Gastric structure and function in iron-deficient piglets

Larkin, H.; Hannan, John H.

doi:10.1016/s0034-5288(18)32273-2

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…The most likely scenario points to the necessity of iron for normal gastric secretion. In the other words, the incidence of neonatal diarrhea in anemic calves may be a reflection of the alteration in gastric function and consequently imbalance in the gastrointestinal tract microbiota, as was previously described in irondeficient piglets (Larkin and Hannan, 1985;1983). A similar explanation may exist for the observation that acidification of milk with dilute hydrochloric acid was effective in reducing diarrhea in anemic calves (Blaxter et al, 1957).…”

Section: Discussionsupporting

confidence: 52%

“…The monitoring of iron status in newborn calves is essential not only for the achievement of good health but also for the achievement of adequate weight gain of young calves due to the involvement of the insulin-like growth factor (IGF) system in proper utilization of consumed nutrients (Prodanovic et al, 2014). A high incidence of diarrhea is a commonly detected in irondeficient piglets (Larkin and Hannan, 1983). Changes in the morphology, function and bacterial microbiota of the small intestine have also been recorded (Larkin and Hannan, 1985).…”

Section: Introductionmentioning

confidence: 99%

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Occurrence of neonatal diarrhea in calves with iron-deficiency anemia

Prodanović¹,

Nedić²,

Radanović

et al. 2019

VET GLASNIK

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Introduction. Neonatal calves are often deficient in iron. Accumulating evidence indicates that iron status is associated with disease pathologies including diarrhea. Our objective was to examine the association between iron status and gut function in neonatal calves with and without a history of calf diarrhea. Materials and Methods. Calves were divided into two groups based on their history of diarrhea; the first group were diarrheic calves (n=6) and the second group were nondiarrheic healthy calves (n=6). Blood samples (n=12) were collected at day 12 of age and erythrogram determination and measurements of serum iron and total iron binding capacity were performed. Hematological values were measured using an automatic analyzer, and biochemical properties were determined spectrophotometrically. Fecal samples were obtained from all calves and pH measured using semi quantitative test strips as well as being examined by bacterial cultivation for enterotoxigenic Escherichia coli, Salmonella spp. and Clostridium perfringens, by RT-PCR for the presence of bovine rotavirus, bovine coronavirus and bovine viral diarrhea virus, and by microscopy for the presence of Cryptosporidium parvum. Results and Conclusions. There were significant iron-related changes for most hematological indices in diarrheic calves; and iron (Fe) deficiency and microcytic, hypochromic anemia were diagnosed. The pH of the feces was significantly higher in diarrheic calves than in the non-diarrheic healthy group (P<0.01). All fecal samples were negative for the analyzed enteric pathogens. According to the results obtained, calves experiencing iron

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Occurrence of neonatal diarrhea in calves with iron-deficiency anemia

Prodanović¹,

Nedić²,

Radanović

et al. 2019

VET GLASNIK

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show abstract

“…Although the creep feed, oral paste, drinking water, and milk replacer could provide the certain amount of iron to the piglets, orally supplemented iron needs to be absorbed and its absorption rate depends on the iron status in the body, iron intake, and interaction with other trace minerals such as copper and zinc, other dietary factors such as phytate, and gut closure in newborn piglets [ 18 ]. Furthermore, it has been reported that oral supplementation of iron to piglets was not efficient due to low absorption rate caused by low gastric acid secretion, immature digestive tract reducing the absorption and weak digestive tract motility [ 10 , 22 ]. Thus, the iron supplementation via oral administration routes may require multiple of continuous administration of iron [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Additional Iron Injection to Suckling Pigs on Hematocrit Level during the Suckling Period

Albers

Pintens

Isensee

et al. 2022

Animals

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Two experiments were conducted to evaluate the effects of additional iron injection to suckling piglets on hematocrit level during the suckling period. In Experiment 1, a total of 24 piglets were allotted into 3 treatments within litter based on body weight and sex at d 1 of age. Treatments were: (1) Control: a 200 mg iron-dextran intramuscular injection only at d 0 of experiment (d 1 of age), (2) Iron100: intramuscular iron-dextran injections at d 0 (200 mg iron) and 15 (11 d before weaning) of experiment (100 mg iron), and (3) Iron200: intramuscular iron-dextran injections at d 0 (200 mg iron) and 15 of experiment (200 mg iron). In Experiment 2, a total of 20 piglets were allotted into 2 treatments within litter based on body weight and sex at d 1 to 2 of age. Treatments were: (1) Iron100b: 100 mg iron-dextran intramuscular injection at d 0 of experiment (d 1 to 2 of age), and (2) Iron200b: 200 mg iron-dextran intramuscular injection at d 0 of experiment. An additional 200 mg iron-dextran was injected to all piglets intramuscularly at d 14 of experiment (11 d before weaning). In Experiment 1, there was no difference in hematocrit levels among treatments at d 15 of experiment. Both iron treatments had greater hematocrit levels than the Control treatment at d 22 and 26 of experiment (p < 0.05). The Iron200 treatment had greater hematocrit level at d 26 of experiment (p < 0.05) and tended to have a greater increase of hematocrit levels in d 22 to 26 of experiment (p = 0.09) than the Iron100 treatment. In Experiment 2, the Iron200b treatment had greater hematocrit levels than the Iron100b treatment in d 14 and 25 (p < 0.05) of experiment. Hematocrit level changes tended to be greater in the Iron200b treatment in d 0 to 14 (p = 0.08) of experiment but lower in d 14 to 25 (p < 0.05) of experiment than the Iron100b treatment. The additional iron injection to suckling piglets increased hematocrit levels with greater values at weaning in the higher injection level whereas the increase was greater when the hematocrit level was low at the time of additional injection.

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Serum ferritin and stomach cancer risk among a japanese population

Akiba

Neriishi

Blot

et al. 1991

Cancer

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Using stored serum samples collected during from 1970 to 1972 and/or 1977 to 1979 from a fixed population in Hiroshima and Nagasaki, Japan, serum ferritin, transferrin, and ceruloplasmin levels were determined immunologically for persons in whom stomach (233 cases) or lung cancer (84 cases) subsequently developed as well as for their controls. An elevated stomach cancer risk was associated with low antecedent serum ferritin levels, with more than a threefold excess among those in the lowest compared with the highest ferritin quintile. The risk did not vary with the time between blood collection and stomach cancer onset, remaining high among those with low ferritin levels 5 or more years before cancer diagnosis. Achlorhydria, diagnosed in a sample of the population about 10 years before the 1970-to-1972 blood collection and up to 25 years before cancer, was an independent marker of stomach cancer risk. In combination, low serum ferritin and achlorhydria were associated with a tenfold increase in the subsequent risk. No effect of transferrin or ceruloplasmin, independent of ferritin, was observed in the gastric cancer risk, and the risk of lung cancer was not related to these three serum proteins. These prospective findings indicate that biologic markers of an increased risk of stomach cancer can be detected long before cancer onset.

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Gastric structure and function in iron-deficient piglets

Cited by 6 publications

References 10 publications

Occurrence of neonatal diarrhea in calves with iron-deficiency anemia

Occurrence of neonatal diarrhea in calves with iron-deficiency anemia

Effect of Additional Iron Injection to Suckling Pigs on Hematocrit Level during the Suckling Period

Serum ferritin and stomach cancer risk among a japanese population

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