Gastric stromal tumors Reappraisal of histogenesis

Mazur, Michael T.; Clark, Helen E.

doi:10.1097/00000478-198309000-00001

Cited by 862 publications

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“…They may arise from any of the layers of the intestinal wall and are classified as nonepithelial, mesenchymal neoplasms [2]. The most common type is the gastrointestinal stromal tumor (GIST), first described by Mazur and Clark in 1983 [3], which originates from the interstitial cells of Cajal. These cells have myogenic and neurogenic architecture and are found within the mesenteric plexus, submucosa, and muscularis propria of the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study

et al. 2012

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Background A submucosal tumor (SMT) of the stomach, which is an occasional finding during routine upper gastrointestinal endoscopy, may pose diagnostic and therapeutic challenges. Methods To assess whether endoscopic submucosal dissection (ESD) is a feasible approach to definitively cure SMTs, the authors performed a retrospective cohort study with two endoscopic italian centers.Results The study consisted of 20 patients with SMTs who underwent ESD. The patients underwent ESD and were followed up by endoscopy. We analyzed complete resection rate, frequency of complications, and survival. The overall rate of R0 resection was 90 % (18/20), with two endoscopic failures, one for a submucosal tumor and one for a neoplasm deeply infiltrating the proper muscle layer. The median procedure time was 119.1 min (range 40-240 min). The median size of the resected specimens was 29 mm (range 15-60 mm). Perforation occurred in 3 patients; all were treated conservatively. There were no cases of severe bleeding. Based on histopathological findings, 6 cases of ectopic pancreas, 1 of ectopic spleen, 3 of leiomyoma, and 10 of gastrointestinal stromal tumor (GIST) were diagnosed. Complete resection was obtained in all GIST cases. Among the 10 GIST cases treated by ESD, no death occurred: the 5-year disease-specific survival rate was 100 %. Conclusions The high success rate of 90 % and the low incidence of complications should indicate ESD is the correct diagnostic and definitive treatment in selected patients.

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Section: Introductionmentioning

confidence: 99%

Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study

et al. 2012

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“…However, in 1983, Mazur et al reported the presence of stomach-derived mesenchymal cells, from a gastric stromal tumor (20). Since then, similar reports have also been considered to represent GISTs, and current diagnostic criteria have been established that utilize immunostaining with the c-kit.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemia Associated with a Gastrointestinal Stromal Tumor Producing High-molecular-weight Insulin Growth Factor II: A Case Report and Literature Review

et al. 2016

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A 61-year-old woman with multiple metastatic and unresectable gastrointestinal stromal tumors (GISTs) was referred for investigation of refractory hypoglycemia that developed four months before this hospitalization. On admission, her fasting plasma glucose was 38 mg/dL despite 10% glucose infusion. Investigations revealed that her serum C-peptide, insulin and growth hormone levels were suppressed, and big insulin-like growth factor II was observed. She was diagnosed with non-islet cell tumor hypoglycemia, which resolved after glucocorticoid treatment. Clinicians should thus be vigilant to identify hypoglycemia in patients with large metastatic GISTs because glucocorticoid therapy is useful even if the GIST is inoperable.

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“…6 If we go through the literature there are cases reported on perforation of jejunal GIST. 7 Skipworth, J.R .…”

Section: Discussionmentioning

confidence: 99%

Perforation of gastric gastrointestinal stromal tumor: A rare phenomenon & review of literature

Agrawal¹,

Wasnik²,

Yede³

et al. 2014

Int J of Biomed & Adv Res

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Gastric stromal tumors Reappraisal of histogenesis

Cited by 862 publications

References 0 publications

Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study

Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study

Hypoglycemia Associated with a Gastrointestinal Stromal Tumor Producing High-molecular-weight Insulin Growth Factor II: A Case Report and Literature Review

Perforation of gastric gastrointestinal stromal tumor: A rare phenomenon & review of literature

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