Gastric Sarcoidosis and Review of the Literature

Afshar, Kamyar; BoydKing, Ayana; Sharma, Om P.; Shigemitsu, Hidenobu

doi:10.1016/s0027-9684(15)30577-0

Cited by 43 publications

(46 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sarcoidosis is an infl ammatory condition characterized by development of chronic, systemic, non-caseating granuloma [4][5][6][7][8][9][10]. With the exact cause still unknown, the disease affects mostly the respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Gastritis Associated with Sarcoidosis: Case Report

Ortac¹

2017

Arch Clin Gastroenterol

View full text Add to dashboard Cite

Granulomatous gastritis is a condition which may occur in association with Crohn's disease, sarcoidosis, Wegener's granulomatosis, tuberculosis, foreign body reaction or certain drugs including cocaine. Here, we report a diagnosis of granulomatous gastritis in a sarcoidosis patient who presented with non-specifi c dyspeptic complaints. Case Report Granulomatous Gastritis Case ReportThe 41-year-old female patient, who had a prior diagnosis of sarcoidosis and is currently in remission, presented to our clinic with abdominal bloating, indigestion and heartburn.Her upper gastrointestinal system endoscopy demonstrated normal esophagus and duodenal mucosa, but hyperemic and edematous gastric mucosa at the antrum and corpus. Gastric biopsies from the antrum and corpus were taken. The result of the biopsy was reported as H. pylori-positive chronic gastritis in the antrum and granulomatous gastritis. Granulomatous gastritis without caseifi cation consisting of epithelioid histiocytes and multinuclear giant cells were also observed with the biopsies (Figures 1-4). The patient was therefore questioned again and described no evidence suggestive of sarcoidosis or any complaints other than dyspeptic ones. With completely normal results from pulmonary x-ray, abdominal ultrasonography and laboratory investigations, treatment for sarcoidosis was not deemed necessary. The patient was given proton pump inhibitor therapy together with a 14-day clarithromycin, bismuth subsalicylate and tetracycline therapy for helicobacter pylori eradication. Patient's follow-up examination demonstrated that her complaints disappeared following eradication. Cortisone therapy was therefore not commenced.

show abstract

Section: Discussionmentioning

confidence: 99%

Granulomatous Gastritis Associated with Sarcoidosis: Case Report

Ortac¹

2017

Arch Clin Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Clinically recognizable GI involvement is uncommon occuring in less than %1 of the patients, although the incidence of subclinical disease may be much higher [1,12,13]. On the other hand, granulomas in the gastric biopsy specimens are extremely rare and are mostly associated with Crohn's disease, tuberculosis, histoplasmosis, isolated granulomatous gastritis, vasculitis, and lymphoma [7,14,15,16]. Second the symptoms were exceptional.…”

Section: Discussionmentioning

confidence: 99%

“…Stomach is the most common site but these cases are often clinically silent [5,6]. In literature, there are only few cases of symptomatic gastric sarcoidosis with documented histopathological evidence of noncaseiting granulomas [7]. Diagnosis of isolated gastric sarcoidosis constitutes difficulties for the clinician due to its atypical clinical profile and subclinical occurence.…”

Section: Introductionmentioning

confidence: 99%

Gastric Sarcoidosis: An Atypical Presentation of a Rare Disease

Yanardağ¹,

Tetikkurt²,

Bilir³

et al. 2017

AJMCR

View full text Add to dashboard Cite

Sarcoidosis is a multisystemic granulomatous disease characterised by the histologic evidence of granulomas in various organs. Clinically discernible gastric sarcoidosis is extremely rare, reported in less than 1% of the patients. We present a case of gastric sarcoidosis with atypicial manifestations and without current pulmonary disease. The patient was admitted for gastric fullness, anorexia, and weight loss. She had a history of migraine and nodular goiter. Family history revealed bladder carcinoma in the mother and gastric carcinoma in the uncle. Initial laboratory findings and chest x-ray were normal. Biopsies from the gastric mucosa revealed noncaseating granulomas with focal multinucleate giant cells. Six months after the patient was admitted for dry cough and fatigue. Chest x-ray and CT revealed diffuse nodules in the upper and middle lung zones. Transbronchial biopsy demonstrated noncaseiting granulomas compatible with sarcoidosis. The patient was started on mehtylprednisolone and had a significant improvement in her symptoms. This case is an unique paradigm for the exceptional presentation of sarcoidosis. Isolated extrapulmonary organ involvement without simultaneous lung disease may be the initial manifestation of sarcoidosis. Meticulous follow-up for sarcoidosis is required for patients presenting with atypical symptoms and noncaseiting granulomas in any extrapulmonary organ.

show abstract

“…The stomach, especially the antrum, is the organ most often involved. In 2010, Afshar et al [13] , through a MEDLINE search, reported only 26 cases of symptomatic gastric sarcoidosis with well-documented histological evidence of noncaseating granulomas. The most common symptoms of gastric sarcoidosis are abdominal pain, hematemesis, nausea, vomiting, and weight loss [3,5,13] .…”

Section: Sarcoidosismentioning

confidence: 99%

“…In 2010, Afshar et al [13] , through a MEDLINE search, reported only 26 cases of symptomatic gastric sarcoidosis with well-documented histological evidence of noncaseating granulomas. The most common symptoms of gastric sarcoidosis are abdominal pain, hematemesis, nausea, vomiting, and weight loss [3,5,13] . Endoscopy may reveal gastritis, curvature deformation, and ulcers of benign or malignant appearance [3,13] .…”

Section: Sarcoidosismentioning

confidence: 99%

Multisystemic Sarcoidosis with Early Gastrointestinal Symptoms

Mota

Ferreira

Oliveira

et al. 2016

GE Port J Gastroenterol

View full text Add to dashboard Cite

Sarcoidosis involving the digestive tract is very rare and requires a strict differential diagnosis with other systemic granulomatous diseases. We present a case of multisystemic granulomatosis involving the stomach and colon, causing initial digestive symptoms. Pulmonary nodules, pleural effusion, ascites, hepatomegaly, splenomegaly, and mesenteric as well as retroperitoneal and axillary lymphadenopathy were subsequently identified. The reticulo-endothelial expression, the hypercalcemia and, above all, a rapid and complete resolution after corticosteroids supported the hypothesis of sarcoidosis involving the digestive tract. A brief review of digestive tract involvement in sarcoidosis and of the distinctive features of sarcoidosis with gastrointestinal involvement and Crohn's disease with a rare form of pleuro-pulmonary involvement is presented.

show abstract

Gastric Sarcoidosis and Review of the Literature

Cited by 43 publications

References 20 publications

Granulomatous Gastritis Associated with Sarcoidosis: Case Report

Granulomatous Gastritis Associated with Sarcoidosis: Case Report

Gastric Sarcoidosis: An Atypical Presentation of a Rare Disease

Multisystemic Sarcoidosis with Early Gastrointestinal Symptoms

Contact Info

Product

Resources

About