Gastric secretion, mucosal erosions and porto-systemic gastrin gradients as influenced by different degrees of stress in the rat

Wolf, U.; Schwille, P. O.; Engelhardt, W

doi:10.1007/bf01851620

Cited by 6 publications

(10 citation statements)

References 19 publications

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“…Details of these techniques have been described, as well as the blood sampling and storage procedures for serum and plasma [33].…”

Section: Experimental Conditionsmentioning

confidence: 99%

“…Ulcer index and severity of lesions were assessed as reported previously [33]. Acid secretion (mM/kg/h) and pepsin secretion (kU/kg/h) were calculated in the usual manner (concentration × secretory volume per time period), the MBF analogously (ml/kg/min).…”

Section: Analysesmentioning

confidence: 99%

“…Preparation of the animals for the experimental period (gastric fistula, i.p. polyethylene catheter for delivery of the MBF-marker 14C-aminopyrine and glucagon) was as described previously [33].…”

Section: Animals and Preparationsmentioning

confidence: 99%

“…At present, the stress-mediated decrease in mucosal blood flow (MBF) is con- sidered a critical variable [14]. In immobilization stress of the rat, a common neurally mediated kind of stress for induction of ulcers, MBF, and also acid secretion are decreased [10,11,15,24,33], while A-cell glucagon in plasma is elevated [24,25,26]. In a number of species, exogenous glucagon inhibits acid secretion [9].…”

Section: Introductionmentioning

confidence: 99%

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Influence of exogenous glucagon on gastric acid secretion, mucosal blood flow, and stress ulcers in the rat: Dose-response results under non-stress conditions and immobilization stress

et al. 1983

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In non-stressed rats and rats stressed by immobilization, gastric secretion (acid, pepsin), mucosal blood flow (MBF), stress ulcers as well as glucose, insulin, and glucagon in blood were studied during 8 h, with and without additional infusion of exogenous glucagon (0.2, 1.4, 9.8 micrograms/kg/h). Metabolic clearance of glucagon and the disappearance half-time of exogenous glucagon from blood do not differ during zero stress and stress, a fact that favors the assumption of hypersecretion of glucagon as the cause of stress hyperglucagonemia. During stress alone acid secretion (volume, acidity) and MBF are lower than during zero stress; pepsin remains unchanged. Under zero stress condition additionally administered glucagon inhibits pepsin and MBF, but not acid secretion, in a dose-dependent manner. The ulcer index increased without changing the severity of ulcers. During stress the intermediate and highest glucagon doses stimulate MBF and pepsin secretion, other variables remaining unchanged. It is concluded that glucagon effects on functions of the gastric mucosa in the rat vary fundamentally, depending upon the environmental conditions.

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“…Details of these techniques have been described, as well as the blood sampling and storage procedures for serum and plasma [33].…”

Section: Experimental Conditionsmentioning

confidence: 99%

Section: Analysesmentioning

confidence: 99%

Section: Animals and Preparationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of exogenous glucagon on gastric acid secretion, mucosal blood flow, and stress ulcers in the rat: Dose-response results under non-stress conditions and immobilization stress

et al. 1983

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“…The techniques practiced have been described in detail elsewhere [Wolf et al, 1981]. In brief: 24-hour fasted rats were placed individually in metabolic cages and received an intraperitoneal infusion of 0.15 M NaCl (4 ml/kg/h) containing 0.3 pCi/kg/h of the mucosal blood flow (MBF) marker l4C-aminopyrine (bolus into tail vein 1.3 Ci/kg).…”

Section: Experimental Conditionsmentioning

confidence: 99%

Basal Gastric Secretion, Mucosal Blood Flow and Associated Fasting Blood Hormones in the Rat

Hanisch¹,

Po²

1982

Eur Surg Res

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After vagotomy (truncal, highly selective, superselective) in rats, basal gastric secretion, gastric mucosal blood flow, associated fasting blood glucose and a variety of hormones were measured. All forms of vagotomy reduce acid (volume, acidity, output), but highly selective and superselective – though not truncal – procedures stimulate basal pepsin secretion, whereas mucosal blood flow roughly parallels acid production. Spontaneous gastric mucosal lesions increase after highly selective vagotomy. Both highly selective and superselective – but not truncal – vagotomy tend to increase plasma glucose and somatostatin, while only the former reduces insulin and glucagon. Common to all vagotomies is the development of virtually undetectable calcitonin (<25 pg/ml) and of hypergastrinemia. It is concluded that in the rat with draining gastric fistula in response to vagotomy there are moderate differences in regard to gastric mucosal ulcer index, gastric secretion, glucose, glucose-regulating hormones, while lowered calcitonin may be a general feature of low vagal tone.

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Gastric acid secretion and lesion formation in rats under water-immersion stress

Hayase

Takeuchi

1986

Digest Dis Sci

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In attempts to investigate the roles of acid in the pathogenesis of stress-induced gastric lesions, gastric acid secretion was studied in pylorus-ligated and lumen-perfused rats under restraint alone (R) or restraint with additional water immersion (WI). Gastric mucosal blood flow (GMBF) was measured with the aminopyrine clearance method in acute fistula rats. Acid secretion in pylorus-ligated rats significantly decreased under R or WI of either 3.5 or 7 hr stress. In the lumen-perfused or acute-fistula rats, exposure of rats to stress for 7 hr produced a similar decrease; however, in the WI group, there was a significant increase of acid secretion for 3-4 hr during stress, but not exceeding the prestress level. Only in the WI group did GMBF exhibit similar increases to those of acid secretory activity, and these increases were significantly inhibited by intraperitoneal administration of atropine (1 mg/kg) or cimetidine (60 mg/kg). Gastric lesions developed in both groups at 3.5 hr and became extensively severe at 7 hr only in the WI group. Cimetidine failed to influence the formation of lesions at 3.5 hr but significantly inhibited the later outgrowth of lesions at 7 hr, while atropine or pylorus ligation all but completely prevented lesions induced by either 3.5- or 7-hr WI stress. These results indicate that exposure of rats to stress (R or WI) generally decreased acid secretory activity, but there was a rise in acid secretion toward normal levels during WI stress, which may play an important role in the aggravating process of stress-induced gastric lesions.

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Gastric secretion, mucosal erosions and porto-systemic gastrin gradients as influenced by different degrees of stress in the rat

Cited by 6 publications

References 19 publications

Influence of exogenous glucagon on gastric acid secretion, mucosal blood flow, and stress ulcers in the rat: Dose-response results under non-stress conditions and immobilization stress

Influence of exogenous glucagon on gastric acid secretion, mucosal blood flow, and stress ulcers in the rat: Dose-response results under non-stress conditions and immobilization stress

Basal Gastric Secretion, Mucosal Blood Flow and Associated Fasting Blood Hormones in the Rat

Gastric acid secretion and lesion formation in rats under water-immersion stress

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