Gastric Secretion in Graves's Disease.

Moll, H; Scott, Ryan

doi:10.1016/s0140-6736(00)73059-5

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Contrary to previous reports (8,10,13), our results indicate no relationship between the incidence of achlorhydria and the duration of the disease, height of the metabolism or age of the patient.…”

Section: Methodscontrasting

confidence: 99%

“…This is a definitely higher figure than most investigators have reported (5,7,8,10) and is more nearly comparable to that found by Herzfeld (6) and Moore (11).…”

Section: Methodssupporting

confidence: 86%

“…There is a high incidence of achlorhydria and hypoacidity irrespective of whether the hyperthyroidism is associated with exophthalmic goiter or with adenomatous goiter with hyperfunction. This latter finding is of particular value as previous investigators have reported that achlorhydria is either rare (5) or does not occur in adenomatous goiter with hyperfunction (8).…”

Section: Methodsmentioning

confidence: 53%

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A Study of the Gastric Secretion in Hyperthyroidism Before and After Operation

Berryhill¹,

Williams²

1932

J. Clin. Invest.

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Gastric symptoms have long been associated with hyperthyroidism. The reports of studies attempting to correlate these symptoms with disturbances in gastric secretions are not uniform. Several investigators (I, 2) report an increase in the hydrochloric acid and total volume of secretion. One (3) contends there is no characteristic secretion in exophthalmic goiter. A greater number (4-16) report a diminution or absence of hydrochloric acid in hyperthyroidism and in the feeding of thyroid extracts to animals. Excellent reviews of the subject have appeared in recent papers by Moll and Flint (9), Brown (10), and Lerman and Means (13). With the development of a more accurate method for determining the degree of gastric acidity by histamine stimulation it seemed desirable to restudy the problem. Accordingly, a survey was begun eighteen months ago to determine the behavior of gastric secretion in hyperthyroidism before and after operation. Since the beginning of this work, Lerman and Means (13) have reported a study of gastric secretion in exophthalmic goiter before treatment using a similar method. METHODThe present generally accepted technique of gastric analysis was employed in this study. A fasting specimen was withdrawn, followed by the ingestion of 50 cc. of 7 per cent alcohol. Specimens were removed at twenty and forty minute intervals. If the last specimen contained no hydrochloric acid, histamine (ergotamine acid phosphate) 0.1 mgm. per ten kilograms was given subcutaneously and specimens were withdrawn at twenty and forty minute intervals. The volume, free hydrochloric acid and total acidity of each specimen were determined. T6pfer's reagent and phenolphthalein respectively were used as indicators and the results expressed as the number of cc. of N/1O NaOH necessary to neutralize 100 cc. of gastric juice.Two analyses were done on each patient before preoperative iodine therapy was begun, a third the day before operation, and a fourth the day of discharge. The patients were followed by subsequent analyses at intervals of one to two months. We have arbitrarily classified the results upon the basis of the highest acid content obtained after the stimulation by alcohol and histamine: (1) Normals, those patients in whom repeated analyses showed free hydrochloric 753

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Section: Methodscontrasting

confidence: 99%

“…This is a definitely higher figure than most investigators have reported (5,7,8,10) and is more nearly comparable to that found by Herzfeld (6) and Moore (11).…”

Section: Methodssupporting

confidence: 86%

Section: Methodsmentioning

confidence: 53%

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A Study of the Gastric Secretion in Hyperthyroidism Before and After Operation

Berryhill¹,

Williams²

1932

J. Clin. Invest.

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“…Lockwood (2) studied the gastric contents of 24 patients with hyperthyroidism who had digestive complaints and found 10 or 41.6 per cent showed no free hydrochloric acid, 3 low acid and 11 normal acid. Similarly Moll and Scott (3), in a series of 34 patients with definite exophthalmic goitre, found 19 (56 per cent) with achlorhydria, 10 with hypochlorhydria, 4 with normal acid and 1 with high acid. Herzfeld (4) obtained the following results in 22 cases: achlorhydria and hypoacidity 15, normal acidity 4, and increased acidity 3.…”

mentioning

confidence: 83%

The Gastric Secretion in Exophthalmic Goitre and Myxoedema

Jacob

Means²

1932

J. Clin. Invest.

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The depressive influence of the sympathetic nerves on gastric acidity

Moll

Flint

1928

Journal of British Surgery

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ASSISTAST S U H O X O S I N TIW GEXERAI, IXFIRMAKY, I.EEDS.TIIIS study has been undertaken in order to obtain further information about the inhibitory influence, if any, of the sympathetic nerves on gastric acidity.Evidence in favour of the depressive influcnces reaching the stomach by the splaiichriic nerves will be deduced from :-I . Uitzicul 00seri!ations : (1) Gastric analyses in cases of hyperthyroidism ; (2) Thc effect of thyroid feeding on gastric secretion ; (3) Changes produced by adrenalin and nicotine administration ; (4) Depressive action of emotions on acid secrction.11. E: iperittieiitul Obsewatioris : Observations on HC1 secretion after bilateral section of the splanclinic nerves in the dog.

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Gastric Secretion in Graves's Disease.

Cited by 8 publications

References 6 publications

A Study of the Gastric Secretion in Hyperthyroidism Before and After Operation

A Study of the Gastric Secretion in Hyperthyroidism Before and After Operation

The Gastric Secretion in Exophthalmic Goitre and Myxoedema

The depressive influence of the sympathetic nerves on gastric acidity

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