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